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Nasdaq: YTEN | |
Headquarters | Woburn, MA , USA |
Key people | Anthony J. Sinskey (Co-Founder), Oliver P. Peoples (CEO), Kristi Snell (CSO) |
Website | www |
Yield10 Bioscience (formerly Metabolix, Inc.) is a company developing new technologies to achieve improvements in crop yield to enhance global food security.
Founded in 1992, with the help of a licensing agreement with Massachusetts Institute of Technology (MIT), [1] Metabolix, Inc. is a bioscience company with headquarters in Cambridge, Massachusetts. Metabolix provides sustainable solutions to the plastic, chemical and energy industries. Oliver Peoples, Ph.D., and Anthony Sinskey, Ph.D., co-founded Metabolix after work at the (MIT) that identified the elementary methods and means for engineering polyhydroxyalkanoates production in plants and bacteria, thus making them biodegradable. [2]
In early 2017, Metabolix became Yield10 Bioscience, its crop research program. [3]
The centerpiece of the Metabolix's plant technology is polyhydroxybutyrate (PHB), the simplest member of the broad polyhydroxyalkanoate (PHA) family of biopolymers. They have worked with switchgrass, camelina, sugarcane, as well as tobacco. [4]
In 2009, Metabolix completed a field trial producing PHA in a tobacco crop. [5]
In 2012, Metabolix secured an ARPA-E grant to improve productivity of biofuel production in plants, specifically camelina. [6]
In 2011, Metabolix was awarded a $6.0 million grant to produce PHB in switchgrass and to develop methods to thermally convert the PHB-containing switchgrass to crotonic acid and a higher density residual biomass fraction for production of biofuel. [7]
In 2017, Yield10 participated in a Department of Energy program to help boost Camelina oilseed. [8]
C3 is the most common form of photosynthesis, existing in most crops suitable for human consumption, including wheat, canola, soybean and rice. In 2019 Yield10 announced results from its 2018 field test, claiming that its C3003 gene trait showed an 11% increase in seed yield among canola crops, when compared to control plants. Similarly, C3003 met its objectives for soybean yield, and showed an increase in Camelina. [9]
C4 photosynthesis plants, like corn and sugar cane, possess a more complex system of metabolic pathways. [10] In 2018, Yield reported promising results for its C3004 gene trait in Camelina lines, following growth chamber studies. [11]
Yield10 has also commenced development of CRISPR-enabled technology to impact crop yield. The company received a nonregulated status letter from the USDA-APHIS Biotechnology Regulatory Services (BRS) acknowledging that its camelina line has had a gene disrupted using CRISPR/Cas9 gene editing technology, resulting in the desired phenotype.
In 2019, Yield10 filed a U.S. Patent application for new technology enabling low-cost production of PHA-based biomaterials, knowing for their use in water treatment to remove nitrogen and phosphates, to maintain the viability and vigor of Camelina seed. [12]
In 2018, Yield10 was granted a non-exclusive research license to CRISPR-Cas9 gene editing technology by DowDuPont’s agricultural business, Corteva Agriscience, and the non-profit Broad Institute of MIT and Harvard. [13] The Company also has established a partnership with University of Missouri, exercising an option with the University to obtain exclusive worldwide licenses to advanced technologies for oilseed crops. [14] [15] The relationship expanded in 2019 to include a new gene target. [16] In 2018, Yield10 was granted a non-exclusive research license to Forage Genetics International, LLC, a subsidiary of Land O’Lakes, Inc., to conduct research with the novel traits within its forage sorghum development program as a strategy to improve biomass yields. [17]
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(help)Genetically modified foods, also known as genetically engineered foods, or bioengineered foods are foods produced from organisms that have had changes introduced into their DNA using the methods of genetic engineering. Genetic engineering techniques allow for the introduction of new traits as well as greater control over traits when compared to previous methods, such as selective breeding and mutation breeding.
Rapeseed, also known as rape, or oilseed rape, is a bright-yellow flowering member of the family Brassicaceae, cultivated mainly for its oil-rich seed, which naturally contains appreciable amounts of erucic acid. Canola are a group of rapeseed cultivars which were bred to have very low levels of erucic acid and are especially prized for use for human and animal food. Rapeseed is the third-largest source of vegetable oil and the second-largest source of protein meal in the world.
Panicum virgatum, commonly known as switchgrass, is a perennial warm season bunchgrass native to North America, where it occurs naturally from 55°N latitude in Canada southwards into the United States and Mexico. Switchgrass is one of the dominant species of the central North American tallgrass prairie and can be found in remnant prairies, in native grass pastures, and naturalized along roadsides. It is used primarily for soil conservation, forage production, game cover, as an ornamental grass, in phytoremediation projects, fiber, electricity, heat production, for biosequestration of atmospheric carbon dioxide, and more recently as a biomass crop for ethanol and butanol.
A designer baby is a baby whose genetic makeup has been selected or altered, often to include a particular gene or to remove genes associated with disease. This process usually involves analysing a wide range of human embryos to identify genes associated with particular diseases and characteristics, and selecting embryos that have the desired genetic makeup; a process known as preimplantation genetic diagnosis. Other potential methods by which a baby's genetic information can be altered involve directly editing the genome before birth. This process is not routinely performed and only one instance of this is known to have occurred as of 2019, where Chinese twins Lulu and Nana were edited as embryos, causing widespread criticism.
Camelina sativa is a flowering plant in the family Brassicaceae and is usually known in English as camelina, gold-of-pleasure, or false flax, also occasionally wild flax, linseed dodder, German sesame, and Siberian oilseed. It is native to Europe and to Central Asian areas. This plant is cultivated as an oilseed crop mainly in Europe and in North America.
Polyhydroxyalkanoates or PHAs are polyesters produced in nature by numerous microorganisms, including through bacterial fermentation of sugars or lipids. When produced by bacteria they serve as both a source of energy and as a carbon store. More than 150 different monomers can be combined within this family to give materials with extremely different properties. These plastics are biodegradable and are used in the production of bioplastics.
Genetically modified crops are plants used in agriculture, the DNA of which has been modified using genetic engineering methods. Plant genomes can be engineered by physical methods or by use of Agrobacterium for the delivery of sequences hosted in T-DNA binary vectors. In most cases, the aim is to introduce a new trait to the plant which does not occur naturally in the species. Examples in food crops include resistance to certain pests, diseases, environmental conditions, reduction of spoilage, resistance to chemical treatments, or improving the nutrient profile of the crop. Examples in non-food crops include production of pharmaceutical agents, biofuels, and other industrially useful goods, as well as for bioremediation.
Bioplastics are plastic materials produced from renewable biomass sources, such as vegetable fats and oils, corn starch, straw, woodchips, sawdust, recycled food waste, etc. Some bioplastics are obtained by processing directly from natural biopolymers including polysaccharides and proteins, while others are chemically synthesised from sugar derivatives and lipids from either plants or animals, or biologically generated by fermentation of sugars or lipids. In contrast, common plastics, such as fossil-fuel plastics are derived from petroleum or natural gas.
Pioneer Hi-Bred International, Inc. is a U.S.-based producer of seeds for agriculture. They are a major producer of genetically modified organisms (GMOs), including genetically modified crops with insect and herbicide resistance.
Biodegradable plastics are plastics that can be decomposed by the action of living organisms, usually microbes, into water, carbon dioxide, and biomass. Biodegradable plastics are commonly produced with renewable raw materials, micro-organisms, petrochemicals, or combinations of all three.
Thlaspi arvense, known by the common name field pennycress, is a flowering plant in the cabbage family Brassicaceae. It is native to Eurasia, and is a common weed throughout much of North America and its home.
Leptosphaeria maculans is a fungal pathogen of the phylum Ascomycota that is the causal agent of blackleg disease on Brassica crops. Its genome has been sequenced, and L. maculans is a well-studied model phytopathogenic fungus. Symptoms of blackleg generally include basal stem cankers, small grey lesions on leaves, and root rot. The major yield loss is due to stem canker. The fungus is dispersed by the wind as ascospores or rain splash in the case of the conidia. L. maculans grows best in wet conditions and a temperature range of 5–20 degrees Celsius. Rotation of crops, removal of stubble, application of fungicide, and crop resistance are all used to manage blackleg. The fungus is an important pathogen of Brassica napus (canola) crops.
Drought tolerance is the ability to which a plant maintains its biomass production during arid or drought conditions. Some plants are naturally adapted to dry conditions, surviving with protection mechanisms such as desiccation tolerance, detoxification, or repair of xylem embolism. Other plants, specifically crops like corn, wheat, and rice, have become increasingly tolerant to drought with new varieties created via genetic engineering.
Brassica carinata is a species of flowering plant in the Brassicaceae family. It is referred to by the common names Ethiopian rape, Ethiopian mustard. It is believed to be a hybrid between Brassica nigra and Brassica oleracea.
Jennifer Anne Doudna is an American biochemist who has done pioneering work in CRISPR gene editing, and made other fundamental contributions in biochemistry and genetics. She received the 2020 Nobel Prize in Chemistry, with Emmanuelle Charpentier, "for the development of a method for genome editing." She is the Li Ka Shing Chancellor's Chair Professor in the Department of Chemistry and the Department of Molecular and Cell Biology at the University of California, Berkeley. She has been an investigator with the Howard Hughes Medical Institute since 1997.
Ceres, Inc. was a biotechnology company based in Thousand Oaks, California, United States that operated from 1996 to 2016, when it was acquired by Land O'Lakes. The company was a spinoff from UCLA researchers. Its ultimate commercial products were seeds of genetically modified crops used for biofuel production. In addition to its operations in the United States, Ceres had a subsidiary in Brazil called Ceres Sementes do Brasil.
Danimer Scientific, formerly known as Meredian Holdings Group Inc. and MHG, is a biopolymer manufacturer headquartered in Bainbridge, Georgia.
Barbara Jane Howlett is an Australian fungal plant pathologist.
Zachary B. Lippman is an American plant biologist and the Jacob Goldfield Professor of Genetics at Cold Spring Harbor Laboratory and a member of the National Academy of Sciences Lippman has used gene editing technology to investigate the control of fruit production in various crops. In 2019 he was awarded a MacArthur Fellowship and in 2020 he received the National Academy of Sciences Prize in Food and Agriculture Sciences.
Isobel Parkin Ph.D. is a Canadian research scientist with Agriculture and Agri-Food Canada. She is one of the world's premier canola scientists and her area of expertise focuses on brassica genomics, comparative genome organization, global gene expression analysis, and abiotic stress responses. She is well known for her work on an international project on the genetics of oil seeds, in particular the mapping and sequencing of the canola oil genome. She Co-lead the Canadian Canola Genome Sequence (CanSeq) team that successfully deciphered the canola genome and developed a high-quality genome sequence.
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