XAGE1D

XAGE1B
Identifiers
Aliases	XAGE1B , CT12.1, CT12.1C, CT12.1D, CT12.1E, CTP9, GAGED2, XAGE-1, XAGE1, XAGE1C, XAGE1D, X antigen family member 1E, X antigen family member 1B, XAGE1E, CT12.1b
External IDs	OMIM: 300289, 300744, 300745; HomoloGene: 135786; GeneCards: XAGE1B; OMA:XAGE1B - orthologs
Gene location (Human) Chr. X chromosome (human) [1] Band Xp11.22 Start 52,512,077 bp [1] End 52,520,803 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad right testis left testis upper lobe of left lung tonsil monocyte right lung apex of heart lymph node n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 653067 n/a Ensembl ENSG00000204382 n/a UniProt Q9HD64 n/a RefSeq (mRNA) NM_001097597 NM_001097598 NM_001097602 NM_001097603 NM_001097604 NM_001097605 NM_020411 NM_133430 NM_133431 n/a RefSeq (protein) NP_001091073 NP_001091074 NP_065144 n/a Location (UCSC) Chr X: 52.51 – 52.52 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

G antigen family D member 2 is a protein that in humans is encoded by the XAGE1D gene. ^[3]

This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene generates 3 transcript variants, and one of which includes 2 transcripts generated from alternate transcription initiation sites. ^[3]

References

1. GRCh38: Ensembl release 89: ENSG00000204382 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: XAGE1 X antigen family, member 1".^{[ dead link ]}

Further reading

• Brinkmann U, Vasmatzis G, Lee B, Pastan I (April 1999). "Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database". Cancer Research. 59 (7): 1445–8. PMID   10197611.
• Liu XF, Helman LJ, Yeung C, Bera TK, Lee B, Pastan I (September 2000). "XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma". Cancer Research. 60 (17): 4752–5. PMID   10987281.
• Zendman AJ, van Kraats AA, den Hollander AI, Weidle UH, Ruiter DJ, van Muijen GN (January 2002). "Characterization of XAGE-1b, a short major transcript of cancer/testis-associated gene XAGE-1, induced in melanoma metastasis". International Journal of Cancer. 97 (2): 195–204. doi:10.1002/ijc.1584. PMID   11774264. S2CID   36598913.
• Zendman AJ, Van Kraats AA, Weidle UH, Ruiter DJ, Van Muijen GN (May 2002). "The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma". International Journal of Cancer. 99 (3): 361–9. doi: 10.1002/ijc.10371 . PMID   11992404. S2CID   45958151.
• Egland KA, Kumar V, Duray P, Pastan I (May 2002). "Characterization of overlapping XAGE-1 transcripts encoding a cancer testis antigen expressed in lung, breast, and other types of cancers". Molecular Cancer Therapeutics. 1 (7): 441–50. PMID   12479262.
• Lim JH, Kim SP, Gabrielson E, Park YB, Park JW, Kwon TK (August 2005). "Activation of human cancer/testis antigen gene, XAGE-1, in tumor cells is correlated with CpG island hypomethylation". International Journal of Cancer. 116 (2): 200–6. doi:10.1002/ijc.21007. PMID   15800911. S2CID   25575235.
• Nakagawa K, Noguchi Y, Uenaka A, Sato S, Okumura H, Tanaka M, et al. (August 2005). "XAGE-1 expression in non-small cell lung cancer and antibody response in patients". Clinical Cancer Research. 11 (15): 5496–503. doi:10.1158/1078-0432.CCR-05-0216. PMID   16061866. S2CID   8514961.
• Sato S, Noguchi Y, Ohara N, Uenaka A, Shimono M, Nakagawa K, et al. (March 2007). "Identification of XAGE-1 isoforms: predominant expression of XAGE-1b in testis and tumors". Cancer Immunity. 7: 5. PMC   2935747 . PMID   17335148.