Normal pressure hydrocephalus

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Normal-pressure hydrocephalus
Other namesMalresorptive hydrocephalus
Specialty Neurology   OOjs UI icon edit-ltr-progressive.svg

Normal pressure hydrocephalus (NPH), also called malresorptive hydrocephalus, is a form of communicating hydrocephalus in which excess cerebrospinal fluid (CSF) builds up in the ventricles, leading to normal or slightly elevated cerebrospinal fluid pressure. As the fluid builds up, the ventricles to enlarge and the pressure inside the head to increase, compressing surrounding brain tissue and leading to neurological complications. Although the cause of idiopathic (also referred to as primary) NPH remains unclear, it has been associated with various co-morbidities including hypertension, diabetes mellitus, Alzheimer's disease, and hyperlipidemia. [1] [2] [3] Causes of secondary NPH include trauma, hemorrhage, or infection. [4] The disease presents in a classic triad of symptoms, which are memory impairment, urinary frequency, and balance problems/gait deviations (note: this diagnosis method is obsolete [5] [6] ). The disease was first described by Salomón Hakim and Raymond Adams in 1965. [7]

Contents

The treatment is surgical placement of a ventriculoperitoneal shunt to drain excess CSF into the lining of the abdomen where the CSF will eventually be absorbed. NPH is often misdiagnosed as other conditions including Meniere's disease (due to balance problems), Parkinson's disease (due to gait) or Alzheimer's disease (due to cognitive dysfunction).

Signs and symptoms

NPH exhibits a classic triad of clinical findings (known as the Adams triad or Hakim's triad). The triad consists of walking difficulty, reduced attention span, and urinary frequency or incontinence. Symptoms present insidiously over the course of 3–6 months. [4] The triad is considered obsolete for diagnostic purposes and newer guidelines are available. [5] [6]

Gait deviations/balance problems are present in nearly all NPH patients and are typically the first presenting symptom. This is caused by expansion of the lateral ventricles, which can impinge on the corticospinal tract motor fibers. The typical gait abnormality in NPH is a broad-based, slow, short-stepped, "stuck to the floor", or "magnetic" movement. The gait abnormalities in NPH may bear resemblance to a gait associated with Parkinson's disease. The gait deviation can be classified as mild, marked, or severe: "marked" is when the patient has difficulty walking because of considerable instability; "severe" is when it is not possible for the patient to walk without aids (such as a cane or a wheeled walker). [8] [9] An associated tremor of the hands, legs, or feet can be seen in up to 40% of NPH patients. [10]

Dementia presents as progressive cognitive impairment which is present in 60% of patients at time of treatment. This is caused by distortions predominantly at the frontal lobe and the subcortex. [11] Initial deficits involve planning, organization, attention, and concentration. Further deficits include difficulty managing finances, taking medications, driving, keeping track of appointments, daytime sleeping, short-term memory impairments, and psychomotor slowing. Late-stage features include apathy, reduced drive, slowed thinking, and reduced speech.

Urinary incontinence appears late in the illness and is present in 50% of patients at time of treatment. Urinary dysfunction begins as increased frequency often at night and progresses to urge incontinence and permanent incontinence. [11]

Pathogenesis

Every day, the body makes roughly 600–700 ml of CSF, and about the same amount is reabsorbed into the bloodstream. Hydrocephalus is caused by an imbalance between the amount of fluid produced and its absorption rate. Enlarged ventricles put increased pressure on the adjacent cortical tissue and cause myriad effects in the patient, including distortion of the fibers in the corona radiata. This leads to an increase in intracranial pressure (ICP). The ICP gradually falls but remains slightly elevated, and the CSF pressure reaches a high normal level of 15 to 20 cm H2O. Measurements of ICP, therefore, are not usually elevated. Because of this, patients do not exhibit the classic signs that accompany increased intracranial pressure such as headache, nausea, vomiting, or altered consciousness, although some studies have shown pressure elevations to occur intermittently. [12] [13]

The exact pathogenesis is unknown, but consensus on some mechanisms include: [14]

The syndrome is often divided into two groups, primary (also called idiopathic) and secondary, based on cause. The underlying etiology of primary NPH has not yet been identified. Primary NPH affects adults age 40 years or older, most commonly in adults over 60. [15] Secondary NPH can affect persons of any age and occurs due to conditions such as subarachnoid hemorrhage, meningitis, brain surgery, brain radiation, or traumatic brain injury. [16] These conditions are thought to lead to increased inflammation of the arachnoid granulations, which further leads to decreased CSF reabsorption and therefore enlargement of ventricles. [17]

Symptoms of gait deviation, neurological impairment, and urinary incontinence seen in NPH are due to compression of the corresponding regions of the brain that control these functions. Gait abnormalities are thought to be due to compression of the corticospinal tract fibers in the corona radiata that coordinate motor movements of the legs. [14] Compression of the brainstem as well as poor perfusion of the periventricular white matter in the prefrontal cortex are also thought to contribute to gait deviations in NPH. [14] Dementia in NPH is most likely caused by ventricular enlargement compressing the calvarium, which further leads to tearing of currently unidentified nerve fibers. [14] Lastly, urinary incontinence is thought to be caused by stretching of the periventricular sacral fibers of the corticospinal tract fibers leading to loss of voluntary bladder contraction. [14] [18]

Diagnosis

Evan's index is the ratio of maximum width of the frontal horns to the maximum width of the inner table of the cranium. An Evan's index more than 0.31 indicates hydrocephalus. CT of Evan's index.jpg
Evan's index is the ratio of maximum width of the frontal horns to the maximum width of the inner table of the cranium. An Evan's index more than 0.31 indicates hydrocephalus.

Patients with suspected idiopathic NPH should have at least one of the symptoms in Hakim's triad (gait disturbance, urinary incontinence, and cognitive impairment) in addition to ventricular enlargement on neuroimaging. An extensive and detailed patient history is required in order to exclude other diseases that may explain the patient's symptoms. Known causes of secondary NPH (head injury, meningitis, hemorrhage) should be ruled out prior to further investigation of idiopathic NPH. [4]

The international evidenced-based diagnostic criteria for primary, or idiopathic, NPH are: [20]

Typical imaging findings in normal pressure hydrocephalus versus brain atrophy. [21]
Normal pressure hydrocephalus versus atrophy, NPH.jpg Normal pressure hydrocephalus versus atrophy, CA.jpg
Normal pressure hydrocephalus Brain atrophy
Preferable projection Coronal plane at the level of the posterior commissure of the brain.
Modality in this example CT MRI
CSF spaces over the convexity near the vertex (red ellipse Red ellipse.png )Narrowed convexity ("tight convexity") as well as medial cisternsWidened vertex (red arrow) and medial cisterns (green arrow)
Callosal angle (blue V) Acute angle Obtuse angle
Most likely cause of leucoaraiosis (periventricular signal alterations, blue arrows Flecha tesela.svg )Transependymal cerebrospinal fluid diapedesisVascular encephalopathy, in this case suggested by unilateral occurrence

MRI scans are the preferred imaging. The distinction between normal and enlarged ventricular size by cerebral atrophy is difficult to ascertain. Up to 80% of cases are unrecognized and untreated due to difficulty of diagnosis. [22] Imaging should also reveal the absence of any cerebral mass lesions or any signs of obstructions. Although all patients with NPH have enlarged ventricles, not all elderly patients with enlarged ventricles have primary NPH. Cerebral atrophy can cause enlarged ventricles, as well, and is referred to as hydrocephalus ex vacuo.

Image of patient receiving lumbar puncture (LP). Cerebrospinal fluid (CSF) obtained from an LP can be tested to aid in the diagnosis of NPH. Wikipedian getting a lumbar puncture (2006).jpg
Image of patient receiving lumbar puncture (LP). Cerebrospinal fluid (CSF) obtained from an LP can be tested to aid in the diagnosis of NPH.

The Miller Fisher test involves a high-volume lumbar puncture (LP) with removal of 30–50 ml of CSF. Gait and cognitive function are typically tested just before and within 2–3 hours after the LP to assess for signs of symptomatic improvement. The CSF infusion test can also be used to aid in diagnosis of NPH. During the CSF infusion test, a ringer lactate solution is infused into a spinal needle while another spinal needle is used to record numerous CSF pressure variables including ICP, outflow resistance, and CSF formation rate. [23] The tests have a positive predictive value over 90%, but a negative predictive value less than 50%. The LP should show normal or mildly elevated CSF pressure. CSF should have normal cell contents, glucose levels, and protein levels. [24] [25] [26]

Treatment

Ventriculoperitoneal shunts

Diagram demonstrating surgical placement of a VP shunt used to manage NPH. Diagram showing a brain shunt CRUK 052.svg
Diagram demonstrating surgical placement of a VP shunt used to manage NPH.

For suspected cases of NPH, CSF shunting is the first-line treatment. The most common type used to treat NPH is ventriculoperitoneal (VP) shunts, which drain CSF fluid to the peritoneal cavity. Adjustable valves allow fine-tuning of CSF drainage. NPH symptoms reportedly improve in 70–90% of patients with CSF shunt. Risk-benefit analyses have shown beyond any doubt that surgery for NPH is far better than conservative treatment or the natural course. [22] VP shunt is less likely to be recommended in those who have severe dementia at time of NPH diagnosis, regardless of findings found on MRI or CT. [10] [27]

Gait symptoms improve in ≥ 85% patients. Cognitive symptoms improve in up to 80% of patients when surgery is performed early in the disease course. Urgency and incontinence improve in up to 80% of patients, but only in ≤ 50–60% of patients with shunt implanted late in disease course. The most likely patients to show improvement are those who show only gait deviation, mild or no incontinence, and mild dementia. The risk of adverse events related to shunt placement is 11%, including shunt failure, infections such as ventriculitis, shunt obstruction, over- or under-drainage, and development of a subdural hematoma. [28] [29] [30]

Medications

No medications are effective for primary NPH. Lasting reductions in ICP have not been demonstrated with acetazolamide. [31] Transient reduction in ICP after administration of an acetazolamide bolus has been shown to be a positive predictor for good response after VP shunt placement in NPH patients.

Research is currently aimed at finding other medication options for the management of NPH symptoms. Steroids have demonstrated decreased production of CSF in animal studies on healthy rabbits and dogs, however further testing is required to determine if this is an effective treatment option in humans. [32] [33] [34] A trial of triamterene in adults with chronic hydrocephalus has also shown improvement of symptoms within 12 weeks, however further research is needed to support this as a non-surgical option for NPH. [32]

Outcomes and Prognosis

The prognosis for patients with NPH varies depending on cause, severity of symptoms, and time to diagnosis. If left untreated, symptoms of gait disturbance, cognitive impairment, and urinary incontinence may continue to worsen and ultimately lead to death. Patients with a successful VP shunt can live a typically normal life with no restrictions to activities of daily living. [35] According to a recent study, gait imbalance appears to be the symptom that improves the most for patients after placement of a VP shunt. [36]

Epidemiology

Approximately half of all cases are primary (or idiopathic) NPH. [15] Incidence is estimated to 0.3–3% in patients older than 60 years and raising with older age. [37] Its prevalence is reported to be less than 1% in persons under the age of 65, and up to 3% for persons aged 65 or older. No difference in incidence is seen between men and women or amongst differing ethnicities. [38] [11] [39] [40] Among individuals with dementia, the incidence of NPH is thought to be between 2 and 6%.

History

NPH was first described by neurosurgeon Salomón Hakim in 1957 at the Hospital San Juan de Dios, located in Bogotá, Colombia. Hakim was contacted by the family of a 16-year-old male patient who, after suffering from severe head trauma in a motor vehicle accident, remained semi-comatose after surgery to relieve pressure from a subdural hematoma. Hakim soon discovered ventricular enlargement on imaging of the patient, however, the patient's intracranial pressure remained within normal limits. Hakim decided to remove CSF for laboratory testing and later implanted a ventriculoatrial shunt, after which the patient showed significant improvement to Hakim's surprise. These findings were later published as a case report by Hakim in 1964 in The New England Journal of Medicine . Hakim continued to research and work with patients found to have NPH and later published his findings detailing the classic triad of gait disturbance, neurological impairment, and urinary incontinence. [41]

See also

Related Research Articles

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Cerebrospinal fluid (CSF) is a clear, colorless body fluid found within the tissue that surrounds the brain and spinal cord of all vertebrates.

<span class="mw-page-title-main">Idiopathic intracranial hypertension</span> Medical condition

Idiopathic intracranial hypertension (IIH), previously known as pseudotumor cerebri and benign intracranial hypertension, is a condition characterized by increased intracranial pressure without a detectable cause. The main symptoms are headache, vision problems, ringing in the ears, and shoulder pain. Complications may include vision loss.

<span class="mw-page-title-main">Hydrocephalus</span> Abnormal increase in cerebrospinal fluid in the ventricles of the brain

Hydrocephalus is a condition in which an accumulation of cerebrospinal fluid (CSF) occurs within the brain. This typically causes increased pressure inside the skull. Older people may have headaches, double vision, poor balance, urinary incontinence, personality changes, or mental impairment. In babies, it may be seen as a rapid increase in head size. Other symptoms may include vomiting, sleepiness, seizures, and downward pointing of the eyes.

<span class="mw-page-title-main">Colpocephaly</span> Medical condition

Colpocephaly is a cephalic disorder involving the disproportionate enlargement of the occipital horns of the lateral ventricles and is usually diagnosed early after birth due to seizures. It is a nonspecific finding and is associated with multiple neurological syndromes, including agenesis of the corpus callosum, Chiari malformation, lissencephaly, and microcephaly. Although the exact cause of colpocephaly is not known yet, it is commonly believed to occur as a result of neuronal migration disorders during early brain development, intrauterine disturbances, perinatal injuries, and other central nervous system disorders. Individuals with colpocephaly have various degrees of motor disabilities, visual defects, spasticity, and moderate to severe intellectual disability. No specific treatment for colpocephaly exists, but patients may undergo certain treatments to improve their motor function or intellectual disability.

<span class="mw-page-title-main">Intracranial pressure</span> Pressure exerted by fluids inside the skull and on the brain

Intracranial pressure (ICP) is the pressure exerted by fluids such as cerebrospinal fluid (CSF) inside the skull and on the brain tissue. ICP is measured in millimeters of mercury (mmHg) and at rest, is normally 7–15 mmHg for a supine adult. The body has various mechanisms by which it keeps the ICP stable, with CSF pressures varying by about 1 mmHg in normal adults through shifts in production and absorption of CSF.

Cerebral atrophy is a common feature of many of the diseases that affect the brain. Atrophy of any tissue means a decrement in the size of the cell, which can be due to progressive loss of cytoplasmic proteins. In brain tissue, atrophy describes a loss of neurons and the connections between them. Brain atrophy can be classified into two main categories: generalized and focal atrophy. Generalized atrophy occurs across the entire brain whereas focal atrophy affects cells in a specific location. If the cerebral hemispheres are affected, conscious thought and voluntary processes may be impaired.

<span class="mw-page-title-main">Arachnoid cyst</span> Medical condition

Arachnoid cysts are cerebrospinal fluid covered by arachnoidal cells and collagen that may develop between the surface of the brain and the cranial base or on the arachnoid membrane, one of the three meningeal layers that cover the brain and the spinal cord. Primary arachnoid cysts are a congenital disorder whereas secondary arachnoid cysts are the result of head injury or trauma. Most cases of primary cysts begin during infancy; however, onset may be delayed until adolescence.

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<span class="mw-page-title-main">Cerebral shunt</span> Surgical implant to treat hydrocephalus

A cerebral shunt is a device permanently implanted inside the head and body to drain excess fluid away from the brain. They are commonly used to treat hydrocephalus, the swelling of the brain due to excess buildup of cerebrospinal fluid (CSF). If left unchecked, the excess CSF can lead to an increase in intracranial pressure (ICP), which can cause intracranial hematoma, cerebral edema, crushed brain tissue or herniation. The drainage provided by a shunt can alleviate or prevent these problems in patients with hydrocephalus or related diseases.

<span class="mw-page-title-main">External ventricular drain</span> Medical device

An external ventricular drain (EVD), also known as a ventriculostomy or extraventricular drain, is a device used in neurosurgery to treat hydrocephalus and relieve elevated intracranial pressure when the normal flow of cerebrospinal fluid (CSF) inside the brain is obstructed. An EVD is a flexible plastic catheter placed by a neurosurgeon or neurointensivist and managed by intensive care unit (ICU) physicians and nurses. The purpose of external ventricular drainage is to divert fluid from the ventricles of the brain and allow for monitoring of intracranial pressure. An EVD must be placed in a center with full neurosurgical capabilities, because immediate neurosurgical intervention can be needed if a complication of EVD placement, such as bleeding, is encountered.

<span class="mw-page-title-main">CSF tap test</span>

The CSF tap test, sometimes lumbar tap test or Miller Fisher Test, is a medical test that is used to decide whether shunting of cerebrospinal fluid (CSF) would be helpful in a patient with suspected normal pressure hydrocephalus (NPH). The test involves removing 30-50 ml of cerebrospinal fluid (CSF) through a lumbar puncture, after which motor and cognitive function is clinically reassessed. The name "Fisher test" is after C. Miller Fisher, a Canadian neurologist working in Boston, Massachusetts, who described the test.

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References

  1. ↑ Pyykkö, Okko T.; Nerg, Ossi; Niskasaari, Hanna-Mari; Niskasaari, Timo; Koivisto, Anne M.; Hiltunen, Mikko; Pihlajamäki, Jussi; Rauramaa, Tuomas; Kojoukhova, Maria; Alafuzoff, Irina; Soininen, Hilkka; Jääskeläinen, Juha E.; Leinonen, Ville (April 2018). "Incidence, Comorbidities, and Mortality in Idiopathic Normal Pressure Hydrocephalus". World Neurosurgery. 112: e624–e631. doi:10.1016/j.wneu.2018.01.107. ISSN   1878-8769. PMID   29374607.
  2. ↑ Kuriyama, Nagato; Miyajima, Masakazu; Nakajima, Madoka; Kurosawa, Michiko; Fukushima, Wakaba; Watanabe, Yoshiyuki; Ozaki, Etsuko; Hirota, Yoshio; Tamakoshi, Akiko; Mori, Etsuro; Kato, Takeo; Tokuda, Takahiko; Urae, Akinori; Arai, Hajime (March 2017). "Nationwide hospital-based survey of idiopathic normal pressure hydrocephalus in Japan: Epidemiological and clinical characteristics". Brain and Behavior. 7 (3): e00635. doi:10.1002/brb3.635. ISSN   2162-3279. PMC   5346522 . PMID   28293475.
  3. ↑ Liew, Boon Seng; Takagi, Kiyoshi; Kato, Yoko; Duvuru, Shyam; Thanapal, Sengottuvel; Mangaleswaran, Balamurugan (2019). "Current Updates on Idiopathic Normal Pressure Hydrocephalus". Asian Journal of Neurosurgery. 14 (3): 648–656. doi: 10.4103/ajns.AJNS_14_19 . ISSN   1793-5482. PMC   6703007 . PMID   31497081.
  4. 1 2 3 Williams, Michael A.; Malm, Jan (April 2016). "Diagnosis and Treatment of Idiopathic Normal Pressure Hydrocephalus". Continuum (Minneapolis, Minn.). 22 (2 Dementia): 579–599. doi:10.1212/CON.0000000000000305. ISSN   1538-6899. PMC   5390935 . PMID   27042909.
  5. 1 2 Nakajima, Madoka; et al. (Feb 2021). "Guidelines for Management of Idiopathic Normal Pressure Hydrocephalus (Third Edition): Endorsed by the Japanese Society of Normal Pressure Hydrocephalus". Neurologia Medico-chirurgica (Tokyo). 61 (2): 63–97. doi:10.2176/nmc.st.2020-0292. PMC   7905302 . PMID   33455998.
  6. 1 2 "Normal Pressure Hydrocephalus: a neurologist's perspective". YouTube . 2022-11-01. Retrieved 2022-08-10.
  7. ↑ Adams RD, Fisher CM, Hakim S, Ojemann RG, Sweet WH (July 1965). "Symptomatic Occult Hydrocephalus with Normal Cerebrospinal-Fluid Pressure". The New England Journal of Medicine. 273 (3): 117–26. doi:10.1056/NEJM196507152730301. PMID   14303656.
  8. ↑ Krauss JK, Faist M, Schubert M, Borremans JJ, Lucking CH, Berger W (2001). "Evaluation of Gait in Normal Pressure Hydrocephalus Before and After Shunting". In Ruzicka E, Hallett M, Jankovic J (eds.). Gait Disorders. Philadelphia, PA: Lippincott Williams & Wilkins. pp. 301–09.
  9. ↑ Ropper AH, Samuels MA (2009). Adams and Victor's Principles of Neurology (9th ed.). New York: McGraw-Hill Medical.
  10. 1 2 Shprecher, David; Schwalb, Jason; Kurlan, Roger (September 2008). "Normal pressure hydrocephalus: diagnosis and treatment". Current Neurology and Neuroscience Reports. 8 (5): 371–376. doi:10.1007/s11910-008-0058-2. ISSN   1534-6293. PMC   2674287 . PMID   18713572.
  11. 1 2 3 Younger DS (2005). "Adult Normal Pressure Hydrocephalus". In Younger DS (ed.). Motor Disorders (2nd ed.). Philadelphia, PA: Lippincott Williams & Wilkins. pp. 581–84.
  12. ↑ Factora, Ronan (May 2006). "When do common symptoms indicate normal pressure hydrocephalus?". Cleveland Clinic Journal of Medicine. 73 (5): 447–450, 452, 455–456 passim. doi:10.3949/ccjm.73.5.447. ISSN   0891-1150. PMID   16708712. S2CID   38707248.
  13. ↑ Pinto, Venessa L.; Tadi, Prasanna; Adeyinka, Adebayo (2024), "Increased Intracranial Pressure", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID   29489250 , retrieved 2024-01-25
  14. 1 2 3 4 5 6 M Das, Joe; Biagioni, Milton C. (2023), "Normal Pressure Hydrocephalus", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID   31194404 , retrieved 2024-01-22
  15. 1 2 Oliveira, Louise Makarem; Nitrini, Ricardo; Román, Gustavo C. (2019). "Normal-pressure hydrocephalus: A critical review". Dementia & Neuropsychologia. 13 (2): 133–143. doi:10.1590/1980-57642018dn13-020001. ISSN   1980-5764. PMC   6601311 . PMID   31285787.
  16. ↑ Greenberg, Mark (2016). Handbook of Neurosurgery (8th ed.). New York: Thiem e Medical Publishers, Inc. pp. 404–405. ISBN   978-1-62623-241-9.
  17. ↑ Passos-Neto, Carlos Eduardo Borges; Lopes, Cesar Castello Branco; Teixeira, Mauricio Silva; Studart Neto, Adalberto; Spera, Raphael Ribeiro (May 2022). "Normal pressure hydrocephalus: an update". Arquivos de Neuro-Psiquiatria. 80 (5 Suppl 1): 42–52. doi:10.1590/0004-282X-ANP-2022-S118. ISSN   1678-4227. PMC   9491444 . PMID   35976308.
  18. ↑ Gleason, P. L.; Black, P. M.; Matsumae, M. (October 1993). "The neurobiology of normal pressure hydrocephalus". Neurosurgery Clinics of North America. 4 (4): 667–675. doi:10.1016/S1042-3680(18)30558-8. ISSN   1042-3680. PMID   8241789.
  19. ↑ Ishii M, Kawamata T, Akiguchi I, Yagi H, Watanabe Y, Watanabe T, Mashimo H (March 2010). "Parkinsonian Symptomatology May Correlate with CT Findings before and after Shunting in Idiopathic Normal Pressure Hydrocephalus". Parkinson's Disease. 2010: 1–7. doi: 10.4061/2010/201089 . PMC   2951141 . PMID   20948890.
  20. ↑ Nakajima, Madoka; Yamada, Shigeki; Miyajima, Masakazu; Ishii, Kazunari; Kuriyama, Nagato; Kazui, Hiroaki; Kanemoto, Hideki; Suehiro, Takashi; Yoshiyama, Kenji; Kameda, Masahiro; Kajimoto, Yoshinaga; Mase, Mitsuhito; Murai, Hisayuki; Kita, Daisuke; Kimura, Teruo (2021-02-15). "Guidelines for Management of Idiopathic Normal Pressure Hydrocephalus (Third Edition): Endorsed by the Japanese Society of Normal Pressure Hydrocephalus". Neurologia Medico-Chirurgica. 61 (2): 63–97. doi:10.2176/nmc.st.2020-0292. ISSN   1349-8029. PMC   7905302 . PMID   33455998.
  21. ↑ Damasceno BP (2015). "Neuroimaging in normal pressure hydrocephalus". Dementia & Neuropsychologia. 9 (4): 350–355. doi:10.1590/1980-57642015DN94000350. PMC   5619317 . PMID   29213984.
  22. 1 2 Kiefer M, Unterberg A (January 2012). "The differential diagnosis and treatment of normal-pressure hydrocephalus". Deutsches Ärzteblatt International. 109 (1–2): 15–25, quiz 26. doi:10.3238/arztebl.2012.0015. PMC   3265984 . PMID   22282714.
  23. ↑ Williams, Michael A.; Malm, Jan (April 2016). "Diagnosis and Treatment of Idiopathic Normal Pressure Hydrocephalus". Continuum (Minneapolis, Minn.). 22 (2 Dementia): 579–599. doi:10.1212/CON.0000000000000305. ISSN   1538-6899. PMC   5390935 . PMID   27042909.
  24. ↑ Tarnaris A, Toma AK, Kitchen ND, Watkins LD (December 2009). "Ongoing search for diagnostic biomarkers in idiopathic normal pressure hydrocephalus". Biomarkers in Medicine. 3 (6): 787–805. doi:10.2217/bmm.09.37. PMID   20477715.
  25. ↑ Marmarou A, Bergsneider M, Klinge P, Relkin N, Black PM (September 2005). "The value of supplemental prognostic tests for the preoperative assessment of idiopathic normal-pressure hydrocephalus". Neurosurgery. 57 (3 Suppl): S17–28, discussion ii–v. doi:10.1227/01.neu.0000168184.01002.60. PMID   16160426. S2CID   7566152.
  26. ↑ "NINDS Normal Pressure Hydrocephalus Information Page". National Institute of Neurological Disorders and Stroke. 29 April 2011. Archived from the original on 11 December 2016. Retrieved 13 May 2011.
  27. ↑ Vanneste, J. A. (January 2000). "Diagnosis and management of normal-pressure hydrocephalus". Journal of Neurology. 247 (1): 5–14. doi:10.1007/s004150050003. ISSN   0340-5354. PMID   10701891. S2CID   12790649.
  28. ↑ Marmarou A, Young HF, Aygok GA (April 2007). "Estimated incidence of normal pressure hydrocephalus and shunt outcome in patients residing in assisted-living and extended-care facilities". Neurosurgical Focus. 22 (4): E1. doi: 10.3171/foc.2007.22.4.2 . PMID   17613187.
  29. ↑ Vanneste J, Augustijn P, Dirven C, Tan WF, Goedhart ZD (January 1992). "Shunting normal-pressure hydrocephalus: do the benefits outweigh the risks? A multicenter study and literature review". Neurology. 42 (1): 54–59. doi:10.1212/wnl.42.1.54. PMID   1734324. S2CID   29656326.
  30. ↑ Poca MA, Mataró M, Del Mar Matarín M, Arikan F, Junqué C, Sahuquillo J (May 2004). "Is the placement of shunts in patients with idiopathic normal-pressure hydrocephalus worth the risk? Results of a study based on continuous monitoring of intracranial pressure". Journal of Neurosurgery. 100 (5): 855–66. doi:10.3171/jns.2004.100.5.0855. PMID   15137605.
  31. ↑ Miyake, H.; Ohta, T.; Kajimoto, Y.; Deguchi, J. (1999-11-15). "Diamox ® Challenge Test to Decide Indications for Cerebrospinal Fluid Shunting in Normal Pressure Hydrocephalus". Acta Neurochirurgica. 141 (11): 1187–1193. doi:10.1007/s007010050417. ISSN   0001-6268. PMID   10592119. S2CID   2819074.
  32. 1 2 Del Bigio, Marc R.; Di Curzio, Domenico L. (2016-02-05). "Nonsurgical therapy for hydrocephalus: a comprehensive and critical review". Fluids and Barriers of the CNS. 13: 3. doi: 10.1186/s12987-016-0025-2 . ISSN   2045-8118. PMC   4743412 . PMID   26846184.
  33. ↑ Lindvall-Axelsson, M.; Hedner, P.; Owman, C. (October 1989). "Corticosteroid action on choroid plexus: Reduction in Na+?K+-ATPase activity, choline transport capacity, and rate of CSF formation". Experimental Brain Research. 77 (3): 605–610. doi:10.1007/BF00249613. ISSN   0014-4819. PMID   2553468. S2CID   44019348.
  34. ↑ Weiss, Martin H.; Nulsen, Frank E. (April 1970). "The Effect of Glucocorticoids on CSF Flow in Dogs". Journal of Neurosurgery. 32 (4): 452–458. doi:10.3171/jns.1970.32.4.0452. ISSN   0022-3085. PMID   5417941.
  35. ↑ Savolainen, S.; Hurskainen, H.; Paljärvi, L.; Alafuzoff, I.; Vapalahti, M. (June 2002). "Five-year outcome of normal pressure hydrocephalus with or without a shunt: predictive value of the clinical signs, neuropsychological evaluation and infusion test". Acta Neurochirurgica. 144 (6): 515–523, discussion 523. doi:10.1007/s00701-002-0936-3. ISSN   0001-6268. PMID   12111484. S2CID   24582223.
  36. ↑ Wu, Eva M.; El Ahmadieh, Tarek Y.; Kafka, Benjamin; Caruso, James; Aoun, Salah G.; Plitt, Aaron R.; Neeley, Om; Olson, Daiwai M.; Ruchinskas, Robert A.; Cullum, Munro; Batjer, Hunt; White, Jonathan A. (2019-03-04). "Ventriculoperitoneal Shunt Outcomes of Normal Pressure Hydrocephalus: A Case Series of 116 Patients". Cureus. 11 (3): e4170. doi: 10.7759/cureus.4170 . ISSN   2168-8184. PMC   6502283 . PMID   31093469.
  37. ↑ Jaraj D, Rabiei K, Marlow T, Jensen C, Skoog I, Wikkelsø C (April 2014). "Prevalence of idiopathic normal-pressure hydrocephalus". Neurology. 82 (16): 1449–54. doi:10.1212/WNL.0000000000000342. PMC   4001197 . PMID   24682964.
  38. ↑ "Normal Pressure Hydrocephalus (NPH): Symptoms & Treatment". Cleveland Clinic. Retrieved 2024-01-22.
  39. ↑ Brean A, Eide PK (July 2008). "Prevalence of probable idiopathic normal pressure hydrocephalus in a Norwegian population". Acta Neurologica Scandinavica. 118 (1): 48–53. doi:10.1111/j.1600-0404.2007.00982.x. hdl: 10852/27953 . PMID   18205881. S2CID   25605575.
  40. ↑ Tanaka N, Yamaguchi S, Ishikawa H, Ishii H, Meguro K (1 January 2009). "Prevalence of possible idiopathic normal-pressure hydrocephalus in Japan: the Osaki-Tajiri project". Neuroepidemiology. 32 (3): 171–5. doi:10.1159/000186501. PMID   19096225. S2CID   39139263.
  41. ↑ Wallenstein, Matthew B.; McKhann, Guy M. (July 2010). "Salomón Hakim and the Discovery of Normal-Pressure Hydrocephalus". Neurosurgery. 67 (1): 155–159. doi:10.1227/01.NEU.0000370058.12120.0E. ISSN   0148-396X. PMID   20568668. S2CID   34287029.
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