2-APQC

2-APQC
Clinical data
Drug class	Sirtuin-3 (SIRT3) activator
Identifiers
	IUPAC name 2-amino-1-[(4-fluorophenyl)methyl]-N-pentylpyrrolo[3,2-b]quinoxaline-3-carboxamide;
CAS Number	500271-63-6 ;
PubChem CID	1965265 ;
ChemSpider	1499078 ;
Chemical and physical data
Formula	C23H24FN5O
Molar mass	405.477 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES CCCCCNC(=O)C1=C(N(C2=NC3=CC=CC=C3N=C12)CC4=CC=C(C=C4)F)N;
	InChI InChI=1S/C23H24FN5O/c1-2-3-6-13-26-23(30)19-20-22(28-18-8-5-4-7-17(18)27-20)29(21(19)25)14-15-9-11-16(24)12-10-15/h4-5,7-12H,2-3,6,13-14,25H2,1H3,(H,26,30); Key:FYNPHMNXVLLDAS-UHFFFAOYSA-N;

Last updated December 30, 2025

2-APQC is a drug which acts as a sirtuin-3 (SIRT3) activator. In animal studies, it improved muscle and heart function in aged mice.^[1]^[2]

References

↑ Peng F, Liao M, Jin W, Liu W, Li Z, Fan Z, et al. (May 2024). "2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis". Signal Transduction and Targeted Therapy. 9 (1) 133. doi:10.1038/s41392-024-01816-1. PMC 11094072 . PMID 38744811.
↑ Xu C, Xiong L, Chen J, Liu Q, Wang F, Fu X, et al. (2025). "Sirtuin 3 modulation by high phosphates: a potential mechanism in muscle aging and sarcopenia". American Journal of Translational Research. 17 (6): 4187–4197. doi:10.62347/JWEY8421. PMC 12261155 . PMID 40672597.

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[1] Peng F, Liao M, Jin W, Liu W, Li Z, Fan Z, et al. (May 2024). "2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis". Signal Transduction and Targeted Therapy. 9 (1) 133. doi:10.1038/s41392-024-01816-1. PMC 11094072 . PMID 38744811.

[2] Xu C, Xiong L, Chen J, Liu Q, Wang F, Fu X, et al. (2025). "Sirtuin 3 modulation by high phosphates: a potential mechanism in muscle aging and sarcopenia". American Journal of Translational Research. 17 (6): 4187–4197. doi:10.62347/JWEY8421. PMC 12261155 . PMID 40672597.

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