MRPS6

MRPS6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Identifiers
Aliases	MRPS6 , C21orf101, MRP-S6, RPMS6, S6mt, mitochondrial ribosomal protein S6
External IDs	OMIM: 611973 MGI: 2153111 HomoloGene: 41871 GeneCards: MRPS6
Gene location (Human) Chr. Chromosome 21 (human) [1] Band 21q22.11 Start 34,073,224 bp [1] End 34,143,034 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 C4 Start 91,855,158 bp [2] End 91,909,115 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla left lobe of thyroid gland kidney right lobe of thyroid gland right coronary artery tibial nerve spinal ganglia trigeminal ganglion ascending aorta Achilles tendon Top expressed in retinal pigment epithelium ciliary body medullary collecting duct sciatic nerve iris renal corpuscle condyle calvaria fossa white adipose tissue More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome rRNA binding protein binding small ribosomal subunit rRNA binding Cellular component small ribosomal subunit mitochondrial inner membrane ribosome mitochondrial small ribosomal subunit mitochondrion Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis mitochondrial translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64968 121022 Ensembl ENSG00000243927 ENSMUSG00000039680 UniProt P82932 P58064 RefSeq (mRNA) NM_032476 NM_080456 RefSeq (protein) NP_115865 NP_536704 Location (UCSC) Chr 21: 34.07 – 34.14 Mb Chr 16: 91.86 – 91.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

28S ribosomal protein S6, mitochondrial is a protein that in humans is encoded by the MRPS6 gene. ^[5]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000243927 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039680 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: MRPS6 mitochondrial ribosomal protein S6".

Further reading

• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi: 10.1038/35012518 . PMID   10830953.
• Cavdar Koc E, Burkhart W, Blackburn K, et al. (2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J. Biol. Chem. 276 (22): 19363–74. CiteSeerX   10.1.1.501.8919 . doi: 10.1074/jbc.M100727200 . PMID   11279123.
• Suzuki T, Terasaki M, Takemoto-Hori C, et al. (2001). "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit". J. Biol. Chem. 276 (35): 33181–95. doi: 10.1074/jbc.M103236200 . PMID   11402041.
• Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID   11543634.
• Reymond A, Camargo AA, Deutsch S, et al. (2002). "Nineteen additional unpredicted transcripts from human chromosome 21". Genomics. 79 (6): 824–32. doi:10.1006/geno.2002.6781. PMID   12036297.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID   12706105.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.

External links

• Overview of all the structural information available in the PDB for UniProt : P82932 (28S ribosomal protein S6, mitochondrial) at the PDBe-KB .