ZNF16

ZNF16
Identifiers
Aliases	ZNF16 , HZF1, KOX9, zinc finger protein 16
External IDs	OMIM: 601262; HomoloGene: 56008; GeneCards: ZNF16; OMA:ZNF16 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q24.3 Start 144,930,358 bp [1] End 144,950,888 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle oocyte ganglionic eminence gastrocnemius muscle muscle of thigh secondary oocyte ventricular zone skin of leg gingival epithelium n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding protein binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleolus Biological process positive regulation of cell cycle phase transition positive regulation of kinase activity cell cycle negative regulation of apoptotic process regulation of transcription, DNA-templated positive regulation of megakaryocyte differentiation positive regulation of cell division positive regulation of erythrocyte differentiation transcription, DNA-templated positive regulation of cell population proliferation cellular response to sodium dodecyl sulfate cell division regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7564 n/a Ensembl ENSG00000170631 n/a UniProt P17020 n/a RefSeq (mRNA) NM_001029976 NM_006958 n/a RefSeq (protein) NP_001025147 NP_008889 n/a Location (UCSC) Chr 8: 144.93 – 144.95 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Zinc finger protein 16 is a protein that in humans is encoded by the ZNF16 gene. ^[3]

The protein encoded by this gene contains a C2H2 type of zinc finger, and thus may function as a transcription factor. This gene is located in a region close to ZNF7/KOX4, a gene also encoding a zinc finger protein, on chromosome 8. Two alternatively spliced variants, encoding the same protein, have been identified. ^[3]

References

1. GRCh38: Ensembl release 89: ENSG00000170631 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: ZNF16 zinc finger protein 16".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Dreier B, Segal DJ, Barbas CF (2000). "Insights into the molecular recognition of the 5'-GNN-3' family of DNA sequences by zinc finger domains". J. Mol. Biol. 303 (4): 489–502. doi:10.1006/jmbi.2000.4133. PMID   11054286.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Rousseau-Merck MF, Duro D, Berger R, Thiesen HJ (1995). "Chromosomal localization of two KOX zinc finger genes on chromosome bands 7q21-q22". Ann. Genet. 38 (2): 81–4. PMID   7486829.
• Thiesen HJ (1991). "Multiple genes encoding zinc finger domains are expressed in human T cells". New Biol. 2 (4): 363–74. PMID   2288909.