Tra (gene)

Fruit fly transformer
Fruit fly transformer
Identifiers
Symbol	Transformer
Pfam	PF06495
InterPro	IPR010519
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Search for
Structures	Swiss-model
Domains	InterPro

Transformer
Transformer
Identifiers
Organism	Drosophila melanogaster
Symbol	tra
Alt. symbols	CG16724; Dmel\CG16724; Dmtra
Entrez	39849
RefSeq (mRNA)	NM_079390.3
RefSeq (Prot)	NP_524114.1
UniProt	P11596
Other data
Chromosome	3L: 16.58 - 16.58 Mb
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Last updated May 23, 2025

Transformer-2

Identifiers

Organism

Drosophila melanogaster

Symbol

tra2

UniProt

P19018

Search for
Structures	Swiss-model
Domains	InterPro

Female-specific protein transformer is a protein that in Drosophila melanogaster is encoded by the tra gene. Unlike the related tra2 protein, it is only produced in females.

The transformer protein controls female somatic sexual differentiation.^[2]^[3] The protein contains an RNA recognition motif. It controls the alternative splicing of the fly sex determination gene doublesex.^[1]

References

1 2 Verhulst EC, van de Zande L, Beukeboom LW (August 2010). "Insect sex determination: it all evolves around transformer" (PDF). Current Opinion in Genetics & Development. 20 (4): 376–83. doi:10.1016/j.gde.2010.05.001. hdl: 11370/2174764d-bd1b-4e1f-b142-90aced0c3e55 . PMID 20570131. S2CID 205003182.
↑ Boggs RT, Gregor P, Idriss S, Belote JM, McKeown M (August 1987). "Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene". Cell. 50 (5): 739–47. doi:10.1016/0092-8674(87)90332-1. PMID 2441872. S2CID 33918630.
↑ Li H, Bingham PM (October 1991). "Arginine/serine-rich domains of the su(wa) and tra RNA processing regulators target proteins to a subnuclear compartment implicated in splicing". Cell. 67 (2): 335–42. doi:10.1016/0092-8674(91)90185-2. PMID 1655279. S2CID 20307555.

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[dsx-1] 1 2 Verhulst EC, van de Zande L, Beukeboom LW (August 2010). "Insect sex determination: it all evolves around transformer" (PDF). Current Opinion in Genetics & Development. 20 (4): 376–83. doi:10.1016/j.gde.2010.05.001. hdl: 11370/2174764d-bd1b-4e1f-b142-90aced0c3e55 . PMID 20570131. S2CID 205003182.

[pmid2441872-2] Boggs RT, Gregor P, Idriss S, Belote JM, McKeown M (August 1987). "Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene". Cell. 50 (5): 739–47. doi:10.1016/0092-8674(87)90332-1. PMID 2441872. S2CID 33918630.

[pmid1655279-3] Li H, Bingham PM (October 1991). "Arginine/serine-rich domains of the su(wa) and tra RNA processing regulators target proteins to a subnuclear compartment implicated in splicing". Cell. 67 (2): 335–42. doi:10.1016/0092-8674(91)90185-2. PMID 1655279. S2CID 20307555.

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