USP40

USP40
Identifiers
Aliases	USP40 , ubiquitin specific peptidase 40
External IDs	OMIM: 610570 MGI: 2443184 HomoloGene: 32400 GeneCards: USP40
Gene location (Human)
Chr.	Chromosome 2 (human)
End	233,566,782 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	88,008,551 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; right uterine tube; ; Achilles tendon; ; sural nerve; ; skin of abdomen; ; left adrenal gland; ; right lobe of liver; ; body of stomach; ; corpus callosum;
	Top expressed in
	hand; ; spermatocyte; ; mirror; ; fossa; ; condyle; ; Paneth cell; ; jejunum; ; ascending aorta; ; maxillary prominence; ; neural tube;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	thiol-dependent deubiquitinase ; peptidase activity ; cysteine-type peptidase activity ; hydrolase activity ; cysteine-type endopeptidase activity ;
Cellular component	cytoplasm ; nucleus ; cytosol ;
Biological process	protein deubiquitination ; ubiquitin-dependent protein catabolic process ; proteolysis ; regulation of protein stability ;
	Sources:Amigo / QuickGO
Orthologs
	55230
	227334
	ENSG00000085982
	ENSMUSG00000005501
	Q9NVE5
	Q8BWR4
	NM_018218 ; NM_001365479
	NM_001033291 ; NM_001198573
NP_060688 ; NP_001352408 ; NP_001369224 ; NP_001369225 ; NP_001369226 ;
	NP_001369227 ; NP_001369228 ; NP_001369229 ; NP_001369230 ; NP_001369231 ; NP_001369232
	NP_001028463 ; NP_001185502
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 04, 2023

Ubiquitin carboxyl-terminal hydrolase 40 is an enzyme that in humans is encoded by the USP40 gene.^[5]^[6]

Related Research Articles

Ubiquitin carboxyl-terminal hydrolase 16 is an enzyme that in humans is encoded by the USP16 gene.

Ubiquitin specific protease 4 (USP4) is an enzyme that cleaves ubiquitin from a number of protein substrates. Prior to the standardization of nomenclature USP4 was known as UNP, and was one of the first deubiquitinating enzymes to be identified in mammals. In the mouse and human the USP4 protein is encoded by a gene containing 22 exons.

Ubiquitin thioesterase OTUB1 also known as otubain-1 is an enzyme that in humans is encoded by the OTUB1 gene. Alternative splicing results in multiple transcript variants.

Ubiquitin-specific protease 36 is an enzyme that in humans is encoded by the USP36 gene.

Ubiquitin carboxyl-terminal hydrolase 15 is an enzyme that in humans is encoded by the USP15 gene.

Ubiquitin carboxyl-terminal hydrolase 24 is an enzyme that in humans is encoded by the USP24 gene.

Ubiquitin carboxyl-terminal hydrolase 47 is an enzyme that in humans is encoded by the USP47 gene.

Ubiquitin specific processing protease 37 is an enzyme that in humans, is encoded by the USP37 gene.

U4/U6.U5 tri-snRNP-associated protein 2 is a protein that in humans is encoded by the USP39 gene.

E3 ubiquitin-protein ligase MARCH7 is an enzyme that in humans is encoded by the MARCH7 gene.

Ubiquitin carboxyl-terminal hydrolase 44 is an enzyme that in humans is encoded by the USP44 gene.

Ubiquitin carboxyl-terminal hydrolase 48 is an enzyme that in humans is encoded by the USP48 gene.

Ubiquitin carboxyl-terminal hydrolase 2 is an enzyme that in humans is encoded by the USP2 gene.

Ubiquitin carboxyl-terminal hydrolase 13 is an enzyme that in humans is encoded by the USP13 gene.

THAP domain-containing protein 4 is a protein that in humans is encoded by the THAP4 gene.

Ubiquitin-fold modifier 1, also known as UFM1, is a protein which in humans is encoded by the UFM1 gene.

Ubiquitin carboxyl-terminal hydrolase 34 is an enzyme that in humans is encoded by the USP34 gene.

Ubiquitin carboxyl-terminal hydrolase 51 is an enzyme that in humans is encoded by the USP51 gene.

Ubiquitin carboxyl-terminal hydrolase 42 is an enzyme that in humans is encoded by the USP42 gene.

Putative ATP-dependent RNA helicase DHX57 is an enzyme that in humans is encoded by the DHX57 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000085982 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005501 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
↑ "Entrez Gene: USP40 ubiquitin specific peptidase 40".

Bass BL (2002). "RNA editing by adenosine deaminases that act on RNA". Annu. Rev. Biochem. 71 (1): 817–46. doi:10.1146/annurev.biochem.71.110601.135501. PMC 1823043 . PMID 12045112.
Chen X, Zhang Y, Douglas L, Zhou P (2002). "UV-damaged DNA-binding proteins are targets of CUL-4A-mediated ubiquitination and degradation". J. Biol. Chem. 276 (51): 48175–82. doi: 10.1074/jbc.M106808200 . PMID 11673459.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Quesada V, Díaz-Perales A, Gutiérrez-Fernández A, et al. (2004). "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases". Biochem. Biophys. Res. Commun. 314 (1): 54–62. doi:10.1016/j.bbrc.2003.12.050. PMID 14715245.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID 15815621.
Li Y, Schrodi S, Rowland C, et al. (2006). "Genetic evidence for ubiquitin-specific proteases USP24 and USP40 as candidate genes for late-onset Parkinson disease". Hum. Mutat. 27 (10): 1017–23. doi: 10.1002/humu.20382 . PMID 16917932. S2CID 43881832.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000085982 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005501 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12838346-5] Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.

[entrez-6] "Entrez Gene: USP40 ubiquitin specific peptidase 40".

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USP40

Related Research Articles

References

Further reading