CDH10

Last updated
CDH10
Identifiers
Aliases CDH10 , cadherin 10
External IDs OMIM: 604555 MGI: 107436 HomoloGene: 68530 GeneCards: CDH10
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001190450
NM_006727
NM_001317222
NM_001317224
NM_001362460

Contents

NM_009865
NM_001316758

RefSeq (protein)

NP_001304151
NP_001304153
NP_006718
NP_001349389
NP_001304153.1

NP_001303687
NP_033995

Location (UCSC) Chr 5: 24.49 – 24.64 Mb Chr 15: 18.82 – 19.01 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cadherin 10 is a protein that in humans is encoded by the CDH10 gene. [5] [6]

Clinical significance

An association with autism has been suggested. [7]

See also

Related Research Articles

T-cadherin

T-cadherin also known as cadherin 13, H-cadherin (heart) (CDH13) is a unique member of cadherin superfamily because it lacks the transmembrane and cytoplasmic domains and is anchored to the cells membrane through the GPI anchor. Classical cadherins are necessary for cell–cell contacts, dynamic regulation of morphogenetic processes in embryos and tissue integrity in adult organism. Cadherins function as membrane receptors mediating outside-in signals, activating small GTPases and beta-catenin/Wnt pathway, and resulting in dynamic cytoskeleton reorganization and changes in the phenotype.

CDH2

N-cadherin, also known as Cadherin-2 (CDH2) or neural cadherin (NCAD) is a protein that in humans is encoded by the CDH2 gene. CDH2 has also been designated as CD325. N-cadherin is a transmembrane protein expressed in multiple tissues and functions to mediate cell–cell adhesion. In cardiac muscle, N-cadherin is an integral component in adherens junctions residing at intercalated discs, which function to mechanically and electrically couple adjacent cardiomyocytes. Alterations in expression and integrity of N-cadherin protein has been observed in various forms of disease, including human dilated cardiomyopathy. Variants in CDH2 have also been identified to cause a syndromic neurodevelopmental disorder.

VE-cadherin

Cadherin 5, type 2 or VE-cadherin also known as CD144, is a type of cadherin. It is encoded by the human gene CDH5.

CELSR1 Protein-coding gene in humans

Cadherin EGF LAG seven-pass G-type receptor 1 also known as flamingo homolog 2 or cadherin family member 9 is a protein that in humans is encoded by the CELSR1 gene.

CDH3 (gene)

Cadherin-3, also known as P-Cadherin, is a protein that in humans is encoded by the CDH3 gene.

NRCAM

Neuronal cell adhesion molecule is a protein that in humans is encoded by the NRCAM gene.

JAM2

Junctional adhesion molecule B is a protein that in humans is encoded by the JAM2 gene. JAM2 has also been designated as CD322.

CDH11

Cadherin-11 is a protein that in humans is encoded by the CDH11 gene.

CDH4

Cadherin-4 is a protein that in humans is encoded by the CDH4 gene.

CDH6

Cadherin-6 is a protein that in humans is encoded by the CDH6 gene.

CDH15

Cadherin-15 is a protein that in humans is encoded by the CDH15 gene.

Protein DEPP

Protein DEPP also known as decidual protein induced by progesterone (DEPP) and fasting-induced gene protein (FIG) is a protein that in humans is encoded by the DEPP gene.

CDH16

Cadherin-16 is a protein that in humans is encoded by the CDH16 gene.

CDH17

Cadherin-17 is a protein that in humans is encoded by the CDH17 gene.

PCDH1

Protocadherin-1 is a protein that in humans is encoded by the PCDH1 gene.

CDH12

Cadherin-12 is a protein that in humans is encoded by the CDH12 gene.

ECD (gene)

Protein SGT1 is a protein that in humans is encoded by the ECD gene.

CDH8

Cadherin-8 is a protein that in humans is encoded by the CDH8 gene.

PCDH12

Protocadherin-12 is a protein that in humans is encoded by the PCDH12 gene.

CDH9

Cadherin 9 is a protein that in humans is encoded by the CDH9 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000040731 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022321 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: cadherin 10".
  6. Suzuki S, Sano K, Tanihara H (April 1991). "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue". Cell Regul. 2 (4): 261–70. doi:10.1091/mbc.2.4.261. PMC   361775 . PMID   2059658.
  7. Wang K, Zhang H, Ma D, et al. (May 2009). "Common genetic variants on 5p14.1 associate with autism spectrum disorders". Nature. 459 (7246): 528–33. doi:10.1038/nature07999. PMC   2943511 . PMID   19404256.

Further reading