YAF2

Last updated
YAF2
Protein YAF2 PDB 2d9g.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases YAF2 , YY1 associated factor 2
External IDs OMIM: 607534 HomoloGene: 136401 GeneCards: YAF2
Orthologs
SpeciesHumanMouse
Entrez

10138

n/a

Ensembl

ENSG00000015153

n/a

UniProt

Q8IY57

n/a

RefSeq (mRNA)

n/a

RefSeq (protein)

NP_001177906
NP_001177908
NP_001177909
NP_001307009
NP_005739

Contents

n/a

Location (UCSC) Chr 12: 42.16 – 42.24 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

YY1-associated factor 2 is a protein that in humans is encoded by the YAF2 gene. [3] [4]

The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1. [4]

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000015153 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ↑ Kalenik JL, Chen D, Bradley ME, Chen SJ, Lee TC (Mar 1997). "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1". Nucleic Acids Res. 25 (4): 843–9. doi:10.1093/nar/25.4.843. PMC   146511 . PMID   9016636.
  4. 1 2 "Entrez Gene: YAF2 YY1 associated factor 2".

Further reading


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