Date Time Opponent Site TV Result Attendance Source August 31 6:30 pm at Kentucky * ESPN2 W 40–2470,467 September 13 1:30 pm at Syracuse * WDRB W 30–2038,550 September 20 3:00 pm UTEP * W 42–1440,205 September 27 3:00 pm Temple * Papa John's Cardinal Stadium Louisville, KY W 21–1238,489 October 4 7:00 pm at South Florida ESPN Plus L 28–31 2OT 36,044 October 11 3:00 pm Army Papa John's Cardinal Stadium Louisville, KY W 34–1040,432 October 17 8:00 pm Tulane Papa John's Cardinal Stadium Louisville, KY ESPN W 47–2838,119 October 25 2:00 pm at East Carolina WDRB W 36–2033,420 [ 1] November 5 7:30 pm at No. 13 TCU ESPN2 L 28–3133,681 November 15 3:00 pm Memphis Papa John's Cardinal Stadium Louisville, KY (rivalry ) L 7–3730,114 November 22 3:15 pm Houston Papa John's Cardinal Stadium Louisville, KY W 66–4533,268 November 28 11:00 am at Cincinnati ESPN2 W 43–4011,993 December 18 7:30 pm vs. No. 14 Miami (OH) * ESPN2 L 28–4940,620 *Non-conference game Rankings from AP Poll released prior to the game All times are in Eastern time