Fenticonazole

Last updated
Fenticonazole
Fenticonazole.svg
Clinical data
Trade names Lomexin, Gynoxin
AHFS/Drugs.com International Drug Names
Routes of
administration
Topical (ovule, spray, cream)
ATC code
Legal status
Legal status
  • UK: POM (Prescription only)
  • US:Not approved
  • In general: ℞ (Prescription only)
Identifiers
  • 1-[2-(2,4-dichlorophenyl)-2-{[4-(phenylsulfanyl)phenyl]methoxy}ethyl]-1H-imidazole
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
CompTox Dashboard (EPA)
Chemical and physical data
Formula C24H20Cl2N2OS
Molar mass 455.40 g·mol−1
3D model (JSmol)
  • c1ccc(cc1)Sc2ccc(cc2)COC(Cn3ccnc3)c4ccc(cc4Cl)Cl
  • InChI=1S/C24H20Cl2N2OS/c25-19-8-11-22(23(26)14-19)24(15-28-13-12-27-17-28)29-16-18-6-9-21(10-7-18)30-20-4-2-1-3-5-20/h1-14,17,24H,15-16H2 X mark.svgN
  • Key:ZCJYUTQZBAIHBS-UHFFFAOYSA-N X mark.svgN
 X mark.svgNYes check.svgY  (what is this?)    (verify)

Fenticonazole is an imidazole antifungal drug, used locally as the nitrate in the treatment of vulvovaginal candidiasis. It is active against a range of organisms including dermatophyte pathogens, Malassezia furfur , and Candida albicans . Fenticonazole has also been shown to exhibit antibacterial action, with a spectrum of activity that includes bacteria commonly associated with superinfected fungal skin and vaginal infections, and antiparasitic action against the protozoan Trichomonas vaginalis. [1]

Contents

Uses and administration

A 200 mg pessary is inserted into the vagina at bedtime for 3 nights or a 600 mg pessary is inserted once only at bedtime. Fenticonazole Nitrate vaginal capsule is not greasy, does not soil and can easily be removed with water. [2] Fenticonazole nitrate is also applied topically as a 2% cream or solution for the treatment of fungal skin infections.[ citation needed ]

Pregnancy and lactation

Oral administration of Fenticonazole in rats has been reported to produce prolonged gestation and embryotoxic effects after doses above 40mg/kg/day. Fenticonazole does not interfere with the function of male and female gonads and does not modify the first phases of reproduction. Fenticonazole has shown no teratogenic effects in rats and rabbits. Fenticonazole or its metabolites cross the placental barrier in pregnant rats and rabbits after vaginal application and are excreted in milk of lactating rats. Since there is no experience of use during pregnancy or lactation, Fenticonazole Nitrate vaginal capsules should not be used unless the physician considers if essential to the welfare of the patient. [2]

Adverse effects

Burning and itching have been reported after the application of fenticonazole nitrate.[ citation needed ]

Intravaginal preparations of fenticonazole may damage latex contraceptives and additional contraceptive measures are therefore necessary during local administration.[ citation needed ]

Related Research Articles

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<span class="mw-page-title-main">Contraceptive vaginal ring</span>

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References

  1. Veraldi S, Milani R (2008). "Topical fenticonazole in dermatology and gynaecology: current role in therapy". Drugs. 68 (15): 2183–2194. doi:10.2165/00003495-200868150-00007. PMID   18840006. S2CID   46971075.
  2. 1 2 Stewart M (20 October 2020). Dajani S (ed.). "Fenticonazole for vaginal thrush". Patient. Egton Medical Information Systems Limited.

Further reading