WDR4 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | WDR4 , TRM82, TRMT82, WD repeat domain 4, GAMOS6, MIGSB, hWH, Wuho | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 605924 MGI: 1889002 HomoloGene: 32422 GeneCards: WDR4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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tRNA (guanine-N(7)-)-methyltransferase subunit WDR4 is an enzyme subunit that in humans is encoded by the WDR4 gene. [5]
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.
This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Two transcript variants encoding the same protein have been found for this gene. [5]
WD repeat and SOCS box-containing protein 1 is a protein that in humans is encoded by the WSB1 gene.
Cleavage stimulation factor 77 kDa subunit is a protein that in humans is encoded by the CSTF3 gene.
40S ribosomal protein S24 is a protein that in humans is encoded by the RPS24 gene.
Mitochondrial import receptor subunit TOM34 is a protein that in humans is encoded by the TOMM34 gene.
Trafficking protein particle complex subunit 10 is a protein that in humans is encoded by the TRAPPC10 gene.
WD repeat-containing protein 1 is a protein that in humans is encoded by the WDR1 gene.
Integrator complex subunit 11 is a protein that in humans is encoded by the CPSF3L gene.
39S ribosomal protein L22, mitochondrial is a protein that in humans is encoded by the MRPL22 gene.
ATP synthase subunit O, mitochondrial is an enzyme that in humans is encoded by the ATP5PO gene.
39S ribosomal protein L20, mitochondrial is a protein that in humans is encoded by the MRPL20 gene.
Periodic tryptophan protein 2 homolog is a protein that in humans is encoded by the PWP2 gene.
39S ribosomal protein L1, mitochondrial is a protein that in humans is encoded by the MRPL1 gene.
WD repeat-containing protein 6 is a protein that in humans is encoded by the WDR6 gene.
39S ribosomal protein L4, mitochondrial is a protein that in humans is encoded by the MRPL4 gene.
28S ribosomal protein S6, mitochondrial is a protein that in humans is encoded by the MRPS6 gene.
39S ribosomal protein L32, mitochondrial is a protein that in humans is encoded by the MRPL32 gene.
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 is a protein that in humans is encoded by the ZRSR2 gene.
Subunit P of phosphatidylinositol N-acetylglucosaminyltransferase is an enzyme subunit that in humans is encoded by the PIGP gene.
39S ribosomal protein L37, mitochondrial is a protein that in humans is encoded by the MRPL37 gene.
Guanine nucleotide-binding protein subunit beta-like protein 1 is a protein that in humans is encoded by the GNB1L gene.