ZDHHC8

ZDHHC8
Identifiers
Aliases	ZDHHC8 , DHHC8, ZDHHCL1, ZNF378, zinc finger DHHC-type containing 8, zinc finger DHHC-type palmitoyltransferase 8
External IDs	OMIM: 608784 MGI: 1338012 HomoloGene: 8363 GeneCards: ZDHHC8
Gene location (Human)
Chr.	Chromosome 22 (human)
End	20,148,007 bp
RNA expression pattern
	Top expressed in
	tibial nerve; ; stromal cell of endometrium; ; anterior pituitary; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; body of pancreas; ; canal of the cervix; ; right adrenal gland; ; right lung; ; gastric mucosa;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	palmitoyltransferase activity ; transferase activity ; acyltransferase activity ; protein-cysteine S-palmitoyltransferase activity ;
Cellular component	integral component of membrane ; Golgi apparatus ; cytoplasmic vesicle membrane ; mitochondrion ; membrane ; cytoplasmic vesicle ; cytosol ;
Biological process	protein palmitoylation ; locomotory behavior ; high-density lipoprotein particle assembly ;
	Sources:Amigo / QuickGO
Orthologs
	29801
	27801
	ENSG00000099904
	ENSMUSG00000060166
	Q9ULC8
	Q5Y5T5
	NM_001185024 ; NM_013373
	NM_172151
	NP_001171953 ; NP_037505
	NP_742163 ; NP_001365948
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 27, 2023

ZDHHC8 is a putative palmitoyltransferase enzyme containing a DHHC domain that in humans is encoded by the ZDHHC8 gene.^[4]^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000099904 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (Jan 2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi: 10.1093/dnares/6.5.337 . PMID 10574462.
↑ Mukai J, Liu H, Burt RA, Swor DE, Lai WS, Karayiorgou M, Gogos JA (Jun 2004). "Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia". Nat Genet. 36 (7): 725–31. doi: 10.1038/ng1375 . PMID 15184899.
↑ "Entrez Gene: ZDHHC8 zinc finger, DHHC-type containing 8".

Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID 10591208.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi: 10.1186/gb-2004-5-10-r84 . PMC 545604 . PMID 15461802.
Chen WY, Shi YY, Zheng YL, et al. (2005). "Case-control study and transmission disequilibrium test provide consistent evidence for association between schizophrenia and genetic variation in the 22q11 gene ZDHHC8". Hum. Mol. Genet. 13 (23): 2991–5. doi: 10.1093/hmg/ddh322 . PMID 15489219.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Saito S, Ikeda M, Iwata N, et al. (2005). "No association was found between a functional SNP in ZDHHC8 and schizophrenia in a Japanese case-control population". Neurosci. Lett. 374 (1): 21–4. doi:10.1016/j.neulet.2004.10.015. PMID 15631889. S2CID 24312967.
Glaser B, Schumacher J, Williams HJ, et al. (2005). "No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples". Biol. Psychiatry. 58 (1): 78–80. doi:10.1016/j.biopsych.2005.03.017. PMID 15992527. S2CID 20264569.
Otani K, Ujike H, Tanaka Y, et al. (2006). "The ZDHHC8 gene did not associate with bipolar disorder or schizophrenia". Neurosci. Lett. 390 (3): 166–70. doi:10.1016/j.neulet.2005.08.019. PMID 16150541. S2CID 26919027.
Demily C, Legallic S, Bou J, et al. (2007). "ZDHHC8 single nucleotide polymorphism rs175174 is not associated with psychiatric features of the 22q11 deletion syndrome or schizophrenia". Psychiatr. Genet. 17 (5): 311–2. doi:10.1097/YPG.0b013e328133f369. PMID 17728672.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000099904 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10574462-4] Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (Jan 2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi: 10.1093/dnares/6.5.337 . PMID 10574462.

[pmid15184899-5] Mukai J, Liu H, Burt RA, Swor DE, Lai WS, Karayiorgou M, Gogos JA (Jun 2004). "Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia". Nat Genet. 36 (7): 725–31. doi: 10.1038/ng1375 . PMID 15184899.

[entrez-6] "Entrez Gene: ZDHHC8 zinc finger, DHHC-type containing 8".

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ZDHHC8

Related Research Articles

References

Further reading