Transmembrane protein 175

Transmembrane protein 175
Identifiers
Symbol	TMEM175
Pfam	PF06736
InterPro	IPR010617
TCDB	1.A.78
OPM superfamily	467
OPM protein	5vre
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Transmembrane protein 175
Identifiers
Symbol	TMEM175
Alt. symbols	MGC4618
NCBI gene	84286
HGNC	28709
RefSeq	NM_032326
UniProt	Q9BSA9
Other data
Locus	Chr. 4 p16.3
Search for Structures Swiss-model Domains InterPro

Transmembrane protein 175, or TMEM175, is a transmembrane protein that is thought to be an endolysosomal potassium channel. It is predicted to have many orthologs across eukaryotes.

Expression

Based on human and mouse EST profiles and a human tissue GEO profile, TMEM175 appears to be expressed at a relatively high level (75-98%) in normal tissues. ^{[1] [2]} TMEM175 appears to be down regulated in stage three ovarian cancer. ^[3]

Homology

Transmembrane protein 175 has no paralogs. It does have orthologs within eukaryotes. The following table presents some of the orthologs found using searches in BLAST ^[4] and BLAT. ^[5] This list does not contain all of the orthologs for TMEM175. It is meant to display the diversity of species for which orthologs are found.

Scientific name	Common Name	Accession Number	Sequence Length	Percent Identity	Percent Similarity
Homo Sapiens	Human	NP_115702.1	504	-	-
Pan troglodytes	Chimp	XP_001141076	504	92	93
Pongo abelii	Orangutan	XP_002814537	231	99	99
Macaca mulatta	Rhesus	XP_001085173.1	403	96	98
Callithrix jacchus	Marmoset	XP_002746113.1	472	83	87
Bos taurus	Cow	NP_001069081.1	479	77	82
Ailuropoda melanoleuca	Panda	XP_002924455.1	498	81	87
Equus caballus	Horse	XP_001488271.1	499	81	86
Rattus norvegicus	Rat	NP_001014013.1	499	82	88
Mus musculus	Mouse	NP_082499.3	499	81	88
Monodelphis domestica	Opossum	XP_001377424.1	502	67	80
Ornithorhynchus anatinus	Platypus	XP_001514176	499	68	82
Gallus gallus	Chicken	NP_001006582.1	501	64	78
Sceloporus occidentalis	Lizard	-	417	56	66
Taeniopygia guttata	Zebra Finch	XP_002187908.1	496	66	79
Danio rerio	Zebra Fish	NP_001093545.1	520	62	76
Branchiostoma floridae	Lancelet	XP_002596272	409	31	50
Ciona intestinalis	Sea Squirt	XP_002122718	494	27	50
Nematostella vectensis	Starlet Sea Anemone	XP_001630719	489	28	49

Predicted Post-Translational Modification

Using various tools at ExPASy ^[6] the following are possible post-translational modifications for TMEM175.

• 5 possible CK2 phosphorylation sites
• 2 possible PKC phosphorylation sites
• N-myristoylation sites around transmembrane regions

The N-myristoylation sites are conserved in vertebrates.

References

1. EST Profile Viewer- Human
2. EST Profile Viewer- Mouse
3. [Partheen K, Levan K, Osterberg L, Horvath G (November 2006). "Expression analysis of stage III serous ovarian adenocarcinoma distinguishes a sub-group of survivors". European Journal of Cancer. 42 (16): 2846–54. doi:10.1016/j.ejca.2006.06.026. PMID   16996261.
4. NCBI BLAST: Basic Local Alignment Search Tool
5. BLAT Search Genome ^{[ permanent dead link ]}
6. ExPASy Proteomics Server

Further reading

• "Genetic study of Lewy body dementia supports ties to Alzheimer's and Parkinson's diseases". National Institutes of Health (NIH). 2021-02-16. Retrieved 2023-08-07.