U.S. Route 222 is a U.S. Highway that is a spur of US 22 in the states of Maryland and Pennsylvania. It runs for 95 miles (153 km) from US 1 in Conowingo, Maryland, north to the junction of Interstate 78 (I-78) and Pennsylvania Route 309 in Dorneyville, Pennsylvania. US 222 is almost entirely in Pennsylvania, and serves as the state's principal artery between the Lancaster and Reading areas in the west and the Lehigh Valley in the east.
U.S. Route 522 is a spur route of US 22 in the states of Virginia, West Virginia, Maryland, and Pennsylvania. The U.S. Highway travels in a north-south direction, and runs 308.59 miles (496.63 km) from US 60 near Powhatan, Virginia, to its northern terminus at US 11 and US 15 near Selinsgrove, Pennsylvania. US 522 serves many small cities and towns in the Piedmont, Blue Ridge Mountains, and northern Shenandoah Valley of Virginia. The highway serves the Virginia communities of Goochland, Mineral, Culpeper, the town of Washington, and Front Royal and the independent city of Winchester. US 522 then follows the Ridge-and-Valley Appalachians north and then east through the Eastern Panhandle of West Virginia, a 2-mile-wide (3.2 km) stretch of Western Maryland, and South Central Pennsylvania to its terminus in the Susquehanna Valley. The highway serves Berkeley Springs, West Virginia; Hancock, Maryland; and the Pennsylvania communities of McConnellsburg, Mount Union, Lewistown, and Middleburg.
U.S. Route 340 is a spur route of US 40, and runs from Greenville, Virginia, to Frederick, Maryland. In Virginia, it runs north–south, parallel and east of US 11, from US 11 north of Greenville via Waynesboro, Grottoes, Elkton, Luray, Front Royal, and Berryville to the West Virginia state line. A short separate piece crosses northern Loudoun County on its way from West Virginia to Maryland.
West Virginia Route 45 is a state highway in the U.S. state of West Virginia. The state highway runs 25.8 miles (41.5 km) from the Virginia state line near Glengary east to WV 230 and WV 480 in Shepherdstown. WV 45 connects the communities of Glengary and Arden in southwestern Berkeley County with the county seat of Martinsburg. The state highway also connects Shepherdstown in northern Jefferson County with Martinsburg, where the highway meets Interstate 81 (I-81), U.S. Route 11, and WV 9.
Pennsylvania Route 29 is a 118-mile-long (190 km) north–south state highway that runs through most of eastern Pennsylvania.
The Mon–Fayette Expressway is a partially-completed controlled-access toll road that is planned to eventually link Interstate 68 near Morgantown, West Virginia with Interstate 376 near Monroeville, Pennsylvania. The ultimate goal of the highway is to provide a high speed north–south connection between Morgantown and the eastern side of Pittsburgh while revitalizing economically distressed Monongahela River Valley towns in Fayette and Washington counties, serving as an alternative to Interstate 79 to the west, as well as relieving the PA 51 alignment from Pittsburgh to Uniontown.
Maryland Route 144 is a collection of state highways in the U.S. state of Maryland. These highways are sections of old alignment of U.S. Route 40 between Cumberland and Baltimore. Along with US 40 Scenic, US 40 Alternate, and a few sections of county-maintained highway, MD 144 is assigned to what was once the main highway between the two cities, connecting those endpoints with Hancock, Hagerstown, Frederick, New Market, Mount Airy, Ellicott City, and Catonsville. MD 144 has seven disjoint sections of mainline highway that pass through the Appalachian Mountains in Allegany and Washington counties and the rolling Piedmont of Frederick, Carroll, Howard, and Baltimore counties.
Virginia State Route 311 and West Virginia Route 311 are adjoining state highways in the U.S. states of Virginia and West Virginia. The two state highways together run 58.7 miles (94.5 km) from U.S. Route 11 in Salem, Virginia north to Interstate 64 and U.S. Route 60 near White Sulphur Springs, West Virginia. The two Virginia portions of Route 311 are maintained by the Virginia Department of Transportation, with the exception of the city-maintained portion within Salem. The West Virginia segments are maintained by the West Virginia Division of Highways.
Pennsylvania Route 73 (PA 73) is a 62.32-mile (100.29 km) long east–west state highway in southeastern Pennsylvania. It runs from PA 61 near Leesport southeast to the New Jersey state line on the Tacony–Palmyra Bridge over the Delaware River in Philadelphia, where the road continues south as New Jersey Route 73. The route passes through rural areas of Berks County, crossing U.S. Route 222 (US 222) in Maiden Creek before heading southeast through Oley and Boyertown. PA 73 continues into Montgomery County and intersects PA 100 in Gilbertsville and PA 29 in Schwenksville before it heads into the northwest suburbs of Philadelphia. The route passes through Skippack and intersects US 202 in Center Square, PA 309 in Springfield Township, and PA 611 near Jenkintown. PA 73 continues through Northeast Philadelphia on Cottman Avenue, crossing US 1 and US 13 before coming to an interchange with Interstate 95 (I-95) near the Tacony–Palmyra Bridge.
Virginia State Route 9 is a primary state highway in the U.S. state of Virginia. Known as Charles Town Pike, the state highway runs 13.08 miles (21.05 km) from the West Virginia state line near Mechanicsville, where the highway continues west as West Virginia Route 9, east to SR 7 and SR 7 Business in Paeonian Springs. SR 9 is the main east–west highway of northwestern Loudoun County, connecting Leesburg with Hillsboro and the West Virginia cities of Charles Town and Martinsburg. As a result, the state highway and its West Virginia continuation are a major, overburdened commuter route between the Eastern Panhandle of West Virginia and Washington, D.C.
State Route 55 is a primary state highway in the U.S. state of Virginia. Known for most of its length as John Marshall Highway, the state highway runs 64.71 miles (104.14 km) from the West Virginia state line, where the highway continues as West Virginia Route 55, east to U.S. Route 29 in Gainesville. West of its interchange with Interstate 81 (I-81) in Strasburg, SR 55 runs concurrently with the easternmost portion of US 48 as part of Corridor H. East of Front Royal, the state highway serves as the local complement of I-66 as it passes through the towns of Marshall, The Plains, and Haymarket.
State Route 20 is a primary state highway in the U.S. state of Virginia. The state highway runs 89.79 miles (144.50 km) from U.S. Route 15 in Dillwyn north to SR 3 in Wilderness. SR 20 is a C-shaped route that connects Charlottesville with Farmville in Southside Virginia. The state highway also links Charlottesville to Fredericksburg by way of Orange County, within which SR 20 is the main east–west highway and intersects US 15 again in the county seat of Orange.
U.S. Route 33 is a part of the U.S. Highway System that runs from Elkhart, Indiana to Richmond, Virginia. In Virginia, the U.S. Highway runs 135.60 miles (218.23 km) from the West Virginia state line near Rawley Springs east to its eastern terminus at SR 33 in Richmond. US 33 is the primary east–west highway of Rockingham County, which lies in the Shenandoah Valley. The highway connects the independent city of Harrisonburg, the town of Elkton, and an entrance to Shenandoah National Park. East of the Blue Ridge Mountains, US 33 connects the Piedmont communities of Stanardsville, Gordonsville, and Louisa. The U.S. Highway is a major suburban and urban route in the Richmond metropolitan area. Within Richmond, US 33 runs concurrently with US 250. SR 33 continues from US 33's eastern terminus as a state-numbered extension of the U.S. Highway that connects Richmond with Virginia's Middle Peninsula.
Pennsylvania Route 68 is a 90.036-mile-long (144.899 km) east–west state highway located in western Pennsylvania in the United States. The western terminus of the route is at the Ohio state line west of Glasgow, where PA 68 continues into Ohio as State Route 39. The eastern terminus is at U.S. Route 322 in Clarion. The route runs southwest-northeast across Beaver, Butler, Armstrong, and Clarion counties. PA 68 follows the Ohio River between the Ohio border and Beaver, where it crosses the Beaver River into Rochester and heads northeast away from the Ohio River. The route runs through rural areas to Butler County, where it intersects Interstate 79 (I-79) in Zelienople before serving Evans City and Butler. PA 68 passes through a section of Armstrong County before crossing the Allegheny River into Clarion County. Here, the route passes through Rimersburg and Sligo before it has an interchange with I-80 and continues to its terminus in Clarion.
Interstate 81 (I-81) in the US state of West Virginia crosses the Eastern Panhandle region, linking Virginia to Maryland. The Interstate Highway, completed in 1966, spans 26 miles (42 km) through Berkeley County, paralleling U.S. Route 11 (US 11) for its entire length. I-81 enters the state near Ridgeway, travels northeast, bypassing the city of Martinsburg, and leaves the state at the Potomac River, which serves as the state line. The first solicitations for the construction of I-81 were published in 1959, with the first six miles (9.7 km) of freeway being opened in 1963, and the full length was completed by 1966. On average, between 45,000 and 60,000 vehicles use the freeway through the panhandle per day.
U.S. Route 40 in the U.S. state of Maryland runs from Garrett County in Western Maryland to Cecil County in the state's northeastern corner. With a total length of 221 miles (356 km), it is the longest numbered highway in Maryland. Almost half of the road overlaps or parallels with Interstate 68 (I-68) or I-70, while the old alignment is generally known as US 40 Alternate, US 40 Scenic, or Maryland Route 144. West of Baltimore, in the Piedmont and Appalachian Mountains / Blue Ridge region of the Western Maryland panhandle of the small state, the portions where it does not overlap an Interstate highway are mostly two-lane roads. The portion northeast of Baltimore going toward Wilmington in northern Delaware and Philadelphia in southeastern Pennsylvania is a four-lane divided highway, known as the Pulaski Highway. This section crosses the Susquehanna River at the north end of the Chesapeake Bay on the Thomas J. Hatem Memorial Bridge.
U.S. Route 250 is a part of the U.S. Highway System that runs from Sandusky, Ohio to Richmond, Virginia. In Virginia, the highway runs 166.74 miles (268.34 km) from the West Virginia state line near Hightown east to its eastern terminus at US 360 in Richmond. US 250 is the main east–west highway of Highland County, which is known as Virginia's Little Switzerland; the highway follows the path of the 19th century Staunton and Parkersburg Turnpike. From Staunton east to Richmond, the highway serves as the local complement to Interstate 64 (I-64), roughly following the 18th century Three Notch'd Road through Waynesboro and Charlottesville on its way through the Shenandoah Valley, its crossing of the Blue Ridge Mountains at Rockfish Gap, and the Piedmont. In the Richmond metropolitan area, US 250 is known as Broad Street, a major thoroughfare through the city's West End and downtown areas.
Pennsylvania Route 136 is a 40-mile-long (64 km) state highway located in Washington, Allegheny, and Westmoreland counties in Pennsylvania. The western terminus is at US 40 and PA 18 in Washington. The eastern terminus is at US 30 in Greensburg.
Pennsylvania Route 851 is a 32.6-mile-long (52.5 km) state highway located in York County, Pennsylvania. The western terminus is located at PA 516 in the Codorus Township community of Sticks. The eastern terminus is located at PA 74 in Peach Bottom Township.
U.S. Route 11 (US 11) in the U.S. state of West Virginia spans 26.2 miles (42.2 km) across the Eastern Panhandle region. US 11 enters the state near Ridgeway and crosses into Maryland just south of Williamsport. The highway closely parallels Interstate 81 (I-81) for its entire length.
Washington Heritage Trail 
WV 45 near Gerrardstown 
US 340 / WV 9 in Charles Town
