| MUC2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | MUC2 , MLP, MUC-2, SMUC, mucin 2, oligomeric mucus/gel-forming | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 158370 MGI: 1339364 HomoloGene: 136755 GeneCards: MUC2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Mucin 2, oligomeric mucus gel-forming, also known as MUC2, is a protein that in humans is encoded by the MUC2 gene. [5] [6]
This gene encodes a member of the mucin protein family. The protein encoded by this gene, also called mucin 2, is secreted onto mucosal surfaces. [5]
Mucin 2 is particularly prominent in the gut where it is secreted from goblet cells in the epithelial lining into the lumen of the large intestine. There, mucin 2, along with small amounts of related-mucin proteins, polymerizes into a gel of which 80% by weight is oligosaccharide side-chains that are added as post-translational modifications to the mucin proteins. This gel provides an insoluble mucous barrier that serves to protect the intestinal epithelium.
The mucin 2 protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [7]
Mucins are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most animals. Mucins' key characteristic is their ability to form gels; therefore they are a key component in most gel-like secretions, serving functions from lubrication to cell signalling to forming chemical barriers. They often take an inhibitory role. Some mucins are associated with controlling mineralization, including nacre formation in mollusks, calcification in echinoderms and bone formation in vertebrates. They bind to pathogens as part of the immune system. Overexpression of the mucin proteins, especially MUC1, is associated with many types of cancer.
Mucin-5AC(MUC-5AC) is a protein that in humans is encoded by the MUC5AC gene.
Trefoil factor 1 is a protein that in humans is encoded by the TFF1 gene.
Trefoil factor 3 is a protein that in humans is encoded by the TFF3 gene.
Trefoil factor 2 is a protein that in humans is encoded by the TFF2 gene.
Mucin-5B(MUC-5B) is a protein that in humans is encoded by the MUC5B gene and by Muc5b gene in mouse. It is one of the five gel-forming mucins. MUC-5B can be found in whole saliva, normal lung mucus, and cervical mucus. In some diseases such as COPD, chronic rhinosinusitis (CRS), and H. pylori-associated gastric disease.
Chloride channel accessory 1 is a protein that in humans is encoded by the CLCA1 gene.
Mucin 6, oligomeric mucus/gel-forming, also known as MUC6, is a human gene encoding a protein of the same name. MUC6, along with MUC2, MUC5AC, and MUC5B, is located within the 11p15 chromosomal locus of chromosome 11. MUC6, along with MUC1, is expressed in normal pancreases.
Mucin-7 is a protein that in humans is encoded by the MUC7 gene. In animals, the MUC7 gene is found in most placental mammals, but not marsupials.
Porimin is a protein that in humans is encoded by the TMEM123 gene.
C-type lectin domain family 11 member A is a protein that in humans is encoded by the CLEC11A gene.
Homeobox protein Hox-C11 is a protein that in humans is encoded by the HOXC11 gene.
LIM homeobox transcription factor 1, alpha, also known as LMX1A, is a protein which in humans is encoded by the LMX1A gene.
Mucin 3A is a protein that in humans is encoded by the MUC3A gene.
Mucin-20 is a protein that in humans is encoded by the MUC20 gene.
Mucin and cadherin-like protein is a protein that in humans is encoded by the MUPCDH gene.
Tetraspanin-6 is a protein that in humans is encoded by the TSPAN6 gene.
A disintegrin and metalloproteinase with thrombospondin motifs 12 is an enzyme that in humans is encoded by the ADAMTS12 gene.
Mucin-17 is a protein that in humans is encoded by the MUC17 gene.
Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the NKX6-1 gene.
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