Thomas Martin (pathologist)

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Thomas John Martin
AO FRACP FRCPA FAA FRS [1]
Born
Thomas John "Jack" Martin

(1937-01-24) January 24, 1937 (age 88)
Education University of Melbourne [2] [3]
Degrees:
  • Bachelor of Medicine (MB) (1960) [2]
  • Bachelor of Surgery (BS) (1960) [2]
  • Doctor of Medicine (MD) (1969) [2]
  • Doctor of Science (DSc) (1979) [2]
Alma materUniversity of Melbourne
Known forDiscovery of parathyroid hormone-related protein (PTHrP)
Scientific career
Fields
Institutions

Thomas John "Jack" Martin is an Australian pathologist, emeritus professor of medicine, physician and academic at University of Melbourne, [2] [3] and researcher who, in 1987, by leading a former team of researchers at the same university, discovered a proteinaceous hormone called parathyroid hormone-related protein (PTHrP). [4] [5] In September 2005, further research was conducted by the team of Dengshun Miao [6] and David Goltzman at the Calcium Research Laboratory and Department of Medicine, Royal Victoria Hospital of the McGill University Health Centre, and others. [6]

Contents

Martin is a member of Natalie A. Sims' laboratory [7] at Saint Vincent's Institute of Medical Research. [8] He works in the institute's Division of Medicine, Dentistry and Health Sciences, and his primary interest is cell biology of bones. [9]

Research career

Martin was the director of St Vincent's Institute from 1988 to 2002. [10] In September 2005, Martin found that PTHrP produced by osteoblasts is a physiological regulator of bone formation. [11]

In July 2022, Martin and his team at Natalie A. Sims' lab, after much research on mice, found that deletion of the gene that codes for a receptor protein called granulocyte colony-stimulating factor receptor (G-CSF) increases physiological dysfunction of cortical bones of mice having hyperactivated STAT3 proteins in their bone cells. [12] Cortical bone maturation depends on SOCS3-mediated suppression of interleukin-6 cytokine-induced STAT3 phosphorylation in bone cells, which form the cellular network embedded in bone matrix. They concluded that G-CSFR signaling could indirectly limit bone resorption and angiogenesis, and thereby has a major role in replacing condensed trabecular bone with lamellar bone during cortical bone formation. [12]

Awards and honours

YearAward
1969 Fellow of the Royal Australasian College of Physicians (FRACP) [2]
1971Selwyn Smith Prize for medical research [2]
1974Eric Susman Prize received from the Royal Australasian College of Physicians [2]
1990Lemberg Medal received from the Australian Biochemical Society [2]
1992
  • Honorary Doctor of Medicine (MD(Hon)) received from the University of Sheffield [2]
  • Dale Medal received from the British Society for Endocrinology [2]

References

  1. ↑ "Prof T.J. (Jack) Martin". Saint Vincent's Institute. Archived from the original on October 30, 2022. Retrieved October 30, 2022.
  2. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 Centre for Transformative Innovation, Swinburne University of Technology. "Martin, Thomas John (Jack)". Encyclopedia of Australian Science and Innovation . Archived from the original on January 1, 2023. Retrieved October 30, 2022.
  3. 1 2 Fioritti, Nathan (November 22, 2016). "Professor Emeritus Thomas John Martin AO". Faculty of Medicine, Dentistry and Health Sciences. Archived from the original on October 29, 2022. Retrieved October 30, 2022.
  4. ↑ Martin TJ, Moseley JM, Gillespie MT (1991). "Parathyroid hormone-related protein: biochemistry and molecular biology". Critical Reviews in Biochemistry and Molecular Biology. 26 (3–4): 377–395. doi:10.3109/10409239109114073. PMID   1935171.
  5. ↑ USpatent 5460978A,Martin TJ, Moseley JM, Kemp BE, Wettenhall RE,"Protein active in humoral hypercalcemia of malignancy-PthrP",issued October 24, 1995, assigned to University of Melbourne
  6. 1 2 Miao, D.; He, B.; Jiang, Y.; Kobayashi, T.; Sorocéanu, M. A.; Zhao, J.; et al. (September 2005). "Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34". The Journal of Clinical Investigation. 115 (9): 2402–2411. doi:10.1172/JCI24918. PMC   1193882 . PMID   16138191.
  7. ↑ Sims, Natalie A. "Natalie A Sims's Lab". ResearchGate .
  8. ↑ Martin, Thomas J. "Thomas Martin - Saint Vincent's Institute". ResearchGate . Archived from the original on August 11, 2022. Retrieved October 29, 2022.
  9. ↑ "Prof Thomas Martin". Find an Expert - University of Melbourne . Archived from the original on November 4, 2022. Retrieved October 29, 2022.
  10. 1 2 3 "2022 TJ Martin Medal Award Winner". ACMD. Archived from the original on October 30, 2022. Retrieved October 30, 2022.
  11. ↑ Martin TJ (September 2005). "Osteoblast-derived PTHrP is a physiological regulator of bone formation". The Journal of Clinical Investigation. 115 (9): 2322–2324. doi:10.1172/JCI26239. PMC   1193889 . PMID   16138187.
  12. 1 2 Isojima, Tsuyoshi; Walker, Emma C; Poulton, Ingrid J; McGregor, Narelle E; Wicks, Ian P; Gooi, Jonathan H; Martin, T John; Sims, Natalie A (July 20, 2022). "G-CSF Receptor Deletion Amplifies Cortical Bone Dysfunction in Mice With STAT3 Hyperactivation in Osteocytes" . Journal of Bone and Mineral Research. 37 (10): 1876–1890. doi:10.1002/jbmr.4654. ISSN   0884-0431.
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