Z583

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Z583
Z583 structure.png
Identifiers
  • N-[3-[[6-[[1-(2-methoxyethyl)pyrazol-4-yl]amino]pyrazolo[3,4-d]pyrimidin-1-yl]methyl]phenyl]prop-2-enamide
CAS Number
PubChem CID
Chemical and physical data
Formula C21H22N8O2
Molar mass 418.461 g·mol−1
3D model (JSmol)
  • COCCN1C=C(C=N1)NC2=NC=C3C=NN(C3=N2)CC4=CC(=CC=C4)NC(=O)C=C
  • InChI=1S/C21H22N8O2/c1-3-19(30)25-17-6-4-5-15(9-17)13-29-20-16(11-24-29)10-22-21(27-20)26-18-12-23-28(14-18)7-8-31-2/h3-6,9-12,14H,1,7-8,13H2,2H3,(H,25,30)(H,22,26,27)
  • Key:BOBFKXIKGHTPJB-UHFFFAOYSA-N

Z583 (GLXC-26150) is a chemical compound which acts as a potent and highly selective inhibitor of JAK3, and was developed for the treatment of rheumatoid arthritis. [1] [2] [3] [4] [5]

See also

Related Research Articles

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References

  1. Baillache DJ, Unciti-Broceta A (October 2020). "Recent developments in anticancer kinase inhibitors based on the pyrazolo[3,4-d]pyrimidine scaffold". RSC Medicinal Chemistry. 11 (10): 1112–1135. doi:10.1039/d0md00227e. PMC   7652001 . PMID   33479617.
  2. Chen C, Yin Y, Shi G, Zhou Y, Shao S, Wei Y, et al. (August 2022). "A highly selective JAK3 inhibitor is developed for treating rheumatoid arthritis by suppressing γc cytokine-related JAK-STAT signal". Science Advances. 8 (33): eabo4363. Bibcode:2022SciA....8O4363C. doi:10.1126/sciadv.abo4363. PMC   9390995 . PMID   35984890.
  3. Phillips R (October 2022). "Novel JAK3-specific inhibitor safe and effective in mouse RA model". Nature Reviews. Rheumatology. 18 (10): 551. doi:10.1038/s41584-022-00839-8. PMID   36071217.
  4. Xue C, Yao Q, Gu X, Shi Q, Yuan X, Chu Q, et al. (May 2023). "Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer". Signal Transduction and Targeted Therapy. 8 (1): 204. doi:10.1038/s41392-023-01468-7. PMC   10196327 . PMID   37208335.
  5. Jensen LT, Attfield KE, Feldmann M, Fugger L (November 2023). "Allosteric TYK2 inhibition: redefining autoimmune disease therapy beyond JAK1-3 inhibitors". eBioMedicine. 97: 104840. doi:10.1016/j.ebiom.2023.104840. PMC   10589750 . PMID   37863021.