Ternatin heptapeptide

Ternatin heptapeptide
Identifiers
CAS Number	148619-41-4 ;
3D model (JSmol)	Interactive image ; (natural): Interactive image ;
ChemSpider	167002 ; (natural): 9882259 ;
PubChem CID	192406 ; (natural): 11707536 ;
CompTox Dashboard (EPA)	DTXSID20933442 ;
	InChI InChI=1S/C37H67N7O8/c1-16-22(8)28-37(52)43(14)25(11)35(50)44(15)27(18-20(4)5)32(47)38-26(17-19(2)3)36(51)42(13)24(10)34(49)41(12)23(9)31(46)40-29(33(48)39-28)30(45)21(6)7/h19-30,45H,16-18H2,1-15H3,(H,38,47)(H,39,48)(H,40,46) Key: ZMFVAIFXJWEOMH-UHFFFAOYSA-N; (natural):InChI=1S/C37H67N7O8/c1-16-22(8)28-37(52)43(14)25(11)35(50)44(15)27(18-20(4)5)32(47)38-26(17-19(2)3)36(51)42(13)24(10)34(49)41(12)23(9)31(46)40-29(33(48)39-28)30(45)21(6)7/h19-30,45H,16-18H2,1-15H3,(H,38,47)(H,39,48)(H,40,46)/t22-,23+,24-,25-,26-,27-,28+,29+,30+/m0/s1 Key: ZMFVAIFXJWEOMH-PTPSPKLBSA-N;
	SMILES CCC(C)C1C(=O)N(C(C(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)NC(C(=O)N1)C(C(C)C)O)C)C)C)C)CC(C)C)CC(C)C)C)C)C; (natural):CC[C@H](C)[C@H]1NC(=O)[C@@H]([C@H](O)C(C)C)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C)N(C)C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C)N(C)C1=O;
Properties
Chemical formula	C37H67N7O8
Molar mass	737.984 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Last updated July 19, 2025

Ternatin is a mushroom heptapeptide that suppresses hyperglycemia in vivo.^[2]

References

↑ "Human Metabolome Database: Showing metabocard for Ternatin (HMDB0040991)". hmdb.ca.
↑ Kobayashi, M.; Kawashima, H.; Takemori, K.; Ito, H.; Murai, A.; Masuda, S.; Yamada, K.; Uemura, D.; Horio, F. (2012). "Ternatin, a cyclic peptide isolated from mushroom, and its derivative suppress hyperglycemia and hepatic fatty acid synthesis in spontaneously diabetic KK-A(y) mice". Biochemical and Biophysical Research Communications . 427 (2): 299–304. doi:10.1016/j.bbrc.2012.09.045. PMID 23000156.

Shimokawa K, Iwase Y, Miwa R, Yamada K, Uemura D. Whole structure-activity relationships of the fat-accumulation inhibitor (-)-ternatin: recognition of the importance of each amino acid residue. J Med Chem. 2008 Oct 9;51(19):5912-4. doi: 10.1021/jm800741n. Epub 2008 Sep 18. PMID 18798610.

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[1] "Human Metabolome Database: Showing metabocard for Ternatin (HMDB0040991)". hmdb.ca.

[2] Kobayashi, M.; Kawashima, H.; Takemori, K.; Ito, H.; Murai, A.; Masuda, S.; Yamada, K.; Uemura, D.; Horio, F. (2012). "Ternatin, a cyclic peptide isolated from mushroom, and its derivative suppress hyperglycemia and hepatic fatty acid synthesis in spontaneously diabetic KK-A(y) mice". Biochemical and Biophysical Research Communications . 427 (2): 299–304. doi:10.1016/j.bbrc.2012.09.045. PMID 23000156.

[1]

[2]

Identifiers

CAS Number	148619-41-4 ^N^[1]
3D model (JSmol)	Interactive image (natural): Interactive image
ChemSpider	167002 (natural): 9882259
PubChem CID	192406 (natural): 11707536
CompTox Dashboard (EPA)	DTXSID20933442
InChI InChI=1S/C37H67N7O8/c1-16-22(8)28-37(52)43(14)25(11)35(50)44(15)27(18-20(4)5)32(47)38-26(17-19(2)3)36(51)42(13)24(10)34(49)41(12)23(9)31(46)40-29(33(48)39-28)30(45)21(6)7/h19-30,45H,16-18H2,1-15H3,(H,38,47)(H,39,48)(H,40,46) Key: ZMFVAIFXJWEOMH-UHFFFAOYSA-N (natural):InChI=1S/C37H67N7O8/c1-16-22(8)28-37(52)43(14)25(11)35(50)44(15)27(18-20(4)5)32(47)38-26(17-19(2)3)36(51)42(13)24(10)34(49)41(12)23(9)31(46)40-29(33(48)39-28)30(45)21(6)7/h19-30,45H,16-18H2,1-15H3,(H,38,47)(H,39,48)(H,40,46)/t22-,23+,24-,25-,26-,27-,28+,29+,30+/m0/s1 Key: ZMFVAIFXJWEOMH-PTPSPKLBSA-N
SMILES CCC(C)C1C(=O)N(C(C(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)NC(C(=O)N1)C(C(C)C)O)C)C)C)C)CC(C)C)CC(C)C)C)C)C (natural):CC[C@H](C)[C@H]1NC(=O)[C@@H]([C@H](O)C(C)C)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C)N(C)C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C)N(C)C1=O
Properties
Chemical formula	C₃₇H₆₇N₇O₈
Molar mass	737.984 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references