Zinc finger protein 197

ZNF197
Identifiers
Aliases	ZNF197 , D3S1363E, P18, VHLaK, ZKSCAN9, ZNF166, ZNF20, ZSCAN41, zinc finger protein 197
External IDs	OMIM: 618359 HomoloGene: 48487 GeneCards: ZNF197
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p21.31 Start 44,584,888 bp [1] End 44,648,471 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence Achilles tendon corpus callosum skeletal muscle tissue islet of Langerhans gastrocnemius muscle endometrium stromal cell of endometrium smooth muscle tissue sural nerve n/a More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding metal ion binding nucleic acid binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus intracellular anatomical structure Biological process transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10168 n/a Ensembl ENSG00000281709 ENSG00000186448 n/a UniProt O14709 n/a RefSeq (mRNA) NM_001024855 NM_001323293 NM_001323294 NM_001323295 NM_001323296 NM_006991 n/a RefSeq (protein) NP_001020026 NP_001310222 NP_001310223 NP_001310224 NP_001310225 NP_008922 n/a Location (UCSC) Chr 3: 44.58 – 44.65 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Zinc finger protein 197 is a protein that in humans is encoded by the ZNF197 gene. ^[3]

Function

This gene product belongs to the zinc finger protein superfamily, members of which are regulatory proteins characterized by nucleic acid-binding zinc finger domains. The encoded protein contains 20 tandemly arrayed C2H2-type zinc fingers, a Kruppel-associated box (KRAB) domain, and a SCAN box. This transcript turns over rapidly and contains 3' UTR AUUUA motifs, which are often a hallmark of rapid turnover. It is overexpressed in some thyroid papillary carcinomas. This gene is located in a cluster of zinc finger genes at 3p21. Naturally-occurring readthrough transcription is observed between this gene and the upstream zinc finger protein 660 gene and is represented by GeneID:110354863.

References

1. ENSG00000186448 GRCh38: Ensembl release 89: ENSG00000281709, ENSG00000186448 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: Zinc finger protein 197" . Retrieved 2017-07-06.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.