Date Time Opponent Site TV Result Attendance August 31 3:30 pm Kentucky * ESPN L 2–2742,696 [ 3] September 6 3:30 pm Tennessee Tech * Papa John's Cardinal Stadium Louisville, Kentucky ESPN360 /WHAS W 51–1038,694 [ 3] September 17 8:00 pm Kansas State * Papa John's Cardinal Stadium Louisville, Kentucky ESPN2 W 38–2942,208 [ 3] September 26 8:00 pm Connecticut Papa John's Cardinal Stadium Louisville, Kentucky ESPN2 L 21–2642,523 [ 3] October 10 3:30 pm at Memphis * ESPN W 35–2840,248 [ 3] October 18 3:30 pm Middle Tennessee State * Papa John's Cardinal Stadium Louisville, Kentucky W 42–2338,319 [ 3] October 25 3:30 pm No. 14 South Florida Papa John's Cardinal Stadium Louisville, Kentucky ESPN360 W 24–2040,384 [ 3] November 1 7:05 pm at Syracuse ESPNU L 21–2832,917 [ 3] November 8 12:00 pm at No. 25 Pittsburgh ESPN360 L 7–4144,055 [ 3] November 14 8:00 pm No. 22 Cincinnati ESPN2 L 20–2837,822 [ 3] November 22 12:00 pm West Virginia Papa John's Cardinal Stadium Louisville, Kentucky ESPN L 21–3534,796 [ 3] December 4 7:30 pm at Rutgers ESPN L 14–6342,347 [ 3]