WD repeat and HMG-box DNA binding protein 1 is a protein in humans that is encoded by the WDHD1 gene. [5]
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific three-dimensional structure that determines its activity.
WD repeat and HMG-box DNA binding protein 1 is a protein in humans that is encoded by the WDHD1 gene.
In biology, a gene is a sequence of nucleotides in DNA or RNA that codes for a molecule that has a function. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic trait. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes as well as gene–environment interactions. Some genetic traits are instantly visible, such as eye color or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that constitute life.
The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. WD40 domains are found in a variety of eukaryotic proteins and may function as adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
In bone physiology, the N-terminal telopeptide is a telopeptide that can be used as a biomarker to measure the rate of bone turnover. NTX can be measured in the urine (uNTX) or serum.
C-terminal-binding protein 1 also known as CtBP1 is a protein that in humans is encoded by the CTBP1 gene.
Transduction is the process by which foreign DNA is introduced into a cell by a virus or viral vector. An example is the viral transfer of DNA from one bacterium to another and hence an example of horizontal gene transfer. Transduction does not require physical contact between the cell donating the DNA and the cell receiving the DNA, and it is DNase resistant. Transduction is a common tool used by molecular biologists to stably introduce a foreign gene into a host cell's genome.
High-mobility group protein B2 also known as high-mobility group protein 2 (HMG-2) is a protein that in humans is encoded by the HMGB2 gene.
WD repeat-containing protein 8 is a protein that in humans is encoded by the WDR8 gene.
WD repeat-containing protein 33 is a protein that in humans is encoded by the WDR33 gene.
WD repeat-containing protein 1 is a protein that in humans is encoded by the WDR1 gene.
F-box/WD repeat-containing protein 2 is a protein that in humans is encoded by the FBXW2 gene.
Forkhead box protein K2 is a protein that in humans is encoded by the FOXK2 gene.
F-box/LRR-repeat protein 7 is a protein that in humans is encoded by the FBXL7 gene.
Putative RNA-binding protein Luc7-like 1 is a protein that in humans is encoded by the LUC7L gene.
SOX12 is a protein that in humans is encoded by the SOX12 gene. Sox12 belongs to the SoxC group of Sox family of transcription factors, together with Sox4 and Sox11. Sox12-null knockout mice appear normal, unlike Sox4 or Sox11 knockout mice. This probably comes from functional redundancy with Sox4 and Sox11. Sox12 is a weaker activator than both Sox4 and Sox11 in mouse.
F-box only protein 6 is a protein that in humans is encoded by the FBXO6 gene.
Guanine nucleotide-binding protein subunit beta-like protein 1 is a protein that in humans is encoded by the GNB1L gene.
WD repeat-containing protein 11 (WDR11) also known as bromodomain and WD repeat-containing protein 2 (BRWD2) is a protein that in humans is encoded by the WDR11 gene.
WD repeat-containing protein 26 is a protein that in humans is encoded by the WDR26 gene.
Thymocyte selection-associated high mobility group box protein TOX is a protein that in humans is encoded by the TOX gene.
F-box/WD repeat-containing protein 10 is a protein that in humans is encoded by the FBXW10 gene.
Ankyrin repeat and SOCS box protein 6 is a protein that in humans is encoded by the ASB6 gene.
Coronin, actin binding protein, 2A is a protein that in humans is encoded by the CORO2A gene.
HMG-box containing 3 is a protein that in humans is encoded by the HMGXB3 gene.
F-box protein 16 is a protein that in humans is encoded by the FBXO16 gene.
WD repeat domain 18 is a protein that in humans is encoded by the WDR18 gene.
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