Ubiquitin specific peptidase 38

Last updated
USP38
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases USP38 , HP43.8KD, ubiquitin specific peptidase 38
External IDs MGI: 1922091 HomoloGene: 12367 GeneCards: USP38
Gene location (Human)
Ideogram human chromosome 4.svg
Chr. Chromosome 4 (human) [1]
Human chromosome 4 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 4q31.21Start143,184,917 bp [1]
End143,223,830 bp [1]
Orthologs
SpeciesHumanMouse
Entrez

84640

74841

Ensembl

ENSG00000170185

ENSMUSG00000038250

UniProt

Q8NB14

Q8BW70

RefSeq (mRNA)

NM_001290325
NM_001290326
NM_032557

NM_027554

RefSeq (protein)

NP_001277254
NP_001277255
NP_115946

NP_081830

Location (UCSC) Chr 4: 143.18 – 143.22 Mb Chr 8: 80.98 – 81.01 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin specific peptidase 38 is a protein that in humans is encoded by the USP38 gene. [5]

Protein biological molecule consisting of chains of amino acid residues

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific three-dimensional structure that determines its activity.

Gene basic physical and functional unit of heredity

In biology, a gene is a sequence of nucleotides in DNA or RNA that codes for a molecule that has a function. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic trait. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes as well as gene–environment interactions. Some genetic traits are instantly visible, such as eye color or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that constitute life.

Related Research Articles

USP9Y protein-coding gene in the species Homo sapiens

Ubiquitin specific peptidase 9, Y-linked , also known as USP9Y, is an enzyme which in humans is encoded by the USP9Y gene. It is required for sperm production. This enzyme is a member of the peptidase C19 family and is similar to ubiquitin-specific proteases, which cleave the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins.

USP18 protein-coding gene in the species Homo sapiens

Ubiquitin specific peptidase 18 (USP18), also known as UBP43, is an isopeptidase that in human is encoded by the USP18 gene. USP18 is a member of the deubiquitinating protease family of enzymes. It is thought to remove ISG15 adducts from a broad range of protein substrates, a process known as deISGylation. In mice, deletion of this enzyme results in increased inflammatory response to type I interferons, suggesting that USP18 may, in part, regulate interferon responsiveness.

USP44 protein-coding gene in the species Homo sapiens

Ubiquitin carboxyl-terminal hydrolase 44 is an enzyme that in humans is encoded by the USP44 gene.

USP48 protein-coding gene in the species Homo sapiens

Ubiquitin carboxyl-terminal hydrolase 48 is an enzyme that in humans is encoded by the USP48 gene.

USP13 protein-coding gene in the species Homo sapiens

Ubiquitin carboxyl-terminal hydrolase 13 is an enzyme that in humans is encoded by the USP13 gene.

USP14 protein-coding gene in the species Homo sapiens

Ubiquitin-specific protease 14 is an enzyme that in humans is encoded by the USP14 gene.

USP52 protein-coding gene in the species Homo sapiens

PAB-dependent poly(A)-specific ribonuclease subunit 2 is an enzyme that in humans is encoded by the PAN2 gene.

USP40 protein-coding gene in the species Homo sapiens

Ubiquitin carboxyl-terminal hydrolase 40 is an enzyme that in humans is encoded by the USP40 gene.

USP34 protein-coding gene in the species Homo sapiens

Ubiquitin carboxyl-terminal hydrolase 34 is an enzyme that in humans is encoded by the USP34 gene.

USP51 protein-coding gene in the species Homo sapiens

Ubiquitin carboxyl-terminal hydrolase 51 is an enzyme that in humans is encoded by the USP51 gene.

USP42 protein-coding gene in the species Homo sapiens

Ubiquitin carboxyl-terminal hydrolase 42 is an enzyme that in humans is encoded by the USP42 gene.

UBL7 protein-coding gene in the species Homo sapiens

Ubiquitin-like 7 is a protein in humans that is encoded by the UBL7 gene.

USP19 protein-coding gene in the species Homo sapiens

Ubiquitin specific peptidase 19 is a protein that in humans is encoded by the USP19 gene.

Neuralized e3 ubiquitin protein ligase 3 protein-coding gene in the species Homo sapiens

Neuralized E3 ubiquitin protein ligase 3 is a protein that in humans is encoded by the NEURL3 gene.

Ubiquitin conjugating enzyme E2 F (putative) protein-coding gene in the species Homo sapiens

Ubiquitin conjugating enzyme E2 F (putative) is a protein that in humans is encoded by the UBE2F gene.

Ubiquitin specific peptidase 54 protein-coding gene in the species Homo sapiens

Ubiquitin specific peptidase 54 is a protein that in humans is encoded by the USP54 gene.

USP25 protein-coding gene in the species Homo sapiens

Ubiquitin specific peptidase 25 is a protein that in humans is encoded by the USP25 gene.

Zinc finger containing ubiquitin peptidase 1 protein-coding gene in the species Homo sapiens

Zinc finger containing ubiquitin peptidase 1 is a protein that in humans is encoded by the ZUP1 gene.

Peptidase inhibitor 15 protein-coding gene in the species Homo sapiens

Peptidase inhibitor 15 is a protein that in humans is encoded by the PI15 gene.

Serine protease 57 protein-coding gene in the species Homo sapiens

Serine protease 57 is a protein that in humans is encoded by the PRSS57 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000170185 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038250 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: Ubiquitin specific peptidase 38" . Retrieved 2016-08-22.

Further reading


This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.