FOLFIRI

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FOLFIRI is a chemotherapy regimen for treatment of colorectal cancer. It is made up of the following drugs: [1]

Contents

Medical uses

FOLFIRI is used for colorectal cancer and gastric cancer. [2] FOLFIRI is effective in the treatment of metastatic colorectal cancer, but it has not been shown to be effective in the adjuvant therapy of colon and rectal cancer.

Regimen

The regimen consists of:

This cycle is typically repeated every two weeks. The dosages shown above may vary from cycle to cycle.

Combinations

FOLFIRI is often[ citation needed ] combined with bevacizumab, aflibercept, cetuximab or panitumumab to improve efficacy and response rate. [3]

Adverse effects

In the short term, irinotecan causes diarrhea, which may be acute or delayed in onset. Long term use[ citation needed ] of irinotecan may lead to neutropenia. [4]

See also

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References

  1. Chen, K; Gong, Y; Zhang, Q; Shen, Y; Zhou, T (2016). "Efficacy and safety of addition of bevacizumab to FOLFIRI or irinotecan/bolus 5-FU/LV (IFL) in patients with metastatic colorectal cancer: A meta-analysis". Medicine. 95 (46): e5221. doi:10.1097/MD.0000000000005221. PMC   5120901 . PMID   27861344.
  2. Tournigand, C; André, T; Achille, E; Lledo, G; Flesh, M; Mery-Mignard, D; Quinaux, E; Couteau, C; Buyse, M; Ganem, G; Landi, B; Colin, P; Louvet, C; de Gramont, A (Jan 15, 2004). "FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study". Journal of Clinical Oncology. 22 (2): 229–37. doi: 10.1200/jco.2004.05.113 . PMID   14657227.
  3. Kirstein, M. M.; Lange, A.; Prenzler, A.; Manns, M. P.; Kubicka, S.; Vogel, A. (2014). "Targeted Therapies in Metastatic Colorectal Cancer: A Systematic Review and Assessment of Currently Available Data". The Oncologist. 19 (11): 1156–68. doi:10.1634/theoncologist.2014-0032. PMC   4221380 . PMID   25326159.
  4. "Onivyde: EPAR – Product Information" (PDF). European Medicines Agency. 25 October 2016. Archived from the original (PDF) on 16 January 2017. Retrieved 14 January 2017.