| Year | Team | Overall | Conference | Standing | Bowl/playoffs | Coaches# | AP° |
|---|
| Lester Larson (Independent)(1912–1913) |
| 1912 | Louisville | 3–1 | | | | | |
| 1913 | Louisville | 5–1 | | | | | |
| Bruce Baker(Independent)(1914) |
| 1914 | Louisville | 1–4 | | | | | |
| Will Duffy (Independent)(1915–1916) |
| 1915 | Louisville | 1–5–1 | | | | | |
| 1916 | Louisville | 2–3–1 | | | | | |
| 1917–20 | No team | | | | | | |
| Bill Duncan(Independent)(1921–1922) |
| 1921 | Louisville | 2–2–1 | | | | | |
| 1922 | Louisville | 2–7 | | | | | |
| Fred Enke (Independent)(1923–1924) |
| 1923 | Louisville | 5–3 | | | | | |
| 1924 | Louisville | 3–5–1 | | | | | |
| Tom King (Independent)(1925–1930) |
| 1925 | Louisville | 8–0 | | | | | |
| Tom King(Southern Intercollegiate Athletic Association)(1926–1930) |
| 1926 | Louisville | 6–2 | 2–1 | T–11th | | | |
| 1927 | Louisville | 4–4 | 2–2 | T–9th | | | |
| 1928 | Louisville | 1–7 | 0–4 | 29th | | | |
| 1929 | Louisville | 3–5 | 1–3 | T–22nd | | | |
| 1930 | Louisville | 5–3 | 2–2 | T–13th | | | |
| Jack McGrath (Southern Intercollegiate Athletic Association)(1931) |
| 1931 | Louisville | 0–8 | 0–5 | 32nd | | | |
| C. V. Money (Southern Intercollegiate Athletic Association)(1932) |
| 1932 | Louisville | 0–9 | 0–5 | 27th | | | |
| Ben Cregor (Southern Intercollegiate Athletic Association)(1933–1935) |
| 1933 | Louisville | 1–7 | 1–6 | 28th | | | |
| 1934 | Louisville | 2–5 | 2–3 | T–20th | | | |
| 1935 | Louisville | 1–6–1 | 1–4 | T–26th | | | |
| Laurie Apitz (Southern Intercollegiate Athletic Association)(1936–1941) |
| 1936 | Louisville | 4–4 | 2–3 | T–20th | | | |
| 1937 | Louisville | 2–5–1 | 1–3–1 | T–23rd | | | |
| 1938 | Louisville | 2–6 | 0–3 | T–29th | | | |
| 1939 | Louisville | 5–2–1 | 1–1–1 | T–14th | | | |
| 1940 | Louisville | 3–5–1 | 0–2 | T–28th | | | |
| 1941 | Louisville | 4–4 | 1–1 | T–14th | | | |
| Laurie Apitz(Independent)(1942) |
| 1942 | Louisville | 2–3 | | | | | |
| 1943–45 | No team | | | | | | |
| Frank Camp (Kentucky Intercollegiate Athletic Conference)(1946–1947) |
| 1946 | Louisville | 6–2 | 2–2 | 4th | | | |
| 1947 | Louisville | 7–0–1 | 2–0 | T–1st | | | |
| Frank Camp(Ohio Valley Conference)(1948) |
| 1948 | Louisville | 5–5 | 1–1 | T–3rd | | | |
| Frank Camp(Independent)(1949–1962) |
| 1949 | Louisville | 8–3 | | | | | |
| 1950 | Louisville | 3–6–1 | | | | | |
| 1951 | Louisville | 5–4 | | | | | |
| 1952 | Louisville | 3–5 | | | | | |
| 1953 | Louisville | 1–7 | | | | | |
| 1954 | Louisville | 3–6 | | | | | |
| 1955 | Louisville | 7–2 | | | | | |
| 1956 | Louisville | 6–3 | | | | | |
| 1957 | Louisville | 9–1 | | | W Sun | | |
| 1958 | Louisville | 4–4 | | | | | |
| 1959 | Louisville | 6–4 | | | | | |
| 1960 | Louisville | 7–2 | | | | | |
| 1961 | Louisville | 6–3 | | | | | |
| 1962 | Louisville | 6–4 | | | | | |
| Frank Camp(Missouri Valley Conference)(1963–1968) |
| 1963 | Louisville | 3–7 | 1–3 | 5th | | | |
| 1964 | Louisville | 1–9 | 0–4 | 5th | | | |
| 1965 | Louisville | 6–4 | 3–1 | 2nd | | | |
| 1966 | Louisville | 6–4 | 1–3 | T–4th | | | |
| 1967 | Louisville | 5–5 | 1–3 | 4th | | | |
| 1968 | Louisville | 5–5 | 2–3 | T–4th | | | |
| Lee Corso (Missouri Valley Conference)(1969–1972) |
| 1969 | Louisville | 5–4–1 | 2–3 | T–3rd | | | |
| 1970 | Louisville | 8–3–1 | 4–0 | 1st | T Pasadena | | |
| 1971 | Louisville | 6–3–1 | 3–2 | T–2nd | | | |
| 1972 | Louisville | 9–1 | 4–1 | T–1st | | 16 | 18 |
| T. W. Alley (Missouri Valley Conference)(1973–1974) |
| 1973 | Louisville | 5–6 | 3–2 | T–3rd | | | |
| 1974 | Louisville | 3–7 | 3–2 | 2nd | | | |
| Vince Gibson (Independent)(1975–1979) |
| 1975 | Louisville | 2–9 | | | | | |
| 1976 | Louisville | 5–6 | | | | | |
| 1977 | Louisville | 7–4–1 | | | L Independence | | |
| 1978 | Louisville | 7–4 | | | | | |
| 1979 | Louisville | 4–6–1 | | | | | |
| Bob Weber (Independent)(1980–1984) |
| 1980 | Louisville | 5–6 | | | | | |
| 1981 | Louisville | 5–6 | | | | | |
| 1982 | Louisville | 5–6 | | | | | |
| 1983 | Louisville | 3–8 | | | | | |
| 1984 | Louisville | 2–9 | | | | | |
| Howard Schnellenberger (Independent)(1985–1994) |
| 1985 | Louisville | 2–9 | | | | | |
| 1986 | Louisville | 3–8 | | | | | |
| 1987 | Louisville | 3–7–1 | | | | | |
| 1988 | Louisville | 8–3 | | | | | |
| 1989 | Louisville | 6–5 | | | | | |
| 1990 | Louisville | 10–1–1 | | | W Fiesta | 12 | 14 |
| 1991 | Louisville | 2–9 | | | | | |
| 1992 | Louisville | 5–6 | | | | | |
| 1993 | Louisville | 9–3 | | | W Liberty | 23 | 24 |
| 1994 | Louisville | 6–5 | | | | | |
| Ron Cooper (Independent)(1995) |
| 1995 | Louisville | 7–4 | | | | | |
| Ron Cooper(Conference USA)(1996–1997) |
| 1996 | Louisville | 5–6 | 2–3 | T–3rd | | | |
| 1997 | Louisville | 1–10 | 0–6 | 7th | | | |
| John L. Smith (Conference USA)(1998–2002) |
| 1998 | Louisville | 7–5 | 4–2 | 3rd | L Motor City | | |
| 1999 | Louisville | 7–5 | 4–2 | T–2nd | L Humanitarian | | |
| 2000 | Louisville | 9–3 | 6–1 | 1st | L Liberty | | |
| 2001 | Louisville | 11–2 | 6–1 | 1st | W Liberty | 16 | 17 |
| 2002 | Louisville | 7–6 | 5–3 | 3rd | L GMAC | | |
| Bobby Petrino (Conference USA)(2003–2004) |
| 2003 | Louisville | 9–4 | 5–3 | T–3rd | L GMAC | | |
| 2004 | Louisville | 11–1 | 8–0 | 1st | W Liberty | 7 | 6 |
| Bobby Petrino(Big East Conference)(2005–2006) |
| 2005 | Louisville | 9–3 | 5–2 | 2nd | L Gator | 20 | 19 |
| 2006 | Louisville | 12–1 | 6–1 | 1st | W Orange † | 7 | 6 |
| Steve Kragthorpe (Big East Conference)(2007–2009) |
| 2007 | Louisville | 6–6 | 3–4 | T–5th | | | |
| 2008 | Louisville | 5–7 | 1–6 | 8th | | | |
| 2009 | Louisville | 4–8 | 1–6 | 7th | | | |
| Charlie Strong (Big East Conference)(2010–2012) |
| 2010 | Louisville | 7–6 | 3–4 | T–5th | W Beef 'O' Brady's | | |
| 2011 | Louisville | 7–6 | 5–2 | T–1st | L Belk | | |
| 2012 | Louisville | 11–2 | 5–2 | T–1st | W Sugar † | 13 | 13 |
| Charlie Strong(American Athletic Conference)(2013) |
| 2013 | Louisville | 12–1 | 7–1 | 2nd | W Russell Athletic | 15 | 15 |
| Bobby Petrino(Atlantic Coast Conference)(2014–2018) |
| 2014 | Louisville | 9–4 | 5–3 | 3rd (Atlantic) | L Belk | 24 | 24 |
| 2015 | Louisville | 8–5 | 5–3 | 3rd (Atlantic) | W Music City | | |
| 2016 | Louisville | 9–4 | 7–1 | T–1st (Atlantic) | L Citrus | 20 | 21 |
| 2017 | Louisville | 8–5 | 4–4 | T–3rd (Atlantic) | L TaxSlayer | | |
| 2018 | Louisville [n 1] | 2–10 [n 1] | 0–8 [n 1] | 7th (Atlantic) | | | |
| Scott Satterfield (Atlantic Coast Conference)(2019–2022) |
| 2019 | Louisville | 8–5 | 5–3 | 2nd (Atlantic) | W Music City | | |
| 2020 | Louisville | 4–7 | 3–7 | 12th | | | |
| 2021 | Louisville | 6–7 | 4–4 | T–4th (Atlantic) | L First Responder | | |
| 2022 | Louisville [n 2] | 8–5 [n 2] | 4–4 | T–3rd (Atlantic) | W Fenway | | |
| Jeff Brohm (Atlantic Coast Conference)(2023–present) |
| 2023 | Louisville | 10–4 | 7–1 | 2nd | L Holiday | 18 | 19 |
| 2024 | Louisville | 9–4 | 5–3 | T–4th | W Sun | | |
| 2025 | Louisville | 5–1 | 2–1 | | | | |
| Total: | 564–502–17 (.529) | |
| National championship Conference title Conference division title or championship game berth |
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