USP34

USP34
Identifiers
Aliases	USP34 , ubiquitin specific peptidase 34
External IDs	OMIM: 615295 MGI: 109473 HomoloGene: 40978 GeneCards: USP34
Gene location (Human)
Chr.	Chromosome 2 (human)
End	61,471,087 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	23,440,560 bp
RNA expression pattern
	Top expressed in
	nipple; ; renal medulla; ; cardia; ; pylorus; ; ventral tegmental area; ; trigeminal ganglion; ; superior surface of tongue; ; inferior ganglion of vagus nerve; ; external globus pallidus; ; sperm;
	Top expressed in
	superior cervical ganglion; ; conjunctival fornix; ; barrel cortex; ; vas deferens; ; spermatocyte; ; substantia nigra; ; entorhinal cortex; ; condyle; ; hair follicle; ; fossa;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ; cysteine-type endopeptidase activity ; cysteine-type peptidase activity ; peptidase activity ; hydrolase activity ; thiol-dependent deubiquitinase ;
Cellular component	cytosol ;
Biological process	proteolysis ; ubiquitin-dependent protein catabolic process ; positive regulation of canonical Wnt signaling pathway ; protein K48-linked deubiquitination ; Wnt signaling pathway ; protein deubiquitination ; regulation of protein stability ;
	Sources:Amigo / QuickGO
Orthologs
	9736
	17847
	ENSG00000115464
	ENSMUSG00000056342
	Q70CQ2
	Q6ZQ93
	NM_014709
	NM_001190401
	NP_055524
	NP_001177330
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Ubiquitin carboxyl-terminal hydrolase 34 is an enzyme that in humans is encoded by the USP34 gene.^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000115464 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056342 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
↑ "Entrez Gene: USP34 ubiquitin specific peptidase 34".

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID 12168954.
Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi: 10.1093/dnares/5.1.31 . PMID 9628581.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi: 10.1093/dnares/5.5.277 . PMID 9872452.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Quesada V, Díaz-Perales A, Gutiérrez-Fernández A, et al. (2004). "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases". Biochem. Biophys. Res. Commun. 314 (1): 54–62. doi:10.1016/j.bbrc.2003.12.050. PMID 14715245.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi: 10.1074/mcp.M400085-MCP200 . PMID 15345747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000115464 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056342 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12838346-5] Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.

[entrez-6] "Entrez Gene: USP34 ubiquitin specific peptidase 34".

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USP34

Related Research Articles

References

Further reading