CDH17

CDH17
Identifiers
Aliases	CDH17 , CDH16, HPT-1, HPT1, cadherin 17
External IDs	OMIM: 603017 MGI: 1095414 HomoloGene: 56859 GeneCards: CDH17
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q22.1 Start 94,127,162 bp [1] End 94,217,303 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 A1 Start 11,758,147 bp [2] End 11,817,895 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa rectum duodenum pancreatic ductal cell secondary oocyte appendix islet of Langerhans smooth muscle tissue gallbladder palpebral conjunctiva Top expressed in ileum intestinal villus left colon duodenum crypt of lieberkuhn of small intestine jejunum Paneth cell secondary oocyte sexually immature organism detrusor urinae muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding transporter activity metal ion binding integrin binding proton-dependent oligopeptide secondary active transmembrane transporter activity cytoskeletal protein binding protein homodimerization activity cadherin binding Cellular component integral component of membrane membrane cell surface plasma membrane basolateral plasma membrane nucleus cell junction catenin complex Biological process spleen development marginal zone B cell differentiation integrin-mediated signaling pathway positive regulation of integrin activation by cell surface receptor linked signal transduction germinal center B cell differentiation B cell differentiation adherens junction organization oligopeptide transport calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules oligopeptide transmembrane transport homophilic cell adhesion via plasma membrane adhesion molecules cell adhesion cell-cell junction assembly cell-cell adhesion mediated by cadherin cell-cell adhesion cell morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1015 12557 Ensembl ENSG00000079112 ENSMUSG00000028217 UniProt Q12864 Q9R100 RefSeq (mRNA) NM_001144663 NM_004063 NM_019753 RefSeq (protein) NP_001138135 NP_004054 NP_062727 Location (UCSC) Chr 8: 94.13 – 94.22 Mb Chr 4: 11.76 – 11.82 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cadherin-17 is a protein that in humans is encoded by the CDH17 gene. ^{[5] [6] [7]}

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000079112 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028217 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF (Aug 1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics. 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID   9615235.
6. Chalmers IJ, Hofler H, Atkinson MJ (Jun 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics. 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID   10191097.
7. "Entrez Gene: CDH17 cadherin 17, LI cadherin (liver-intestine)".

Further reading

• Gessner R, Tauber R (2001). "Intestinal cell adhesion molecules. Liver-intestine cadherin". Ann. N. Y. Acad. Sci. 915: 136–43. doi:10.1111/j.1749-6632.2000.tb05236.x. PMID   11193569. S2CID   27317315.
• Gilston A (1978). "Reducing the hazard of disconnected tubes". Anaesthesia. 32 (9): 922. doi: 10.1111/j.1365-2044.1977.tb10133.x . PMID   603017. S2CID   31703359.
• Dantzig AH, Hoskins JA, Tabas LB, et al. (1994). "Association of intestinal peptide transport with a protein related to the cadherin superfamily". Science. 264 (5157): 430–3. doi:10.1126/science.8153632. PMID   8153632.
• Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC   311086 . PMID   11337467.
• Grötzinger C, Kneifel J, Patschan D, et al. (2001). "LI-cadherin: a marker of gastric metaplasia and neoplasia". Gut. 49 (1): 73–81. doi:10.1136/gut.49.1.73. PMC   1728355 . PMID   11413113.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Takamura M, Sakamoto M, Ino Y, et al. (2003). "Expression of liver-intestine cadherin and its possible interaction with galectin-3 in ductal adenocarcinoma of the pancreas". Cancer Sci. 94 (5): 425–30. doi: 10.1111/j.1349-7006.2003.tb01459.x . PMID   12824888. S2CID   25229564.
• Wendeler MW, Praus M, Jung R, et al. (2004). "Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin". Exp. Cell Res. 294 (2): 345–55. doi:10.1016/j.yexcr.2003.11.022. PMID   15023525.
• Ko S, Chu KM, Luk JM, et al. (2004). "Overexpression of LI-cadherin in gastric cancer is associated with lymph node metastasis". Biochem. Biophys. Res. Commun. 319 (2): 562–8. doi:10.1016/j.bbrc.2004.04.197. PMID   15178443.
• Takamura M, Ichida T, Matsuda Y, et al. (2004). "Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma". Cancer Lett. 212 (2): 253–9. doi:10.1016/j.canlet.2004.03.016. PMID   15279905.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Wang XQ, Luk JM, Leung PP, et al. (2005). "Alternative mRNA splicing of liver intestine-cadherin in hepatocellular carcinoma". Clin. Cancer Res. 11 (2 Pt 1): 483–9. doi: 10.1158/1078-0432.483.11.2 . PMID   15701831.
• Wang XQ, Luk JM, Garcia-Barcelo M, et al. (2007). "Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma". Clin. Cancer Res. 12 (17): 5248–52. doi:10.1158/1078-0432.CCR-06-0558. PMID   16951245.

External links

• CDH17 human gene location in the UCSC Genome Browser .
• CDH17 human gene details in the UCSC Genome Browser .
• Human CDH16 genome location and CDH16 gene details page in the UCSC Genome Browser .