Virapinib

Virapinib

Identifiers
IUPAC name [3-[7-methyl-4-(methylamino)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-yl]pyrrolidin-1-yl]-[4-(4-methylpiperidin-1-yl)phenyl]methanone
CAS Number	1794091-10-3
PubChem CID	127251916
ChemSpider	29964516
Chemical and physical data
Formula	C26H36N6O
Molar mass	448.615 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1CCN(CC1)C2=CC=C(C=C2)C(=O)N3CCC(C3)C4=NC5=C(CCN(C5)C)C(=N4)NC
InChI InChI=1S/C26H36N6O/c1-18-8-13-31(14-9-18)21-6-4-19(5-7-21)26(33)32-15-10-20(16-32)24-28-23-17-30(3)12-11-22(23)25(27-2)29-24/h4-7,18,20H,8-17H2,1-3H3,(H,27,28,29) Key:LUAVWTOZVHIDSI-UHFFFAOYSA-N

Virapinib is an antiviral drug which is the first drug developed that acts by inhibiting viral entry into cells via macropinocytosis. While it is only in early developmental stages, initial testing showed broad spectrum antiviral activity against a range of viruses including SARS-CoV-2, Monkeypox virus, Ebolavirus and tick-borne encephalitis virus. ^[1]

References

1. Porebski B, Christ W, Corman A, Haraldsson M, Barz M, Lidemalm L, et al. (July 2024). "Discovery of a novel inhibitor of macropinocytosis with antiviral activity". Molecular Therapy. doi: 10.1016/j.ymthe.2024.06.038 . hdl: 10902/34119 . PMC   11403221 . PMID   38956870.