Plot
Kate and Meg are lifelong friends and roommates in Seattle experiencing stressful times. Kate is a high school English teacher who is being pressured by Principal Moss to resign, while Meg is a struggling cosmetics saleswoman. After a night of drinking, Meg suggests they go on vacation together to escape their stressful lives. Kate is reluctant, but ultimately acquiesces as Meg had already booked non-refundable tickets to Fort Lauderdale using Kate's frequent flyer miles.
On the plane, Kate and Meg are seated next to Ryan, a handsome firefighter on his way to a wedding. Both women are immediately attracted to him and begin to shamelessly flirt. A few hours into the flight, the plane is diverted to St. Louis due to a hurricane warning. The women are taken to the local Sheraton and run into Ryan, who invites them to drinks at the hotel club. Before going to bed, Kate tells Meg that she will fight her for Ryan's affections.
When it is learned the hurricane will move away from Florida, Ryan manages to get a ride from Craig, a jewelry salesman who had taken a liking to Meg but had been continually rebuffed by her, and the women ask to tag along. Kate shows embarrassing childhood photos of Meg to the men for their amusement so, in retaliation, Meg locks Kate in a gas station bathroom, forcing her to escape through a high window, getting covered in feces.
Back in the car, Kate fakes an injury to get a massage from Ryan, prompting Meg to place sleeping pills into a bottle of wine to give to her. When she declines to drink, Craig, who is driving, takes it instead, much to Meg's horror. After a few hours, Craig eventually passes out and crashes the car, forcing the four to spend the night at a motel.
When Kate sees the pills in the bottle, she asks for a hotel room for herself. Meg says that she can have Ryan, but Kate proclaims she never wanted him and merely did not want Meg to have him. Meg decides to go to a local bar where Craig joins her. When he fails to impress her, he suggests she be open to the qualities of other men.
Back at the hotel, Ryan makes a pass at Kate, who gives in and has rigorous sex with him. In the morning at breakfast, Meg tells Kate they should not jeopardize their friendship over a man, but when Meg lets slip that Ryan has a misshaped penis, she realizes Meg had sex with Ryan as well and they get into a physical fight, making a mess of the motel lobby in the process. Their fight ends when the motel manager calls the police on them.
Craig reveals to the police that Ryan had taken his car to reach the wedding on time. When he looks up Ryan's Google Plus profile, he sees that Ryan is the one getting married, revealing this to the women. Appalled, they beg to be released to stop the wedding, and are let go after paying for the damage to the lobby.
The two women arrive at the hotel in Fort Lauderdale where the wedding is taking place, but it is too late to stop it. They confront Ryan, who calls them out on throwing themselves at him. The women still insist it was wrong for him to sleep with both of them the night before his wedding and not tell them he was the one being married. Ryan admits he had been with his now-wife Genevieve since freshman year of college and has not been able to get with anyone else.
When the women meet Genevieve, they see that she is possessive, and choose not to tell her about his infidelity, seeing that Ryan will suffer from his miserable marriage. With a few hours before their flight back to Seattle, Meg tracks down Craig at his jewelry shop to apologize for brushing him off, kissing him before she leaves. At the airport, Meg tells Kate that they should not live together anymore, to which Kate tearfully agrees, as they have been too dependent on each other.
Kate returns to her job with renewed vigor, and requests that Principal Moss allow her students to indulge in their creativity more instead of just following the standard curriculum. Moss reveals to Kate that he had no intention of firing her; he actually wants to offer her the assistant volleyball coach position.
Meg starts taking classes and is in a long-distance relationship with Craig. Meanwhile, she has moved into an apartment only a few doors down from Kate so they can still be close.
