| Rd | Date and local time | Opponent | Scores(St Kilda's scores indicated in bold) | Venue | Attendance | Ladder |
| Home | Away | Result |
|---|
| 1 | Saturday, 22 March (7:40 pm) | Melbourne | 10.8 (68) | 6.15 (51) | Won by 17 points | Etihad Stadium (H) | 31,657 | 8th |
| 2 | Saturday, 29 March (1:40 pm) | Greater Western Sydney | 15.5 (95) | 13.10 (88) | Won by 7 points | Etihad Stadium (H) | 19,640 | 6th |
| 3 | Saturday, 5 April (4:40 pm) | West Coast | 12.11 (83) | 8.10 (58) | Lost by 25 points | Patersons Stadium (A) | 36,448 | 9th |
| 4 | Sunday, 13 April (3:20 pm) | Adelaide | 7.8 (50) | 20.16 (136) | Lost by 86 points | Etihad Stadium (H) | 22,923 | 12th |
| 5 | Saturday, 19 April (7:40 pm) | Essendon | 9.11 (65) | 11.15 (81) | Lost by 16 points | Etihad Stadium (A) | 36,041 | 9th |
| 6 | Friday, 25 April (7:45 pm) | Brisbane Lions | 11.13 (79) | 12.10 (82) | Lost by 3 points | Westpac Stadium (H) | 13,409 | 11th |
| 7 | Saturday, 3 May (1:45 pm) | Hawthorn | 27.13 (175) | 4.6 (30) | Lost by 145 points | MCG (A) | 32,924 | 12th |
| 8 | Monday, 12 May (7:20 pm) | Carlton | 9.15 (69) | 15.11 (101) | Lost by 32 points | Etihad Stadium (H) | 26,708 | 14th |
| 9 | Sunday, 18 May (4:40 pm) | Gold Coast | 13.9 (87) | 19.11 (125) | Lost by 38 points | Etihad Stadium (H) | 14,625 | 15th |
| 10 | Bye | 16th |
| 11 | Friday, 30 May (7:50 pm) | Collingwood | 8.6 (54) | 21.14 (140) | Lost by 86 points | Etihad Stadium (H) | 34,855 | 16th |
| 12 | Saturday, 7 June (4:10 pm) | Port Adelaide | 19.15 (129) | 9.5 (59) | Lost by 70 points | Adelaide Oval (A) | 42,374 | 17th |
| 13 | Sunday, 15 June (1:10 pm) | Geelong | 20.13 (133) | 5.7 (37) | Lost by 96 points | Simonds Stadium (A) | 25,180 | 18th |
| 14 | Sunday, 22 June (3:20 pm) | West Coast | 10.10 (70) | 15.13 (103) | Lost by 33 points | Etihad Stadium (H) | 17,317 | 18th |
| 15 | Saturday, 28 June (2:10 pm) | Richmond | 11.7 (73) | 18.9 (117) | Lost by 44 points | Etihad Stadium (H) | 28,487 | 18th |
| 16 | Sunday, 6 July (1:10 pm) | Carlton | 24.7 (151) | 10.6 (66) | Lost by 85 points | Etihad Stadium (A) | 29,297 | 18th |
| 17 | Saturday, 12 July (2:10 pm) | North Melbourne | 13.14 (92) | 3.15 (33) | Lost by 59 points | Blundstone Arena (A) | 10,641 | 18th |
| 18 | Saturday, 19 July (4:40 pm) | Fremantle | 17.16 (118) | 9.6 (60) | Won by 58 points | Etihad Stadium (H) | 16,594 | 18th |
| 19 | Saturday, 2 August (7:40 pm) | Gold Coast | 17.15 (117) | 9.10 (64) | Lost by 53 points | Metricon Stadium (A) | 12,027 | 18th |
| 20 | Sunday, 10 August (3:20 pm) | Western Bulldogs | 15.9 (99) | 18.14 (122) | Lost by 23 points | Etihad Stadium (H) | 30,095 | 18th |
| 21 | Saturday, 16 August (1:45 pm) | Sydney | 19.13 (127) | 8.8 (56) | Lost by 71 points | SCG (A) | 31,361 | 18th |
| 22 | Sunday, 24 August (4:40 pm) | Richmond | 15.8 (98) | 10.12 (72) | Lost by 26 points | MCG (A) | 47,200 | 18th |
| 23 | Sunday, 31 August (2:50 pm) | Adelaide | 22.9 (141) | 9.8 (62) | Lost by 79 points | Adelaide Oval (A) | 44,969 | 18th |
