USP52

PAN2
Identifiers
Aliases	PAN2 , USP52, PAN2 poly(A) specific ribonuclease subunit, poly(A) specific ribonuclease subunit PAN2
External IDs	OMIM: 617447; MGI: 1918984; HomoloGene: 5918; GeneCards: PAN2; OMA:PAN2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q13.3 Start 56,316,223 bp [1] End 56,334,053 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 D3 Start 128,139,204 bp [2] End 128,157,227 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland left lobe of thyroid gland right hemisphere of cerebellum right uterine tube left ovary anterior pituitary right ovary body of pancreas right testis left testis Top expressed in secondary oocyte zygote primary oocyte tail of embryo genital tubercle neural layer of retina granulocyte hair follicle endocardial cushion epithelium of lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function poly(A)-specific ribonuclease activity nuclease activity exonuclease activity 3'-5'-exoribonuclease activity protein binding hydrolase activity nucleic acid binding metal ion binding Cellular component cytoplasm PAN complex cytosol P-body nucleus Biological process nuclear-transcribed mRNA poly(A) tail shortening mRNA processing nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, exonucleolytic nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay positive regulation of cytoplasmic mRNA processing body assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9924 103135 Ensembl ENSG00000135473 ENSMUSG00000005682 UniProt Q504Q3 Q8BGF7 RefSeq (mRNA) NM_014871 NM_001127460 NM_001166279 NM_001252326 NM_001252327 NM_133992 NM_001358822 RefSeq (protein) NP_001120932 NP_001159751 NP_055686 NP_001239255 NP_001239256 NP_598753 NP_001345751 Location (UCSC) Chr 12: 56.32 – 56.33 Mb Chr 10: 128.14 – 128.16 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

PAB-dependent poly(A)-specific ribonuclease subunit 2 is an enzyme that in humans is encoded by the PAN2 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000135473 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005682 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Puente XS, Sánchez LM, Overall CM, López-Otín C (July 2003). "Human and mouse proteases: a comparative genomic approach". Nature Reviews. Genetics. 4 (7): 544–58. doi:10.1038/nrg1111. PMID   12838346. S2CID   2856065.
6. Uchida N, Hoshino S, Katada T (January 2004). "Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein". The Journal of Biological Chemistry. 279 (2): 1383–91. doi: 10.1074/jbc.M309125200 . PMID   14583602.
7. "Entrez Gene: USP52 ubiquitin specific peptidase 52".

Further reading

• Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID   9734811.
• Lo KW, Naisbitt S, Fan JS, Sheng M, Zhang M (April 2001). "The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif". The Journal of Biological Chemistry. 276 (17): 14059–66. doi: 10.1074/jbc.M010320200 . PMID   11148209.
• Quesada V, Díaz-Perales A, Gutiérrez-Fernández A, Garabaya C, Cal S, López-Otín C (January 2004). "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases". Biochemical and Biophysical Research Communications. 314 (1): 54–62. doi:10.1016/j.bbrc.2003.12.050. PMID   14715245.
• Yamashita A, Chang TC, Yamashita Y, Zhu W, Zhong Z, Chen CY, Shyu AB (December 2005). "Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover". Nature Structural & Molecular Biology. 12 (12): 1054–63. doi:10.1038/nsmb1016. PMID   16284618. S2CID   19485927.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.