Translational efficiency

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In cell biology, translational efficiency or translation efficiency is the rate of mRNA translation into proteins within cells.

Contents

It has been measured in protein per mRNA per hour. [1] Several RNA elements within mRNAs have been shown to affect the rate. These include miRNA and protein binding sites. RNA structure may also affect translational efficiency through the altered protein or microRNA binding. [2]

See also

References

  1. ↑ Schwanhäusser, Björn; Busse, Dorothea; Li, Na; Dittmar, Gunnar; Schuchhardt, Johannes; Wolf, Jana; Chen, Wei; Selbach, Matthias (May 2011). "Global quantification of mammalian gene expression control" (PDF). Nature. 473 (7347): 337–342. Bibcode:2011Natur.473..337S. doi:10.1038/nature10098. PMID   21593866. S2CID   205224972.
  2. ↑ Lu, YF; Mauger, DM; Goldstein, DB; Urban, TJ; Weeks, KM; Bradrick, SS (4 November 2015). "IFNL3 mRNA structure is remodeled by a functional non-coding polymorphism associated with hepatitis C virus clearance". Scientific Reports. 5 16037. Bibcode:2015NatSR...516037L. doi:10.1038/srep16037. PMC   4631997 . PMID   26531896.


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