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The 1963 Manchester Openshaw by-election was held on 5 December 1963. It was held due to the death of the incumbent Labour MP, W. R. Williams. The by-election was won by the Labour candidate Charles Morris.
| Party | Candidate | Votes | % | ±% | |
|---|---|---|---|---|---|
| Labour | Charles Morris | 16,101 | 65.9 | +5.7 | |
| Conservative | Gerald Fitzsimmons | 7,139 | 29.2 | −10.6 | |
| Communist | Eddie Marsden | 1,185 | 4.9 | New | |
| Majority | 8,962 | 36.7 | +16.4 | ||
| Turnout | 24,425 | ||||
| Labour hold | Swing | ||||
