U.S. Route 45 is a major north-south United States highway and a border-to-border route, from Lake Superior to the Gulf of Mexico. A sign at the highway's northern terminus notes the total distance as 1,297 miles (2,087 km).
U.S. Route 45E (US 45E) is a 61.23-mile-long (98.54 km) state highway in West Tennessee, connecting Jackson with South Fulton via Milan and Martin. For the majority of its length, it runs concurrently with unsigned State Route 43 (SR 43) for most of that highway’s length except for short segments at Martin and South Fulton, where it is cosigned with SR 216 and SR 215, respectively.
U.S. Route 45W is a 62.33-mile-long (100.31 km) United States Numbered Highway in West Tennessee, connecting Jackson with South Fulton via Humboldt, Trenton, Rutherford, and Union City. For the majority of its length, it runs concurrently with unsigned State Route 5.
State Route 22 is a 172.8-mile long (278.1 km) south-to-north state highway in the western part of Tennessee, United States. It begins at the Mississippi state line in McNairy County, where the roadway continues as Mississippi Highway 2. It ends at the Kentucky state line in Lake County, when it crosses into the Kentucky Bend, a detached portion of Fulton County, Kentucky. The monument for the 1862 Battle of Island Number Ten in the American Civil War is located on SR 22, about 3 mi (4.8 km) north of Tiptonville.
State Route 43 is a south to north highway in Tennessee that is 56.79 miles (91.39 km) long. It begins in Madison County and ends in Obion County. State Route 43 is little-known by the general public by this designation as it is overlain by U.S. Route 45E for most of its length; the "43" designation is seen largely on mileposts. Two short sections of this route at Martin and South Fulton is fully signed. SR 43 from its southern terminus to Milan is designated as a Strategic Highway Network connector route servicing the Milan Arsenal.
State Route 5 is a 120-mile-long (190 km) north–south state highway in the western part of the U.S. state of Tennessee. Except for the section northwest of Union City, it is entirely concurrent with U.S. Route 45 and US 45W.
State Route 20 (SR 20) is a 143.04-mile (230.20 km) long east–west primary state highway that begins in Dyersburg and ending near Summertown. SR 20 is unsigned and concurrent with U.S. Route 412 (US 412) for its entire length, except for a short section between Hohenwald and Summertown. Along its route, SR 20 traverses parts of both Middle Tennessee and West Tennessee.
U.S. Route 70 Alternate is a 61.7-mile-long (99.3 km) alternate route to US 70 between Brownsville, and Huntingdon in West Tennessee. Signage along this route, and on most maps, show it as US 70A and not US 70 Alternate.
State Route 76 (SR 76) is a state highway in Tennessee, traversing the state in a northeast-southwest axis from east of Memphis to north of Nashville. SR 76 is unique in that it actually changes its cardinal directions in Clarksville at the junction with US 41A and US 41A Bypass.
In Tennessee, U.S. Route 412 stretches for 181.93 miles (292.79 km) through the farmland of West Tennessee and the hills of Middle Tennessee, starting at the Missouri state line near Dyersburg and running to an interchange between I-65 and SR 99 in Columbia.
U.S. Route 45 (US 45) in Tennessee extends from the Mississippi state line to the Kentucky state line in West Tennessee, passing through the cities of Selmer, Henderson, Jackson, and South Fulton. Between Three Way and South Fulton, the highway is split into US 45W and US 45E.
State Route 54 is a west–east rural highway in West Tennessee, which runs from Covington to just north of Paris.
State Route 215 (SR 215) is an unsigned, east–west, state highway entirely within the city limits of South Fulton, Tennessee, although the direction is more northwest to southeast as it curves around the southwest part of the city. It is better known as US 45E and is briefly US 51 near the Kentucky state line. The route serves as a bypass for South Fulton. The northwestern portion is a four-lane divided highway and the southeastern portion is a four lane undivided highway with a center left turn lane.
State Route 77 (SR 77), is an east–west state highway in the U.S. state of Tennessee. The 84.86-mile-long (136.57 km) route traverses the flat farmland of West Tennessee.
State Route 105 is a 44.34-mile-long (71.36 km) east–west state highway in West Tennessee. It traverses mainly rural areas and farmland.
State Route 104 is a 114.43-mile-long east–west state highway in West Tennessee.
State Route 152 is a 36.88-mile-long (59.35 km) east-west state highway traversing the flat farmland of West Tennessee.
State Route 216 is a 17.7-mile-long (28.5 km) east–west state highway in West Tennessee, connecting Rives with Martin.
State Route 367, also known as College Street, is a short 4.80-mile-long (7.72 km) north-south state highway located entirely in the city of Trenton, Tennessee.
State Route 366 is the unsigned designation for the 5.48-mile-long (8.82 km) northern beltway around the city of Humboldt in Gibson County, Tennessee. Throughout its length, the highway is signed as U.S. Route 45W, US 70A Bypass, and US 79 Bypass.
US 45W in Trenton 
US 45 / US 70 in Jackson 
