TPTE

TPTE
Identifiers
Aliases	TPTE , CT44, PTEN2, transmembrane phosphatase with tensin homology
External IDs	OMIM: 604336 GeneCards: TPTE
Gene location (Human)
Chr.	Chromosome 21 (human)
End	10,606,140 bp
RNA expression pattern
	Top expressed in
	placenta; ; renal cortex; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; body of stomach; ; anterior pituitary; ; blood; ; human musculoskeletal system; ; muscle; ; gallbladder;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein tyrosine phosphatase activity ; phosphoprotein phosphatase activity ; hydrolase activity ; protein tyrosine/serine/threonine phosphatase activity ;
Cellular component	integral component of membrane ; membrane ;
Biological process	signal transduction ; dephosphorylation ; peptidyl-tyrosine dephosphorylation ; protein dephosphorylation ;
	Sources:Amigo / QuickGO
Orthologs
	7179
	n/a
	ENSG00000274391
	n/a
	P56180
	n/a
	NM_199261 ; NM_001290224 ; NM_199259 ; NM_199260
	n/a
	NP_001277153 ; NP_954868 ; NP_954869 ; NP_954870
	n/a
	Wikidata
View/Edit Human

Last updated October 19, 2023

Putative tyrosine-protein phosphatase TPTE is an enzyme that in humans is encoded by the TPTE gene.^[3]^[4]

Function

TPTE is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids.^[4] TPTE is a primate-specific duplicate of the TPTE2 (TPIP) inositol phospholipid phosphatase;^[5] TPTE itself is predicted to lack phosphatase activity.^[6] TPTE and TPTE2 are the mammalian homologues to the subfamily of voltage sensitive phosphatases.

Related Research Articles

<i>PTEN</i> (gene) Tumor suppressor gene

Phosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the PTEN gene. Mutations of this gene are a step in the development of many cancers, specifically glioblastoma, lung cancer, breast cancer, and prostate cancer. Genes corresponding to PTEN (orthologs) have been identified in most mammals for which complete genome data are available.

Inositol polyphosphate 5-phosphatase OCRL-1, also known as Lowe oculocerebrorenal syndrome protein, is an enzyme encoded by the OCRL gene located on the X chromosome in humans.

Glucose-6-phosphatase, catalytic subunit is an enzyme that in humans is encoded by the G6PC gene.

Receptor-type tyrosine-protein phosphatase F is an enzyme that, in humans, is encoded by the PTPRF gene.

Dual specificity tyrosine-phosphorylation-regulated kinase 1A is an enzyme that in humans is encoded by the DYRK1A gene. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.

Exostosin-1 is a protein that in humans is encoded by the EXT1 gene.

Myotubularin is a protein that in humans is encoded by the MTM1 gene.

Receptor-type tyrosine-protein phosphatase zeta also known as phosphacan is an enzyme that in humans is encoded by the PTPRZ1 gene.

Deleted in azoospermia protein 3 is a protein that in humans is encoded by the DAZ3 gene.

Protein tyrosine phosphatase type IVA 2 is an enzyme that in humans is encoded by the PTP4A2 gene.

Transmembrane protease, serine 3 is an enzyme that in humans is encoded by the TMPRSS3 gene.

Receptor-type tyrosine-protein phosphatase delta is an enzyme that, in humans, is encoded by the PTPRD gene.

Leukocyte receptor tyrosine kinase is an enzyme that in humans is encoded by the LTK gene.

Receptor-type tyrosine-protein phosphatase gamma is an enzyme that in humans is encoded by the PTPRG gene.

Protein CLN8 is a protein that in humans is encoded by the CLN8 gene.

Myotubularin-related protein 2 also known as phosphatidylinositol-3,5-bisphosphate 3-phosphatase or phosphatidylinositol-3-phosphate phosphatase is a protein that in humans is encoded by the MTMR2 gene.

Multiple inositol polyphosphate phosphatase 1 is an enzyme that in humans is encoded by the MINPP1 gene.

Serine/threonine-protein kinase DCLK1 is an enzyme that in humans is encoded by the DCLK1 gene.

Cysteine and tyrosine-rich protein 1 is a protein that in humans is encoded by the CYYR1 gene and is located on chromosome 21, location 21q21.2. This protein has a function that is not presently understood.

Voltage sensitive phosphatases or voltage sensor-containing phosphatases, commonly abbreviated VSPs, are a protein family found in many species, including humans, mice, zebrafish, frogs, and sea squirt.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000274391 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tapparel C, Reymond A, Girardet C, Guillou L, Lyle R, Lamon C, Hutter P, Antonarakis SE (Dec 2003). "The TPTE gene family: cellular expression, subcellular localization and alternative splicing". Gene. 323: 189–99. doi:10.1016/j.gene.2003.09.038. PMID 14659893.
1 2 "Entrez Gene: TPTE transmembrane phosphatase with tensin homology".
↑ Leslie NR, Yang X, Downes CP, Weijer CJ (January 2007). "PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration". Curr. Biol. 17 (2): 115–25. doi:10.1016/j.cub.2006.12.026. PMC 1885949 . PMID 17240336.
↑ Chen, Mark J.; Dixon, Jack E.; Manning, Gerard (2017-04-11). "Genomics and evolution of protein phosphatases". Sci. Signal. 10 (474): eaag1796. doi:10.1126/scisignal.aag1796. ISSN 1945-0877. PMID 28400531. S2CID 41041971.

Antonarakis SE (1998). "10 years of Genomics, chromosome 21, and Down syndrome". Genomics. 51 (1): 1–16. doi:10.1006/geno.1998.5335. PMID 9693027.
Chen H, Rossier C, Morris MA, et al. (2000). "A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y.". Hum. Genet. 105 (5): 399–409. doi:10.1007/s004390051122. PMID 10598804.
Guipponi M, Yaspo ML, Riesselman L, et al. (2000). "Genomic structure of a copy of the human TPTE gene which encompasses 87 kb on the short arm of chromosome 21" (PDF). Hum. Genet. 107 (2): 127–31. doi:10.1007/s004390000343. PMID 11030409. S2CID 29304641.
Wu Y, Dowbenko D, Pisabarro MT, et al. (2001). "PTEN 2, a Golgi-associated testis-specific homologue of the PTEN tumor suppressor lipid phosphatase". J. Biol. Chem. 276 (24): 21745–53. doi: 10.1074/jbc.M101480200 . PMID 11279206.
Guipponi M, Tapparel C, Jousson O, et al. (2002). "The murine orthologue of the Golgi-localized TPTE protein provides clues to the evolutionary history of the human TPTE gene family" (PDF). Hum. Genet. 109 (6): 569–75. doi:10.1007/s004390100607. PMID 11810268. S2CID 8267495.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000274391 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14659893-3] Tapparel C, Reymond A, Girardet C, Guillou L, Lyle R, Lamon C, Hutter P, Antonarakis SE (Dec 2003). "The TPTE gene family: cellular expression, subcellular localization and alternative splicing". Gene. 323: 189–99. doi:10.1016/j.gene.2003.09.038. PMID 14659893.

[entrez-4] 1 2 "Entrez Gene: TPTE transmembrane phosphatase with tensin homology".

[pmid17240336-5] Leslie NR, Yang X, Downes CP, Weijer CJ (January 2007). "PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration". Curr. Biol. 17 (2): 115–25. doi:10.1016/j.cub.2006.12.026. PMC 1885949 . PMID 17240336.

[6] Chen, Mark J.; Dixon, Jack E.; Manning, Gerard (2017-04-11). "Genomics and evolution of protein phosphatases". Sci. Signal. 10 (474): eaag1796. doi:10.1126/scisignal.aag1796. ISSN 1945-0877. PMID 28400531. S2CID 41041971.

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TPTE

Contents

Function

Related Research Articles

References

Further reading