Pineocytoma

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Pineocytoma
Other namesPinealocytoma
Pineocytoma - high mag.jpg
Micrograph of a pineocytoma. HPS stain.
Specialty Oncology   OOjs UI icon edit-ltr-progressive.svg
Symptoms Parinaud syndrome, nausea, vision abnormalities, hydrocephalus, and headaches. [1]
Usual onset20-60 years of age. [2]
Diagnostic method MRI and CT scan. [2]
Differential diagnosis Pineoblastoma, pineal cyst, germ cell tumors, and metastasis. [2]
TreatmentSurgical excision. [2]
Prognosis 86% 5-year survival rate. [2]

Pineocytoma, is a rare, benign, slowly growing tumor of the pineal gland. The pineal gland is a small endocrine gland close to the center of the brain that secretes melatonin into the bloodstream. Pineocytomas can cause pressure and fluid build-up in the brain. They are more common in adults. Symptoms include vision problems, nausea, vomiting, memory problems, and headaches. [3]

Contents

Signs and symptoms

Because of their massive growth, pineocytoma symptoms are related to increased intracranial pressure. Some common symptoms of pineocytomas include Parinaud syndrome, headaches, dizziness, papilledema, tremors, ataxia, impaired vision, ambulation, ptosis, nausea, and vomiting. [4]

Causes

The true cause of pineocytomas is unknown. No genetic mutations have been linked to pineocytomas however, there have been some associations with certain chromosomal abnormalities. There are no known risk factors for pineocytomas. [4]

Diagnosis

Pineocytomas typically present on a CT scan as round and well-delineated masses with a diameter under 3cm. Pineocytomas are homogeneous, hypodense, and sometimes have central or peripheral calcification. On an MRI a pineocytoma often appears isointense or hypointense in T1-weighted scans. However, they usually appear hyperintense on T2-weighted scans. The diagnosis of a pineocytoma is confirmed by a brain biopsy. [4]

Management

The main treatment options for pineocytomas are gross total resection, subtotal resection, and radiation. [5]

See also

Related Research Articles

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<span class="mw-page-title-main">Headache</span> Pain in the head, neck, or face

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<span class="mw-page-title-main">Pineal gland</span> Endocrine gland in the brain of most vertebrates

The pineal gland is a small endocrine gland in the brain of most vertebrates. The pineal gland produces melatonin, a serotonin-derived hormone which modulates sleep patterns in both circadian and seasonal cycles. The shape of the gland resembles a pine cone, which gives it its name. The pineal gland is located in the epithalamus, near the center of the brain, between the two hemispheres, tucked in a groove where the two halves of the thalamus join. It is one of the neuroendocrine secretory circumventricular organs in which capillaries are mostly permeable to solutes in the blood.

<span class="mw-page-title-main">Prolactinoma</span> Medical condition

A prolactinoma is a tumor (adenoma) of the pituitary gland that produces the hormone prolactin. It is the most common type of functioning pituitary tumor. Symptoms of prolactinoma are due to abnormally high levels of prolactin in the blood (hyperprolactinemia), or due to pressure of the tumor on surrounding tissues. Based on size, a prolactinoma can be classified as a microprolactinoma or a macroprolactinoma.

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<span class="mw-page-title-main">Craniopharyngioma</span> Medical condition

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<span class="mw-page-title-main">Pinealoma</span> Medical condition

A pinealoma is a tumor of the pineal gland, a part of the brain that produces melatonin. If a pinealoma destroys the cells of the pineal gland in a child, it can cause precocious puberty.

<span class="mw-page-title-main">Empty sella syndrome</span> Medical condition

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<span class="mw-page-title-main">Pineal gland cyst</span> Medical condition

A pineal gland cyst is a usually benign (non-malignant) cyst in the pineal gland, a small endocrine gland in the brain. Historically, these fluid-filled bodies appeared on 1-4% of magnetic resonance imaging (MRI) brain scans, but were more frequently diagnosed at death, seen in 4-11% of autopsies. A 2007 study by Pu et al. found a frequency of 23% in brain scans.

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<span class="mw-page-title-main">Central nervous system cyst</span> Medical condition

A central nervous system cyst is a type of cyst that presents and affects part of the central nervous system (CNS). They are usually benign and filled with either cerebrospinal fluid, blood, or tumor cells. CNS cysts are classified into two categories: cysts that originate from non-central nervous system tissue, migrate to, and form on a portion of the CNS, and cysts that originate within central nervous system tissue itself. Within these two categories, there are many types of CNS cysts that have been identified from previous studies.

<span class="mw-page-title-main">Pineoblastoma</span> Medical condition

Pineoblastoma is a malignant tumor of the pineal gland. A pineoblastoma is a supratentorial midline primitive neuroectodermal tumor. Pineoblastoma can present at any age, but is most common in young children. They account for 0.001% of all primary CNS neoplasms.

<span class="mw-page-title-main">Astroblastoma</span> Medical condition

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<span class="mw-page-title-main">Papillary tumors of the pineal region</span> Type of brain tumor

Papillary tumors of the pineal region were first described by A. Jouvet et al. in 2003 and were introduced in the World Health Organization (WHO) classification of central nervous system in 2007. Papillary Tumors of the Pineal Region are located on the pineal gland which is located in the center of the brain. The pineal gland is located on roof of the diencephalon. It is a cone-shaped structure dorsal to the midbrain tectum. The tumor appears to be derived from the specialized ependymal cells of the subcommissural organ. Papillary tumors of the central nervous system and particularly of the pineal region are very rare and so diagnosing them is extremely difficult.

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References

  1. "National Organization for Rare Disorders". National Organization for Rare Disorders. June 16, 2022. Retrieved November 24, 2023.
  2. 1 2 3 4 5 Gaillard, Frank (January 7, 2022). "Radiology Reference Article". Radiopaedia. Retrieved November 24, 2023.
  3. "Pineocytoma". AdventHealth Neuroscience Institute. Retrieved November 24, 2023.
  4. 1 2 3 Moini, Jahangir; Badolato, Craig; Ahangari, Raheleh (2020). "Pineal Tumors". Epidemiology of Endocrine Tumors. Elsevier. pp. 201–214. doi:10.1016/b978-0-12-822187-7.00015-3. ISBN   9780128221877. S2CID   240653465 . Retrieved November 24, 2023.
  5. Hsieh, Chi-Chih; Chen, Jui-Sheng (2022). "Radiotherapy After Endoscopic Biopsy in an Adult with Pineocytoma, the Rare Brain Tumor in an Adult: A Case Report and Literature Review". International Medical Case Reports Journal. Informa UK Limited. 15: 307–311. doi: 10.2147/imcrj.s367293 . ISSN   1179-142X. PMC   9215869 . PMID   35755243 . Retrieved November 24, 2023.