National Institutes of Health Clinical Center

Last updated
National Institutes of Health (NIH) Clinical Center
NIH Clinical Research Center aerial.jpg
Aerial photo of the NIH Mark O. Hatfield Clinical Research Center, Bethesda, Maryland
Agency overview
Formed1953 (1953)
JurisdictionUnited States
Headquarters Bethesda, Maryland, U.S.
39°0′6″N77°6′16″W / 39.00167°N 77.10444°W / 39.00167; -77.10444
Agency executive
Parent agency National Institutes of Health, Department of Health & Human Services
Website www.cc.nih.gov

The NIH Clinical Center is a hospital solely dedicated to clinical research at the National Institutes of Health campus in Bethesda, Maryland. The Clinical Center, known as Building 10, consists of the original part of the hospital, the Warren Grant Magnuson Clinical Center, and the newest addition, the Mark O. Hatfield Clinical Research Center. The two parts are connected to form one large building. [1]

Contents

Since the hospital's opening in 1953, [2] NIH scientists have worked with volunteer patients to create medical innovations. Clinical Center successes include pioneering the cure of cancerous solid tumors with chemotherapy; the use of nitroglycerin to treat heart attacks; identifying a genetic component in schizophrenia; conducting the first successful replacement of a mitral valve to treat heart disease; and the creation of blood tests to identify both Acquired Immune Deficiency Syndrome (AIDS) and hepatitis. [3]

In October 2014, Clinical Center staff successfully treated one of the first few Ebola virus cases in the United States.

The Clinical Center has been a leader in the “bench-to-bedside” concept. Its specialized hospital design places patient care units in close proximity to research laboratories. This model supports interaction and collaboration among clinical researchers.

The Clinical Center also provides training opportunities for students, new and mid-career professionals. [4] A Summer Internship Program offers internships to students who are currently enrolled in high school, college, graduate programs and health professional schools such as nursing or medicine. [5] The Medical Research Scholars Program is a year-long research enrichment program designed for research-oriented medical, dental and veterinary students. [6] The Clinical Research Management Sabbatical is a self-directed educational experience designed for clinical research investigators and managers of clinical research programs. [7] The Clinical Center also provides a course called the Introduction to the Principles and Practice of Clinical Research to train physicians, scientists, medical students, nurses and other health professionals how to effectively conduct clinical research. [8]

History

The Warren Grant Magnuson Clinical Center opened in 1953 and is 13 floors at its highest point. It is named after Senator Warren Magnuson of Washington.

The Mark O. Hatfield Clinical Research Center, located at the north end of the Clinical Center, opened in 2005. It was named after Senator Mark Hatfield of Oregon. [9]

The hospital has 200 inpatient beds, 11 operating rooms, 93 day hospital stations, critical care services and research labs, an ambulatory care research facility and a complex array of imaging services. The Clinical Center is also one of the few facilities in the world with state-of-the-art infrastructure that allows for isolation capabilities and infection control while patients participate in clinical research studies. [1] [10]

Patients at the Clinical Center consent to participate in research studies, also called protocols, and are treated without charge. Admission is selective: only those patients who have a medical condition being studied by NIH Institutes or Centers and who meet the specific inclusion criteria can enroll in the studies.

In 2014, there were 1,611 clinical research studies underway at the Clinical Center including those focused on cancer, infectious diseases, blood disorders, heart disease, lung disease, alcoholism and drug abuse. [1]

More than 500,000 patients from all 50 states, and from countries around the world, have participated in clinical research at the Clinical Center. [1]

John I. Gallin served as director of the Clinical Center beginning in May 1994. In January 2017, as part of an update to the hospital's leadership structure, NIH director Francis S. Collins named James K. Gilman to the newly created position of chief executive officer Clinical Center. With the arrival of Gilman, Gallin assumed new roles as the NIH Associate Director for Clinical Research and Chief Scientific Officer, Clinical Center. [11]

Directors

Past directors 1948 - present [12]

PortraitDirectorTook officeLeft office
Jack Masur.jpg Jack Masur19481951
John A. Trautman.jpg John A. Trautman19511954
Donald W. Patrick.jpg Donald W. Patrick19541956
Jack Masur.jpg Jack Masur19561969
Thomas C. Chalmers.jpg Thomas C. Chalmers 19701973
Robert S. Gordon, Jr. (26372348656).jpg Robert S. Gordon, Jr.19741975
Mortimer B. Lipsett.jpg Mortimer B. Lipsett19761982
John L. Decker.jpg John L. Decker19831990
Acting CC Director Saul Rosen.jpg Saul Rosen (acting)19901994
Dr John I Gallin NIH 2010.jpg John I. Gallin 19942017
Dr. James K. Gilman.jpg James K. Gilman 2017present

Clinical trials

South entrance NIH Clinical Center South Entrance.jpg
South entrance

In 2014, the NIH Clinical Center had 1,611 active research protocols. 48% of those were clinical trials (773 protocols), another 46% were natural history studies (744 protocols) and the remaining 6% were screening and training protocols. [13]

The Clinical Center provides an environment for both patient care and conducting clinical trials, most of which are in Phase I or Phase II. [1] In 2014, of the 773 active clinical trials protocols, 23% were Phase I trials (261 protocols), 60% were Phase II trials (462 protocols), 5% were Phase III (39 protocols) and 3% were Phase IV (11 protocols). [13]

The Clinical Center also integrates data from all intramural clinical trials in an integrated data repository called Biomedical Translational Research Information System (BTRIS). [14]

Documentary

The Discovery Channel documentary First In Human: The Trials of Building 10, hosted by Jim Parsons, aired in August 2017. [15] The three-episode documentary showed experiences of some staff, patients and caregivers at the NIH Clinical Center.

Related Research Articles

<span class="mw-page-title-main">National Institutes of Health</span> US government medical research agency

The National Institutes of Health, commonly referred to as NIH, is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late 1880s and is now part of the United States Department of Health and Human Services. Many NIH facilities are located in Bethesda, Maryland, and other nearby suburbs of the Washington metropolitan area, with other primary facilities in the Research Triangle Park in North Carolina and smaller satellite facilities located around the United States. The NIH conducts its own scientific research through the NIH Intramural Research Program (IRP) and provides major biomedical research funding to non-NIH research facilities through its Extramural Research Program.

<span class="mw-page-title-main">Albert Einstein College of Medicine</span> Private medical school in New York City, New York

The Albert Einstein College of Medicine is a private, nonprofit, research-intensive medical school in the Morris Park neighborhood of the Bronx, New York City, United States. Founded in 1953, Einstein operates as an independent degree-granting institution as part of the integrated health care Montefiore Health System and also has affiliation with Jacobi Medical Center.

<span class="mw-page-title-main">Health informatics</span> Computational approaches to health care

Health informatics is the field of science and engineering that aims at developing methods and technologies for the acquisition, processing, and study of patient data, which can come from different sources and modalities, such as electronic health records, diagnostic test results, medical scans. The health domain provides an extremely wide variety of problems that can be tackled using computational techniques.

<span class="mw-page-title-main">Cedars-Sinai Medical Center</span> Hospital in California, United States

Cedars-Sinai Medical Center is a nonprofit, tertiary, 886-bed teaching hospital and multi-specialty academic health science center located in Los Angeles, California. Part of the Cedars-Sinai Health System, the hospital has a staff of over 2,000 physicians and 10,000 employees, supported by a team of 2,000 volunteers and more than 40 community groups. As of 2022-23, U.S. News & World Report ranked Cedars-Sinai among the top performing hospitals in the western United States. Cedars-Sinai is a teaching hospital affiliate of David Geffen School of Medicine at the University of California, Los Angeles (UCLA), which was ranked in the top 20 on the U.S. News 2023 Best Medical Schools: Research.

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) is one of the institutes and centers that make up the National Institutes of Health, an agency of the United States Department of Health and Human Services (HHS).

The Virginia–Maryland College of Veterinary Medicine is a state-supported college of two states, Virginia and Maryland, filling the need for veterinary medicine education in both states. Students from both states are considered "in-state" students for admissions purposes.

<span class="mw-page-title-main">Icahn School of Medicine at Mount Sinai</span> American medical school

The Icahn School of Medicine at Mount Sinai, formerly the Mount Sinai School of Medicine, is a private medical school in New York City, New York, United States. The school is the academic teaching arm of the Mount Sinai Health System, which manages eight hospital campuses in the New York metropolitan area, including Mount Sinai Hospital and the New York Eye and Ear Infirmary.

The Duke University School of Medicine, commonly known as Duke Med, is the medical school of Duke University. It is located in the Collegiate Gothic-style West Campus of Duke University in Durham, North Carolina. The School of Medicine, along with the Duke University School of Nursing, Duke University Hospital, Duke Regional Hospital, Duke Children's Hospital, Duke Raleigh Hospital, and other affiliated hospitals, clinics, and laboratories, make up the Duke University Health System. Established in 1925 by James B. Duke, the School of Medicine has earned its reputation as an integral part of one of the world's foremost patient care and biomedical research institutions.

<span class="mw-page-title-main">University of Virginia School of Medicine</span>

The University of Virginia School of Medicine is the graduate medical school of the University of Virginia. The school's facilities are on the University of Virginia grounds adjacent to Academical Village in Charlottesville, Virginia. Founded in 1819 by Thomas Jefferson, UVA SoM is the tenth oldest medical school in the United States, and is ranked 31st in research-oriented medical schools by U.S. News & World Report, and as of 2021, is ranked nineteenth in the nation in primary care. The School of Medicine confers Doctor of Medicine (M.D.) and Doctor of Philosophy (PhD) degrees, and is closely associated with both the University of Virginia Health System and Inova Health System.

Wake Forest University School of Medicine is the medical school of Wake Forest University, with two campuses located in Winston-Salem, North Carolina and Charlotte, North Carolina, United States. It is affiliated with Atrium Health Wake Forest Baptist, the academic medical center whose clinical arm is Atrium Health Wake Forest Baptist. In 2021, U.S. News & World Report ranked Wake Forest School of Medicine 48th best for research in the nation and 80th best for primary care. The School of Medicine also ranks in the top third of U.S. medical schools in funding from the National Institutes of Health (NIH).

<span class="mw-page-title-main">Susan Shurin</span>

Susan Shurin is a senior adviser at the National Cancer Institute. From 2006–2014, she served as Deputy and Acting Director of the National Heart, Lung, and Blood Institute (NHLBI) [NHLBI.nih.gov] at the National Institutes of Health [nih.gov] (NIH).

<span class="mw-page-title-main">James K. Gilman</span> United States Army general

James K. Gilman, a retired United States Army Major General and physician from Hymera, Indiana, became the first chief executive officer of the NIH Clinical Center Jan. 9, 2017. The NIH Clinical Center is the nation's largest hospital devoted to clinical research.

<span class="mw-page-title-main">Renaissance School of Medicine at Stony Brook University</span> Medical school of Stony Brook University

The Renaissance School of Medicine (RSOM) is the graduate medical school of Stony Brook University located in the hamlet of Stony Brook, New York on Long Island. Founded in 1971, RSOM is consistently ranked the top public medical school in New York according to U.S. News & World Report. RSOM is one of the five Health Sciences schools under the Stony Brook Medicine healthcare system.

<span class="mw-page-title-main">NIH Intramural Research Program</span> Internal research program of the National Institutes of Health

The NIH Intramural Research Program (IRP) is the internal research program of the National Institutes of Health (NIH), known for its synergistic approach to biomedical science. With 1,200 Principal Investigators and over 4,000 Postdoctoral Fellows conducting basic, translational, and clinical research, the NIH Intramural Research Program is the largest biomedical research institution on earth. The unique funding environment of the IRP facilitates opportunities to conduct both long-term and high-impact science that would otherwise be difficult to undertake. With rigorous external reviews ensuring that only the most outstanding research secures funding, the IRP is responsible for many scientific accomplishments, including the discovery of fluoride to prevent tooth decay, the use of lithium to manage bipolar disorder, and the creation of vaccines against hepatitis, Hemophilus influenzae (Hib), and human papillomavirus (HPV). In addition, the IRP has also produced or trained 21 Nobel Prize-winning scientists.

<span class="mw-page-title-main">Foundation for the National Institutes of Health</span>

The Foundation for the National Institutes of Health (FNIH) is a not-for-profit, 501(c)(3) charitable organization established by the US Congress in 1990. Located in North Bethesda, MD, the FNIH raises private-sector funds, and creates and manages alliances with public and private institutions in support of the mission of the National Institutes of Health (NIH).

The National Institutes of Health Clinical Research Training Program (CRTP) was a one-year education program aimed at highly qualified, research-oriented medical and dental students wanting to learn the theory and practice of clinical and translational research that ran from 1997 to 2012. It covered among other topics clinical research design, data analysis, bioethics, and critical review of the medical literature; but most of each fellow's time was devoted to conducting supervised clinical or translational research in their area of interest.

<span class="mw-page-title-main">Judith Vaitukaitis</span> Reproductive neuroendocrinologist

Judith L. Vaitukaitis was a reproductive neuroendocrinologist and clinical researcher who played a key role in developing a biochemical assay in the early 1970s that ultimately led to the creation of the home pregnancy test. She served for 12 years as director of the US National Center for Research Resources (NCRR) at the US National Institutes of Health (NIH).

<span class="mw-page-title-main">John I. Gallin</span> American medical researcher

John I. Gallin is an American medical researcher who has contributed to the understanding of innate immunity but especially chronic granulomatous disease, a phagocyte disorder. Gallin was appointed director of the NIH Clinical Center on May 1, 1994, and served until January 8, 2017. He serves as the chief scientific officer for the Clinical Center and associate director for clinical research at the National Institutes of Health.

<span class="mw-page-title-main">Gerald T. Keusch</span> American physician-scientist

Gerald T. Keusch is an American physician-scientist and academic administrator. Keusch is the associate provost for global health at Boston University Medical Campus and a professor of international health and medicine at Boston University School of Public Health. He was the director of John E. Fogarty International Center and the associate director of international research at the National Institutes of Health from 1998 to 2003.

<span class="mw-page-title-main">Janine Austin Clayton</span> American ophthalmologist

Janine Austin Clayton is an American ophthalmologist. She is the NIH associate director for research on women's health and director of the Office of Women's Health. Clayton was previously the deputy clinical director of the National Eye Institute.

References

  1. 1 2 3 4 5 "No Other Hospital". NIH Clinical Center. Retrieved February 1, 2015.
  2. "Beacon of Hope" (PDF). Office of History, National Institutes of Health. Retrieved February 1, 2015.
  3. "Accomplishments at America's clinical research hospital". NIH Clinical Newsletter. October 2011. Retrieved April 15, 2015.
  4. "Office of Clinical Research Training and Medical Education 2014 Annual Report" (PDF). Office of Clinical Research Training and Medical Education, NIH Clinical Center. 2014. Retrieved February 1, 2015.
  5. "Summer Internship Program". Office of Clinical Research Training and Medical Education, NIH Clinical Center. Retrieved February 1, 2015.
  6. "Medical Research Scholars Program". Office of Clinical Research Training and Medical Education, NIH Clinical Center. Retrieved February 1, 2015.
  7. "Clinical Research Management Sabbatical". Office of Clinical Research Training and Medical Education, NIH Clinical Center. Retrieved February 1, 2015.
  8. "Introduction to the Principles and Practice of Clinical Research". Office of Clinical Research Training and Medical Education, NIH Clinical Center. Retrieved February 1, 2015.
  9. "Research center named for ex-Oregon senator". The Seattle Times. September 23, 2004. Retrieved April 15, 2015.
  10. "Facts at a Glance". NIH Clinical Center. Retrieved February 1, 2015.
  11. "Major General James Gilman, M.D., tapped to lead NIH Clinical Center". NIH. December 2016. Retrieved January 4, 2017.
  12. "Clinical Center Directors". www.nih.gov.
  13. 1 2 "NIH Clinical Center Director's Annual Report 2015" (PDF). NIH Clinical Center. 2015. Retrieved February 1, 2015.
  14. Cimino, J. J.; Ayres, E. J.; Remennik, L.; Rath, S.; Freedman, R.; Beri, A.; Chen, Y.; Huser, V. (2013). "The National Institutes of Health's Biomedical Translational Research Information System (BTRIS): Design, contents, functionality and experience to date". Journal of Biomedical Informatics. 52: 11–27. doi:10.1016/j.jbi.2013.11.004. PMC   4026354 . PMID   24262893.
  15. "Discovery: First in Human". Discovery Impact. Retrieved August 19, 2017.

Further reading