| ZDHHC17 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | ZDHHC17 , HIP14, HIP3, HYPH, HSPC294, zinc finger DHHC-type containing 17, DHHC-17, zinc finger DHHC-type palmitoyltransferase 17, DHHC17 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 607799 MGI: 2445110 HomoloGene: 56324 GeneCards: ZDHHC17 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Palmitoyltransferase ZDHHC17 is an enzyme that contains a DHHC domain that in humans is encoded by the ZDHHC17 gene. [5] [6] [7]
ZDHHC17 has been shown to interact with Huntingtin. [8] [9]
Huntingtin(Htt) is the protein coded for in humans by the HTT gene, also known as the IT15 ("interesting transcript 15") gene. Mutated HTT is the cause of Huntington's disease (HD), and has been investigated for this role and also for its involvement in long-term memory storage.
Huntingtin-interacting protein 1 also known as HIP-1 is a protein that in humans is encoded by the HIP1 gene.
Atrophin-1 is a protein that in humans is encoded by the ATN1 gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. The function of Atrophin-1 has not yet been determined. There is evidence provided by studies of Atrophin-1 in animals to suggest it acts as a transcriptional co-repressor. Atrophin-1 can be found in the nuclear and cytoplasmic compartments of neurons. It is expressed in nervous tissue.
Optineurin is a protein that in humans is encoded by the OPTN gene.
AP-2 complex subunit alpha-2 is a protein that in humans is encoded by the AP2A2 gene.
Alsin is a protein that in humans is encoded by the ALS2 gene. ALS2 orthologs have been identified in all mammals for which complete genome data are available.
Pre-mRNA-processing factor 40 homolog A is a protein that in humans is encoded by the PRPF40A gene.
Endophilin-A3 is a protein that in humans is encoded by the SH3GL3 gene.
Symplekin is a protein that in humans is encoded by the SYMPK gene.
Ubiquitin-conjugating enzyme E2 K is a protein that in humans is encoded by the UBE2K gene.
SET domain containing 2 is an enzyme that in humans is encoded by the SETD2 gene.
Trafficking kinesin-binding protein 2 is a protein that in humans is encoded by the TRAK2 gene.
Huntingtin-interacting protein 1-related protein is a protein that in humans is encoded by the HIP1R gene.
ZDHHC8 is a putative palmitoyltransferase enzyme containing a DHHC domain that in humans is encoded by the ZDHHC8 gene.
Small EDRK-rich factor 2 is a protein that in humans is encoded by the SERF2 gene.
Intraflagellar transport protein 57 homolog is a protein that in humans is encoded by the IFT57 gene.
Probable palmitoyltransferase ZDHHC4 is an enzyme that in humans is encoded by the ZDHHC4 gene.
Palmitoyltransferase ZDHHC3 is an enzyme that in humans is encoded by the ZDHHC3 gene that contains a DHHC domain.
In molecular biology the DHHC domain is a protein domain that acts as an enzyme, which adds a palmitoyl chemical group to proteins in order to anchor them to cell membranes. The DHHC domain was discovered in 1999 and named after a conserved sequence motif found in its protein sequence. Roth and colleagues showed that the yeast Akr1p protein could palmitoylate Yck2p in vitro and inferred that the DHHC domain defined a large family of palmitoyltransferases. In mammals twenty three members of this family have been identified and their substrate specificities investigated. Some members of the family such as ZDHHC3 and ZDHHC7 enhance palmitoylation of proteins such as PSD-95, SNAP-25, GAP43, Gαs. Others such as ZDHHC9 showed specificity only toward the H-Ras protein. However, a recent study questions the involvement of classical enzyme-substrate recognition and specificity in the palmitoylation reaction. Several members of the family have been implicated in human diseases.
Pre-mRNA-processing factor 40 homolog B is a protein that in humans that is encoded by the PRPF40B gene.
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