| Rd | Date and local time | Opponent | Scores(St Kilda's scores indicated in bold) | Venue | Attendance | Ladder |
| Home | Away | Result |
|---|
| 1 | Sunday, 27 March (2:50 pm) | Port Adelaide | 20.13 (133) | 15.10 (100) | Lost by 33 points | Adelaide Oval (A) | 42,896 | 13th |
| 2 | Saturday, 2 April (7:25 pm) | Western Bulldogs | 5.6 (36) | 13.15 (93) | Lost by 57 points | Etihad Stadium (A) | 37,7353 | 18th |
| 3 | Saturday, 9 April (1:45 pm) | Collingwood | 18.11 (119) | 14.6 (90) | Won by 29 points | MCG (H) | 50,903 | 13th |
| 4 | Saturday, 16 April (2:10 pm) | Hawthorn | 13.9 (87) | 13.6 (84) | Lost by 3 points | Aurora Stadium (A) | 36,650 | 12th |
| 5 | Sunday, 24 April (1:10 pm) | Greater Western Sydney | 12.7 (79) | 19.12 (126) | Lost by 47 points | Etihad Stadium (H) | 21,052 | 13th |
| 6 | Saturday, 30 April (1:45 pm) | Melbourne | 15.9 (96) | 20.15 (135) | Won by 39 points | Etihad Stadium (A) | 27,260 | 12th |
| 7 | Sunday, 8 May (3:20 pm) | North Melbourne | 11.9 (75) | 11.16 (82) | Lost by 7 points | Etihad Stadium (H) | 27,254 | 13th |
| 8 | Sunday, 15 May (2:40 pm) | West Coast | 20.12 (132) | 3.11 (29) | Lost by 103 points | Domain Stadium (A) | 36,140 | 14th |
| 9 | Sunday, 22 May (4:40 pm) | Essendon | 16.13 (109) | 9.9 (63) | Won by 46 points | Etihad Stadium (H) | 29,026 | 13th |
| 10 | Saturday, 28 May (4:35 pm) | Fremantle | 15.11 (101) | 10.7 (67) | Won by 34 points | Etihad Stadium (H) | 17,927 | 13th |
| 11 | Sunday, 5 June (4:10 pm) | Adelaide | 19.19 (133) | 6.9 (45) | Lost by 72 points | Adelaide Oval (A) | 40,896 | 13th |
| 12 | Sunday, 12 June (1:10 pm) | Carlton | 17.8 (110) | 12.6 (78) | Won by 32 points | Etihad Stadium (H) | 47,945 | 12th |
| 13 | Bye | 12th |
| 14 | Saturday, 25 June (7:25 pm) | Geelong | 14.9 (93) | 13.12 (90) | Won by 3 points | Etihad Stadium (H) | 28,745 | 12th |
| 15 | Saturday, 2 July (1:40 pm) | Gold Coast | 15.18 (108) | 8.20 (68) | Lost by 40 points | Metricon Stadium (A) | 14,071 | 13th |
| 16 | Sunday, 10 July (4:40 pm) | Essendon | 14.14 (98) | 17.7 (109) | Won by 11 points | Etihad Stadium (A) | 25,204 | 12th |
| 17 | Sunday, 17 July (3:20 pm) | Melbourne | 15.20 (110) | 11.8 (74) | Won by 36 points | Etihad Stadium (H) | 26,389 | 10th |
| 18 | Saturday, 23 July (7:25 pm) | Western Bulldogs | 9.6 (60) | 11.9 (75) | Won by 15 points | Etihad Stadium (A) | 26,532 | 9th |
| 19 | Saturday, 30 July (7:25 pm) | North Melbourne | 12.13 (85) | 8.14 (62) | Lost by 23 points | Etihad Stadium (A) | 44,287 | 10th |
| 20 | Sunday, 7 August (1:10 pm) | Carlton | 7.9 (51) | 19.8 (122) | Won by 71 points | MCG (A) | 37,797 | 9th |
| 21 | Saturday, 13 August (7:25 pm) | Sydney | 11.10 (76) | 23.8 (146) | Lost by 70 points | Etihad Stadium (H) | 33,059 | 10th |
| 22 | Saturday, 20 August (2:10 pm) | Richmond | 6.10 (46) | 7.13 (55) | Won by 9 points | MCG (A) | 35,255 | 9th |
| 23 | Sunday, 28 August (1:10 pm) | Brisbane Lions | 25.11 (161) | 15.13 (103) | Won by 58 points | Etihad Stadium (H) | 21,834 | 9th |