Tsukushi (protein)

Last updated
TSKU
Identifiers
Aliases TSKU , E2IG4, LRRC54, TSK, tsukushi, small leucine rich proteoglycan
External IDs OMIM: 608015 MGI: 2443855 HomoloGene: 41045 GeneCards: TSKU
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001258210
NM_015516
NM_001318477
NM_001318478
NM_001318479

NM_001024619
NM_001168539
NM_001168540
NM_001168541

RefSeq (protein)

NP_001245139
NP_001305406
NP_001305407
NP_001305408
NP_056331

NP_001019790
NP_001162011
NP_001162012
NP_001162013

Location (UCSC) Chr 11: 76.78 – 76.8 Mb Chr 7: 98.35 – 98.36 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tsukushi or tsukushin is an extracellular matrix protein of the small leucine rich proteoglycan (SLRP) family. In humans it is encoded by the TSKU gene. [5]

Tsukushi is a non-canonical class IV SLRP. [6] It is involved in early animal development. [7]

Related Research Articles

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Proteoglycans are proteins that are heavily glycosylated. The basic proteoglycan unit consists of a "core protein" with one or more covalently attached glycosaminoglycan (GAG) chain(s). The point of attachment is a serine (Ser) residue to which the glycosaminoglycan is joined through a tetrasaccharide bridge. The Ser residue is generally in the sequence -Ser-Gly-X-Gly-, although not every protein with this sequence has an attached glycosaminoglycan. The chains are long, linear carbohydrate polymers that are negatively charged under physiological conditions due to the occurrence of sulfate and uronic acid groups. Proteoglycans occur in connective tissue.

Decorin

Decorin is a protein that in humans is encoded by the DCN gene.

Biglycan

Biglycan is a small leucine-rich repeat proteoglycan (SLRP) which is found in a variety of extracellular matrix tissues, including bone, cartilage and tendon. In humans, biglycan is encoded by the BGN gene which is located on the X chromosome.

Lumican

Lumican, also known as LUM, is an extracellular matrix protein that, in humans, is encoded by the LUM gene on chromosome 12.

Keratocan

Keratocan (KTN) also known as keratan sulfate proteoglycan keratocan, is a protein that in humans is encoded by the KERA gene.

WNT1-inducible-signaling pathway protein 1

WNT1-inducible-signaling pathway protein 1 (WISP-1), also known as CCN4, is a matricellular protein that in humans is encoded by the WISP1 gene.

Fibromodulin

Fibromodulin is a protein that in humans is encoded by the FMOD gene.

Nyctalopin

Nyctalopin is a protein located on the surface of photoreceptor-to-ON bipolar cell synapse in the retina. It is composed of 481 amino acids. and is encoded in human by the NYX gene. This gene is found on the chromosome X and has two exons. This protein is a leucine-rich proteoglycan which is expressed in the eye, spleen and brain in mice. Mutations in this gene cause congenital stationary night blindness in humans (CSNB). which is a stable retinal disorder. The consequence of this mutation results in an abnormal night vision. Nyctalopin is critical due to the fact that it generates a depolarizing bipolar cell response due to the mutation on the NYX gene. Most of the time, CSNB are associated to hygh myopia which is the result of a mutation on the same gene. Several mutations can occur on the NYX gene resulting on many form of night blindness in humans. Some studies show that these mutations are more present in Asian population than in Caucasian population. A mouse strain called nob carries a spontaneous mutation leading to a frameshift in this gene. These mice are used as an animal model for congenital stationary night blindness.

Prolargin

Prolargin is a protein that in humans is encoded by the PRELP gene.

B4GALT7

Beta-1,4-galactosyltransferase 7 also known as galactosyltransferase I is an enzyme that in humans is encoded by the B4GALT7 gene. Galactosyltransferase I catalyzes the synthesis of the glycosaminoglycan-protein linkage in proteoglycans. Proteoglycans in turn are structural components of the extracellular matrix that is found between cells in connective tissues.

Opticin

Opticin is a protein that in humans is encoded by the OPTC gene.

IMPG1

Interphotoreceptor matrix proteoglycan 1 is a protein that in humans is encoded by the IMPG1 gene.

Asporin

Asporin is a protein that in humans is encoded by the ASPN gene.

Osteomodulin

Osteomodulin is a protein that in humans is encoded by the OMD gene.

FLRT3

Leucine-rich repeat transmembrane protein FLRT3 is a protein that in humans is encoded by the FLRT3 gene.

FLRT2

Fibronectin leucine-rich repeat transmembrane protein FLRT2 is a protein that in humans is encoded by the FLRT2 gene.

LRRC17

Leucine-rich repeat-containing protein 17 is a protein that in humans is encoded by the LRRC17 gene.

LRRC50

Leucine-rich repeat-containing protein 50 is a protein that in humans is encoded by the LRRC50 gene.

Leucine rich repeat containing 15

Leucine rich repeat containing 15 is a protein that in humans is encoded by the LRRC15 gene.

FLRT1

Fibronectin leucine rich transmembrane protein 1 is a protein that in humans is encoded by the FLRT1 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000182704 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049580 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Tsukushi, small leucine rich proteoglycan" . Retrieved 2018-02-01.
  6. Iozzo, Renato V.; Schaefer, Liliana (March 2015). "Proteoglycan form and function: A comprehensive nomenclature of proteoglycans". Matrix Biology. 42: 11–55. doi: 10.1016/j.matbio.2015.02.003 . PMC   4859157 . PMID   25701227.
  7. Ohta, Kunimasa; Lupo, Giuseppe; Kuriyama, Sei; Keynes, Roger; Holt, Christine E.; Harris, William A.; Tanaka, Hideaki; Ohnuma, Shin-ichi (September 2004). "Tsukushi Functions as an Organizer Inducer by Inhibition of BMP Activity in Cooperation with Chordin". Developmental Cell. 7 (3): 347–358. doi:10.1016/j.devcel.2004.08.014. PMC   3793302 . PMID   15363410.

Further reading