Zinc finger protein 674

ZNF674
Identifiers
Aliases	ZNF674 , MRX92, ZNF673B, zinc finger protein 674
External IDs	OMIM: 300573; HomoloGene: 87837; GeneCards: ZNF674; OMA:ZNF674 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	46,545,457 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; Achilles tendon; ; ganglionic eminence; ; epithelium of colon; ; ventricular zone; ; stromal cell of endometrium; ; muscle of thigh; ; islet of Langerhans; ; monocyte;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding ; metal ion binding ; nucleic acid binding ; DNA-binding transcription factor activity, RNA polymerase II-specific ;
Cellular component	intracellular anatomical structure ; nucleus ;
Biological process	regulation of transcription, DNA-templated ; transcription, DNA-templated ; regulation of transcription by RNA polymerase II ; negative regulation of transcription, DNA-templated ;
	Sources:Amigo / QuickGO
Orthologs
	641339
	n/a
	ENSG00000251192
	n/a
	Q2M3X9
	n/a
	NM_001039891 ; NM_001146291 ; NM_001190417
	n/a
	NP_001034980 ; NP_001139763 ; NP_001177346
	n/a
	Wikidata
View/Edit Human

Last updated October 01, 2025

Zinc finger protein 674 is a protein that in humans is encoded by the ZNF674 gene. ^[3]

Function

This gene encodes a zinc finger protein with an N-terminal Kruppel-associated box-containing (KRAB) domain and 11 Kruppel-type C2H2 zinc finger domains. Like other zinc finger proteins, this gene may function as a transcription factor. This gene resides on an area of chromosome X that has been implicated in nonsyndromic X-linked intellectual disability. Alternative splicing results in multiple transcript variants encoding different isoforms.

1 2 3 GRCh38: Ensembl release 89: ENSG00000251192 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Zinc finger protein 674" . Retrieved 2016-03-02.