| Singles | |
|---|---|
| 2006 SAP Open | |
| Champion |  Andy Murray |
| Runner-up |  Lleyton Hewitt |
| Score | 2–6, 6–1, 7–6(7–3) |
| Draw | 32 (4Q / 3WC) |
| Seeds | 8 |
Andy Roddick was the defending champion, but lost in the semifinals to eventual champion Andy Murray.
Murray defeated Lleyton Hewitt 2–6, 6–1, 7–6(7–3), to become 2006 SAP Open Champion, and claim his first ever ATP Tour title.
Andy Roddick (semifinals) Andre Agassi (withdrew) Lleyton Hewitt (final)
Tommy Robredo (first round) James Blake (first round)
Victor Hănescu (withdrew)
Dmitry Tursunov (second round)
Ivo Karlović (first round)| Semifinals | Final | ||||||||||||
| 1 | Andy Roddick | 5 | 5 | ||||||||||
| Andy Murray | 7 | 7 | |||||||||||
| Andy Murray | 2 | 6 | 77 | ||||||||||
| 3 | Lleyton Hewitt | 6 | 1 | 63 | |||||||||
| 3 | Lleyton Hewitt | 6 | 6 | ||||||||||
| Vince Spadea | 3 | 4 | |||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | A Roddick | 6 | 6 | ||||||||||||||||||||||||
| G García López | 3 | 4 | 1 | A Roddick | 6 | 1 | 6 | ||||||||||||||||||||
 L Dlouhý | 6 | 2 | 1 |  K Carlsen | 3 | 6 | 3 | ||||||||||||||||||||
| K Carlsen | 3 | 6 | 6 | 1 | A Roddick | 6 | 6 | ||||||||||||||||||||
 C Saulnier | 4 | 5 |  B Phau | 3 | 2 | ||||||||||||||||||||||
| B Phau | 6 | 7 | B Phau | 7 | 7 | ||||||||||||||||||||||
| Q | B Wilson | 7 | 7 | Q | B Wilson | 5 | 5 | ||||||||||||||||||||
| 8 | I Karlović | 61 | 65 | 1 | A Roddick | 5 | 5 | ||||||||||||||||||||
| 4 | T Robredo | 6 | 5 | 5 | A Murray | 7 | 7 | ||||||||||||||||||||
| WC | M Philippoussis | 3 | 7 | 7 | WC | M Philippoussis | 2 | 3 | |||||||||||||||||||
| A Pavel | 3 | 4 |  R Söderling | 6 | 6 | ||||||||||||||||||||||
| R Söderling | 6 | 6 | R Söderling | 6 | 5 | 4 | |||||||||||||||||||||
| A Murray | 6 | 6 | A Murray | 4 | 7 | 6 | |||||||||||||||||||||
| WC | M Fish | 2 | 2 | A Murray | 6 | 6 | |||||||||||||||||||||
 W Yeu-tzuoo | 6 | 7 | W Yeu-tzuoo | 4 | 2 | ||||||||||||||||||||||
| 5 | J Blake | 3 | 5 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 7 | D Tursunov | 4 | 6 | 6 | |||||||||||||||||||||||
| J Björkman | 6 | 3 | 2 | 7 | D Tursunov | 3 | 7 | 3 | |||||||||||||||||||
| W Arthurs | 4 | 7 | 7 | W Arthurs | 6 | 65 | 6 | ||||||||||||||||||||
| B Reynolds | 6 | 5 | 5 | W Arthurs | 64 | 2 | |||||||||||||||||||||
| J Johansson | 3 | 6 | 3 | 3 | L Hewitt | 7 | 6 | ||||||||||||||||||||
| Q | S Warburg | 6 | 4 | 6 | Q | S Warburg | 4 | 3 | |||||||||||||||||||
| P Goldstein | 4 | 2 | 3 | L Hewitt | 6 | 6 | |||||||||||||||||||||
| 3 | L Hewitt | 6 | 6 | 3 | L Hewitt | 6 | 6 | ||||||||||||||||||||
| LL | B Rehnquist | 1 | 4 | V Spadea | 3 | 4 | |||||||||||||||||||||
| Q | J Gimelstob | 6 | 6 | Q | J Gimelstob | 61 | 6 | 2 | |||||||||||||||||||
| R Schüttler | 1 | 3 |  K Vliegen | 7 | 4 | 6 | |||||||||||||||||||||
| K Vliegen | 6 | 6 | K Vliegen | 1 | 6 | 3 | |||||||||||||||||||||
| Q | S Querrey | 7 | 4 | 2 | V Spadea | 6 | 2 | 6 | |||||||||||||||||||
| V Spadea | 64 | 6 | 6 | V Spadea | 6 | 6 | |||||||||||||||||||||
| WC | S Jenkins | 5 | 6 | 3 | LL | T Rettenmaier | 2 | 0 | |||||||||||||||||||
| LL | T Rettenmaier | 7 | 3 | 6 | |||||||||||||||||||||||
Defending champion Roger Federer defeated Andre Agassi in the final, 6–3, 2–6, 7–6(7–1), 6–1 to win the men's singles tennis title at the 2005 US Open. It was his second US Open title and sixth major title overall. This was Agassi's last appearance in a major final.
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Defending champion Lleyton Hewitt defeated Gustavo Kuerten in the final, 6–1, 6–1 to win the men's singles tennis title at the 2003 Indian Wells Masters.
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Roger Federer defeated Andy Roddick in the final, 6–3, 7–5 to win the men's singles tennis title at the 2005 Cincinnati Masters.
Lleyton Hewitt was the defending champion but lost in the quarterfinals to Sébastien Grosjean.
Andy Roddick was the defending champion and won in the final 7–6(9–7), 7–6(7–4) against Ivo Karlović.
Rafael Nadal was the defending champion, but chose not to participate due to a knee injury.
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Andy Roddick was the defending champion, but withdrew due to an Abdominal strain.
Lleyton Hewitt was the defending champion, but did not participate.
Andre Agassi was the defending champion, but lost in the quarterfinals this year.