Tsukushi (protein)

TSKU
Identifiers
Aliases	TSKU , E2IG4, LRRC54, TSK, tsukushi, small leucine rich proteoglycan
External IDs	OMIM: 608015 MGI: 2443855 HomoloGene: 41045 GeneCards: TSKU
Gene location (Human)
Chr.	Chromosome 11 (human)
End	76,798,153 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	98,010,535 bp
RNA expression pattern
	Top expressed in
	canal of the cervix; ; left uterine tube; ; gastric mucosa; ; right lobe of liver; ; subcutaneous adipose tissue; ; vagina; ; skin of abdomen; ; tibial nerve; ; vena cava; ; vulva;
	Top expressed in
	gallbladder; ; respiratory epithelium; ; olfactory epithelium; ; lip; ; ankle joint; ; duodenum; ; superior surface of tongue; ; esophagus; ; corneal stroma; ; yolk sac;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity ;
Cellular component	extracellular region ; extracellular space ; plasma membrane ;
Biological process	anterior commissure morphogenesis ; regulation of gene expression ; negative regulation of Wnt signaling pathway ; corpus callosum morphogenesis ; camera-type eye development ; ciliary body morphogenesis ; lateral ventricle development ; adenylate cyclase-modulating G protein-coupled receptor signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	25987
	244152
	ENSG00000182704
	ENSMUSG00000049580
	Q8WUA8
	Q8CBR6
	NM_001258210 ; NM_015516 ; NM_001318477 ; NM_001318478 ; NM_001318479
	NM_001024619 ; NM_001168539 ; NM_001168540 ; NM_001168541
	NP_001245139 ; NP_001305406 ; NP_001305407 ; NP_001305408 ; NP_056331
	NP_001019790 ; NP_001162011 ; NP_001162012 ; NP_001162013
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Tsukushi or tsukushin is an extracellular matrix protein of the small leucine rich proteoglycan (SLRP) family. In humans it is encoded by the TSKU gene.^[5]

Tsukushi is a non-canonical class IV SLRP.^[6] It is involved in early animal development.^[7]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000182704 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049580 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Tsukushi, small leucine rich proteoglycan" . Retrieved 2018-02-01.
↑ Iozzo, Renato V.; Schaefer, Liliana (March 2015). "Proteoglycan form and function: A comprehensive nomenclature of proteoglycans". Matrix Biology. 42: 11–55. doi: 10.1016/j.matbio.2015.02.003 . PMC 4859157 . PMID 25701227.
↑ Ohta, Kunimasa; Lupo, Giuseppe; Kuriyama, Sei; Keynes, Roger; Holt, Christine E.; Harris, William A.; Tanaka, Hideaki; Ohnuma, Shin-ichi (September 2004). "Tsukushi Functions as an Organizer Inducer by Inhibition of BMP Activity in Cooperation with Chordin". Developmental Cell. 7 (3): 347–358. doi:10.1016/j.devcel.2004.08.014. PMC 3793302 . PMID 15363410.

Tsukushi (protein)

Related Research Articles

References

Further reading