U.S. Route 14 or U.S. Highway 14 (US 14), an east–west route, is one of the original United States Numbered Highways of 1926. It currently has a length of about 1,445 miles (2,326 km), for much of which it runs roughly parallel to Interstate 90 (I-90).
U.S. Route 81 or U.S. Highway 81 (US 81) is a major north–south U.S. highway that extends for 1,220 miles (1,960 km) in the central United States and is one of the original United States Numbered Highways established in 1926 by the American Association of State Highway Officials.
U.S. Route 271 is a north–south United States highway. Never a long highway, it went from bi-state route to a tri-state route. Its southern terminus is in Tyler, Texas, at an intersection with State Highway 31 and SH 155. The highway's northern terminus is in Fort Smith, Arkansas, at an intersection with Business U.S. Route 71 and Highway 255. It enters Arkansas from Oklahoma as a controlled-access highway, but the highway continues as Interstate 540 when US 271 exits toward downtown after one-half mile (800 m) in Arkansas.
U.S. Route 11 or U.S. Highway 11 (US 11) is a major north–south United States Numbered Highway extending 1,645 miles (2,647 km) across the eastern U.S. The southern terminus of the route is at US 90 in Bayou Sauvage National Wildlife Refuge in eastern New Orleans, Louisiana. The northern terminus is at the Rouses Point–Lacolle 223 Border Crossing in Rouses Point, New York. The route continues across the border into Canada as Route 223. US 11, created in 1926, maintains most of its original route. The route north of Knoxville, Tennessee, follows a route similar to Interstate 81 (I-81). While it is signed as a north–south route, it physically travels in a northeast–southwest direction.
U.S. Route 52 (US 52) is a major United States highway in the central United States that extends from the northern to southeastern region of the United States. Contrary to most other even-numbered U.S. Highways, US 52 primarily follows a northwest–southeast route, and is signed north–south or east–west depending on the local orientation of the route. The highway's northwestern terminus is in Portal, North Dakota at the Canada–United States border, where it continues as Saskatchewan Highway 39. Its southeastern terminus is in Charleston, South Carolina, at Number 2 Meeting Street and White Point Garden along the Charleston Harbor.
U.S. Route 83 (US 83) is a major north–south United States Numbered Highway that extends 1,885 miles (3,034 km) in the central United States. Only four other north–south routes are longer: US 1, US 41, US 59, and US 87, while US 83 follows a straighter north-south path than all of these. Nearly half of its mileage is in the state of Texas. The highway's northern terminus is north of Westhope, North Dakota, at the Canadian border, where it continues as Manitoba Highway 83 (PTH 83). The southern terminus is at the Veterans International Bridge in Brownsville, Texas. Together, US 83 and PTH 83 form a continuously numbered north-south highway with a combined distance of 3,450 kilometres (2,140 mi).
U.S. Route 183 (US 183) is a north–south United States highway. The highway's northern terminus is in Presho, South Dakota, at an intersection with Interstate 90. Its southern terminus is in Refugio, Texas, at the southern intersection of U.S. Highway 77 and Alternate US 77.
U.S. Route 54 is an east–west United States Highway that runs northeast–southwest for 1,197 miles (1,926 km) from El Paso, Texas, to Griggsville, Illinois. The Union Pacific Railroad's Tucumcari Line runs parallel to US 54 from El Paso to Pratt, Kansas, which comprises about two-thirds of the route.
U.S. Route 85 (US 85) is a 1,479-mile-long (2,380 km) north–south United States Highway that travels in the Mountain and Northern Plains states of the United States. The southern terminus of the highway is at the Mexican border in El Paso, Texas, connecting with Mexican Federal Highway 45. The northern terminus is at the Canadian border in Fortuna, North Dakota, where the route continues north as Saskatchewan Highway 35. The highway route is part of the CanAm Highway. Sections of US 85 are designated as the Theodore Roosevelt Expressway.
U.S. Route 385 (US 385) is a spur of U.S. Route 85 that runs for 1,206 miles (1,941 km) from Deadwood, South Dakota to Big Bend National Park in Texas.
Pennsylvania Route 309 is a state highway that runs for 134 miles (216 km) through eastern Pennsylvania. The route runs from an interchange between PA 611 and Cheltenham Avenue on the border of Philadelphia and Cheltenham Township north to an intersection with PA 29 in Bowman Creek, a village in Monroe Township in Wyoming County. The highway connects Philadelphia and its northern suburbs to Allentown and the Lehigh Valley, and Hazleton and Wilkes-Barre in Wyoming Valley.
State Road 1 (SR 1) is a north–south state highway in eastern Indiana, consisting of two segments. Its southern segment begins at U.S. Highway 50 and Interstate 275 in east-central Dearborn County, just east of Lawrenceburg, and ends at Interstate 469 south of Fort Wayne. Its northern segment begins at Interstate 69 on Fort Wayne's north side, and ends at U.S. Route 20 in east-central Steuben County, approximately 6 miles (9.7 km) east of Angola.
Interstate 78 (I-78) is a major east–west Interstate Highway stretching from Union Township, Lebanon County, Pennsylvania, in the west to the Holland Tunnel and New York City in the east. In Pennsylvania, I-78 runs for about 78 miles (126 km) from the western terminus at I-81 in Union Township east to the New Jersey state line near Easton in Northampton County.
U.S. Route 322 is a spur of US 22, running from Cleveland, Ohio, east to Atlantic City, New Jersey. In the U.S. state of Pennsylvania, the route runs from the Ohio state line in West Shenango Township southeast to the Commodore Barry Bridge over the Delaware River in Chester, at which point the route crosses into New Jersey. The route passes near or through several cities, including Meadville, DuBois, State College, and Harrisburg. US 322 in Pennsylvania is named the 28th Division Highway in honor of the 28th Infantry Division.
Interstate 29 (I-29) is a north–south Interstate Highway in the midwestern United States. In the state of South Dakota, I-29 traverses on the eastern side of the state from the Iowa border near Sioux City to the North Dakota border near New Effington. On its route, I-29 passes through western portions of Sioux Falls, the state's largest city. It travels 252.5 miles (406.4 km) in the state, the longest stretch of any of the four states through which it passes. I-229, the highway's lone auxiliary route in South Dakota, serves as a bypass around southern and eastern Sioux Falls.
Interstate 90 (I-90) in the US state of South Dakota traverses east–west through the southern half of the state.
Interstate 90 Business may refer to several business routes of the Interstate Highway System that connects Interstate 90 with the central business district of various cities bypassed by I-90. Each business route can be either a business loop or a business spur, depending on whether both ends connect to I-90. The business route in each community is considered a unique route. In many cases, these routes are a former section of a U.S. Route.
Farm to Market Road 157 is a Farm to Market Road in the US state of Texas, traveling from an exit on Texas State Highway 121 south, through Euless, Bedford, Fort Worth, and Arlington in Tarrant County, then enters Johnson County, and passes through Mansfield, and Venus, before entering Ellis County, and terminating at an intersection with Farm to Market Road 66 in Maypearl. While located in Euless and Bedford, FM 157 is known as Industrial Boulevard, while in Fort Worth, it is known as Collins Street. In Arlington, the route continues on North Collins, Division, and South Cooper Streets. In Mansfield, the road is known as Main Street and Lone Star Road; in Venus as Main, 8th & 7th Streets; and in Maypearl as Highway 157. The highway passes directly through the center of Euless and Bedford, passing large neighborhoods and businesses. The route passes a large wetland before passing directly through downtown Arlington, passing major attractions such as AT&T Stadium and Globe Life Field. The route passes through the center of the University of Texas at Arlington, and continues through downtown and southern Arlington, before entering Mansfield. The route continues through central Mansfield, and south to Maypearl. The Texas Department of Transportation (TxDOT) designated the route in 1945, and redesignated the portion traveling from SH 121 to US Bus. 287 as Urban Road 157 from 1995 until 2018.
At least 14 special routes of U.S. Route 14 (US 14) have existed.
U.S. Route 63 is the portion of a north-south highway that runs through the U.S. state of Missouri from the Arkansas state line near Thayer to the Iowa state line near Lancaster.
US 83 near Olsonville 
