The High Energy Transient Explorer was an American astronomical satellite with international participation. The prime objective of HETE was to carry out the first multiwavelength study of gamma-ray bursts with UV, X-ray, and gamma-ray instruments mounted on a single, compact spacecraft. A unique feature of the HETE mission was its capability to localize GRBs with ~10 arc second accuracy in near real time aboard the spacecraft, and to transmit these positions directly to a network of receivers at existing ground-based observatories enabling rapid, sensitive follow-up studies in the radio, IR, and optical bands. The satellite bus for the first HETE-1 was designed and built by AeroAstro, Inc. of Herndon, VA; the replacement satellite, HETE-2, was built by MIT based on the original HETE design.
Eicosanoids are signaling molecules made by the enzymatic or non-enzymatic oxidation of arachidonic acid or other polyunsaturated fatty acids (PUFAs) that are, similar to arachidonic acid, 20 carbon units in length. Eicosanoids are a sub-category of oxylipins, i.e. oxidized fatty acids of diverse carbon units in length, and are distinguished from other oxylipins by their overwhelming importance as cell signaling molecules. Eicosanoids function in diverse physiological systems and pathological processes such as: mounting or inhibiting inflammation, allergy, fever and other immune responses; regulating the abortion of pregnancy and normal childbirth; contributing to the perception of pain; regulating cell growth; controlling blood pressure; and modulating the regional flow of blood to tissues. In performing these roles, eicosanoids most often act as autocrine signaling agents to impact their cells of origin or as paracrine signaling agents to impact cells in the proximity of their cells of origin. Eicosanoids may also act as endocrine agents to control the function of distant cells.
Somogy is an administrative county in present Hungary, and also in the former Kingdom of Hungary.
RTL Klub is a Hungarian free-to-air television channel and it owned by RTL Group. It was one of Hungary's first commercial TV channels and began broadcasting only three days after its main rival TV2.
Szabolcs Balajcza is a Hungarian football goalkeeper who currently plays for Hetes Vikár.
Hosszúhetény is the most populous village in Baranya county, southwest Hungary, a significant centre of village tourism. It is located 18 kilometres northeast to Pécs, the county capital, in a valley between the feet of Zengő, the highest peak of the Mecsek mountains and the peak called Hármashegy.
Szenna is a village in Somogy county, Hungary. It is famous for the Szenna Open Air Museum, which won the Europa Nostra award in 1982.
ALOX12, also known as arachidonate 12-lipoxygenase, 12-lipoxygenase, 12S-Lipoxygenase, 12-LOX, and 12S-LOX is a lipoxygenase-type enzyme that in humans is encoded by the ALOX12 gene which is located along with other lipoyxgenases on chromosome 17p13.3. ALOX12 is 75 kilodalton protein composed of 663 amino acids.
G-protein coupled receptor 31 also known as 12-(S)-HETE receptor is a protein that in humans is encoded by the GPR31 gene. The human gene is located on chromosome 6q27 and encodes a G-protein coupled receptor protein composed of 319 amino acids.
5-Hydroxyeicosatetraenoic acid is an eicosanoid, i.e. a metabolite of arachidonic acid. It is produced by diverse cell types in humans and other animal species. These cells may then metabolize the formed 5(S)-HETE to 5-oxo-eicosatetraenoic acid (5-oxo-ETE), 5(S),15(S)-dihydroxyeicosatetraenoic acid, or 5-oxo-15-hydroxyeicosatetraenoic acid.
András Kern is a Hungarian actor, producer, writer, singer and comedian.
Trzcinno is a village in Gmina Miastko, Bytów County, Pomeranian Voivodeship, in northern Poland. It lies approximately 28 kilometres (17 mi) south-west of Bytów and 106 km (66 mi) south-west of Gdańsk.
Nowe Huty is a village in the administrative district of Gmina Tuchomie, within Bytów County, Pomeranian Voivodeship, in northern Poland. It lies approximately 4 kilometres (2 mi) west of Tuchomie, 15 km (9 mi) west of Bytów, and 93 km (58 mi) west of the regional capital Gdańsk.
Tivadar Farkasházy is a Hungarian humorist, author, and journalist.
12-Hydroxyeicosatetraenoic acid (12-HETE) is a derivative of the 20 carbon polyunsaturated fatty acid, arachidonic acid, containing a hydroxyl residue at carbon 12 and a 5Z,8Z,10E,14Z Cis–trans isomerism configuration in its four double bonds. It was first found as a product of arachidonic acid metabolism made by human and bovine platelets through their 12S-lipoxygenase enzyme(s). However, the term 12-HETE is ambiguous in that it has been used to indicate not only the initially detected "S" stereoisomer, 12S-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid, made by platelets, but also the later detected "R" stereoisomer, 12(R)-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid made by other tissues through their 12R-lipoxygenase enzyme, ALOX12B. The two isomers, either directly or after being further metabolized, have been suggested to be involved in a variety of human physiological and pathological reactions. Unlike hormones which are secreted by cells, travel in the circulation to alter the behavior of distant cells, and thereby act as Endocrine signalling agents, these arachidonic acid metabolites act locally as Autocrine signalling and/or Paracrine signaling agents to regulate the behavior of their cells of origin or of nearby cells, respectively. In these roles, they may amplify or dampen, expand or contract cellular and tissue responses to disturbances.
Henrik Havas is a Hungarian journalist who served as spokesman of the Hungarian government from 1 November 1995 to 7 November 1995.
RTLII is a Hungarian commercial television channel, owned by RTL Group. It is rivaling with Super TV2 and Viasat3. The channel launched on 1 October 2012.
15-Hydroxyeicosatetraenoic acid is an eicosanoid, i.e. a metabolite of arachidonic acid. Various cell types metabolize arachidonic acid to 15(S)-hydroperoxyeicosatetraenoic acid. This initial hydroperoxide product is extremely short-lived in cells: if not otherwise metabolized, it is rapidly reduced to 15(S)-HETE. Both of these metabolites, depending on the cell type which forms them, can be further metabolized to 15-oxo-eicosatetraenoic acid (15-oxo-ETE), 5S,15S-dihydroxy-eicosatetraenoic acid, 5-oxo-15(S)-hydroxyeicosatetraenoic acid (5-oxo-15 -HETE, a subset of specialized pro-resolving mediators viz., the lipoxins, a class of pro-inflammatory mediators, the eoxins, and other products that have less well-defined activities and functions. Thus, 15 -HETE and 15 -HpETE, in addition to having intrinsic biological activities, are key precursors to numerous biologically active derivatives.
20-Hydroxyeicosatetraenoic acid, also known as 20-HETE or 20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid, is an eicosanoid metabolite of arachidonic acid that has a wide range of effects on the vascular system including the regulation of vascular tone, blood flow to specific organs, sodium and fluid transport in the kidney, and vascular pathway remodeling. These vascular and kidney effects of 20-HETE have been shown to be responsible for regulating blood pressure and blood flow to specific organs in rodents; genetic and preclinical studies suggest that 20-HETE may similarly regulate blood pressure and contribute to the development of stroke and heart attacks. Additionally the loss of its production appears to be one cause of the human neurological disease, Hereditary spastic paraplegia. Preclinical studies also suggest that the overproduction of 20-HETE may contribute to the progression of certain human cancers, particularly those of the breast.
Kaposvár is a district in the central-eastern part of Somogy County. Kaposvár is also the name of the town where the district and county seat is found. The district is located in the Southern Transdanubia Statistical Region.
