The N1 is a national route in South Africa that runs from Cape Town through Bloemfontein, Johannesburg, Pretoria and Polokwane to Beit Bridge on the border with Zimbabwe. It forms the first section of the famed Cape to Cairo Road.
The R21 is a major north–south provincial route in eastern Gauteng Province, South Africa. Built in the early 1970s, it remains one of two freeways linking Pretoria with Johannesburg, via the R24. As the eastern of the two freeways, it links the Pretoria city centre with OR Tambo International Airport, the N12 freeway, and Boksburg. Between the Solomon Mahlangu Drive on-ramp in Monument Park, Pretoria, and the N12 in Boksburg, the R21 is an 8 lane highway and motorway (freeway), with 4 lanes in each direction. It has off-ramps leading to Irene, Olifantsfontein, Benoni, and Kempton Park, including a partial offramp to Atlas Road. The route intersects the N1 Highway near Centurion, the R24 near the airport, the N12 and N17 in Boksburg, and the N3 near Vosloorus on the East Rand, where it ends. The section from the N12 to the N3 is not a freeway. As early as the 1970s there were proposals to extend the R21 freeway further south and the freeway may be linked with the current eastern terminus of the M2 in Germiston in future. It is also designated as the P157.
The R25 is a provincial route in South Africa that connects Johannesburg with Groblersdal via Kempton Park, Bapsfontein and Bronkhorstspruit.
The R33 is a provincial route in South Africa that connects Pietermaritzburg with Lephalale via Greytown, Paulpietersburg, Carolina, Belfast and Vaalwater. It is a very long road, passing through 3 provinces.
The R35 is a provincial route in Mpumalanga, South Africa that connects Amersfoort with Middelburg via Morgenzon and Bethal. The R35 used to connect with the N3 near Ladysmith, but the portion of the road from Amersfoort onwards is now part of the N11.
The R37 is a provincial route in South Africa that connects Polokwane with Nelspruit (Mbombela) via Burgersfort and Lydenburg.
The R38 is a provincial route in South Africa that connects Standerton with Kaapmuiden via Bethal, Carolina and Barberton. It is a main route through the province of Mpumalanga.
The R40 is a provincial route in South Africa that connects the Eswatini border at Bulembu via Barberton, Nelspruit and Hoedspruit with Phalaborwa. The route spans two provinces and passes through several private game reserves.
The R59 is a provincial route in South Africa that connects Hertzogville with Alberton via Bothaville, Parys and Vereeniging. The R59 is a freeway from the R57 Junction in Sasolburg until the N12 Reading Interchange in Alberton, signposted as the Sybrand van Niekerk Freeway.
The R104 is a regional route in South Africa that is the designation for some of the old sections of roads that were previously the N4, prior to upgrading. It connects Rustenburg in the North West province with Witbank in Mpumalanga province via Hartbeespoort, Mooinooi, Pretoria and Bronkhorstspruit. There is also a 50km section in Mpumalanga province connecting Middelburg and Wonderfontein.
The N12 is a national route in South Africa which runs from George through Beaufort West, Kimberley, Klerksdorp and Johannesburg to eMalahleni.
The N4 is a national route in South Africa that runs from Skilpadshek on the Botswana border, past Rustenburg, Pretoria, eMalahleni and Mbombela, to Komatipoort on the Mozambique border. It forms the South African section of the Trans-Kalahari Corridor, which runs from Walvis Bay to Maputo, meaning that it links the east and west coasts of Southern Africa.
The N11 is a national route in South Africa which runs from the Botswana border at Groblersbrug, through Mokopane, Middelburg, Ermelo and Newcastle to end at the N3 just after Ladysmith.
The N14 is a national route in South Africa which runs from Springbok in the Northern Cape to Pretoria in Gauteng. It passes through Upington, Kuruman, Vryburg, Krugersdorp and Centurion. The section between Pretoria and Krugersdorp is maintained by the Gauteng Provincial government and is also designated the P158.
The R101 is a Regional Route in South Africa that is the designation for some of the old sections of roads that were previously the N1, prior to upgrading. It only has 2 sections, from Bellville to Worcester and from Johannesburg to Polokwane.
The R511 is a Regional Route in South Africa that connects Sandton with Thabazimbi via Hartbeespoort and Brits.
The R545 is a Regional Route in Mpumalanga, South Africa that connects Balmoral with Bethal via Ogies and Kriel.
The R546 is a Regional Route in South Africa that connects Kinross with Vrede via Evander and Standerton.
The R547 is a Regional Route in Mpumalanga, South Africa.
The R555 is a Regional Route in South Africa that connects Springs with Ohrigstad via Delmas, Ogies, Witbank, Middelburg, Stoffberg and Burgersfort.
R35 near Bethal 
R547 near Thubelihle 
R542 near Vandyksdrif 
R575 
N12 near Witbank 
N4 in Witbank
R555 / R104 in Witbank
R25 near Verena
R573 near Kwaggafontein 
