CY-208,243

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CY-208,243
CY-208,243 Structure.svg
Identifiers
  • 4,6,6a,7,8,12b-hexahydro-7-methylindolo(4,3-ab)-phenanthridine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
Formula C19H18N2
Molar mass 274.367 g·mol−1
3D model (JSmol)
  • c15c4[nH]cc5CC2C(c1ccc4)c3ccccc3CN2C
  • InChI=1S/C19H18N2/c1-21-11-12-5-2-3-6-14(12)19-15-7-4-8-16-18(15)13(10-20-16)9-17(19)21/h2-8,10,17,19-20H,9,11H2,1H3/t17-,19-/m1/s1 X mark.svgN
  • Key:WRNKIDLXXXIELU-IEBWSBKVSA-N X mark.svgN
 X mark.svgNYes check.svgY  (what is this?)    (verify)

CY-208,243 is a drug which acts as a dopamine agonist selective for the D1 subtype. Unlike most D1-selective agonists, it shows efficacy in animal models of Parkinson's disease. [1] [2] [3] [4] [5]

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References

  1. Gagnon C, Gomez-Mancilla B, Markstein R, Bédard PJ, Di Paolo T (July 1995). "Effect of adding the D-1 agonist CY 208-243 to chronic bromocriptine treatment of MPTP-monkeys: regional changes of brain dopamine receptors". Progress in Neuro-psychopharmacology & Biological Psychiatry. 19 (4): 667–76. doi:10.1016/0278-5846(95)00110-h. PMID   8588064. S2CID   26670068.
  2. Beninger RJ, Rolfe NG (December 1995). "Dopamine D1-like receptor agonists impair responding for conditioned reward in rats". Behavioural Pharmacology. 6 (8): 785–793. doi:10.1097/00008877-199512000-00003. PMID   11224381. S2CID   23656469.
  3. Luquin MR, Guillén J, Legarda I, Cruz Rodriguez M, Del Rio L, Dominguez J, Martínez-Lage JM (1996). "Pulsatile administration of D1 but not D2 dopamine agonists induces behavioral tolerance in MPTP-treated monkeys". Advances in Neurology. 69: 239–44. PMID   8615134.
  4. D'Aquila PS, Panin F, Cossu M, Peana AT, Serra G (January 2003). "Dopamine D1 receptor agonists induce penile erections in rats". European Journal of Pharmacology. 460 (1): 71–4. doi:10.1016/S0014-2999(02)02881-9. PMID   12535862.
  5. Salamone JD, Carlson BB, Rios C, Lentini E, Correa M, Wisniecki A, Betz A (January 2005). "Dopamine agonists suppress cholinomimetic-induced tremulous jaw movements in an animal model of Parkinsonism: tremorolytic effects of pergolide, ropinirole and CY 208-243". Behavioural Brain Research. 156 (2): 173–9. doi:10.1016/j.bbr.2004.05.019. PMID   15582103. S2CID   10255277.