| Singles | |
|---|---|
| 2015 Hardee's Pro Classic | |
| Champion |  Louisa Chirico |
| Runner-up | Katerina Stewart |
| Score | 7–6(7–1), 3–6, 7–6(7–1) |
Grace Min was the defending champion, but lost to Alexandra Stevenson in the first round.
Fourth seed Louisa Chirico won the title, defeating wildcard Katerina Stewart in an all-American final, 7–6(7–1), 3–6, 7–6(7–1).
Grace Min (first round)
Michelle Larcher de Brito (quarterfinals) Sachia Vickery (first round) Louisa Chirico (champion)
Johanna Konta (second round)
Patricia Maria Țig (second round) Maria Sanchez (first round)
Katarzyna Piter (second round)| Semifinals | Final | ||||||||||||
 Paula Cristina Gonçalves | 4 | 0 | |||||||||||
| WC | Katerina Stewart | 6 | 6 | ||||||||||
| WC | Katerina Stewart | 61 | 6 | 61 | |||||||||
| 4 | Louisa Chirico | 77 | 3 | 77 | |||||||||
| 4 | Louisa Chirico | 63 | 6 | 6 | |||||||||
 Jovana Jakšić | 77 | 3 | 0 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | G Min | 1 | 66 | ||||||||||||||||||||||||
| WC | A Stevenson | 6 | 78 | WC | A Stevenson | 6 | 6 | ||||||||||||||||||||
| E Gallovits-Hall | 2 | 6 | 4 |  O Ianchuk | 1 | 3 | |||||||||||||||||||||
| O Ianchuk | 6 | 4 | 6 | WC | A Stevenson | 1 | 1 | ||||||||||||||||||||
| PC Gonçalves | 6 | 6 | PC Gonçalves | 6 | 6 | ||||||||||||||||||||||
 F Molinero | 4 | 1 | PC Gonçalves | 66 | 7 | 78 | |||||||||||||||||||||
 I Khromacheva | 7 | 2 | 4 | 8 | K Piter | 78 | 5 | 66 | |||||||||||||||||||
| 8 | K Piter | 5 | 6 | 6 | PC Gonçalves | 4 | 0 | ||||||||||||||||||||
| 3 | S Vickery | 4 | 64 | WC | K Stewart | 6 | 6 | ||||||||||||||||||||
| G Cé | 6 | 77 | G Cé | 4 | 6 | 0 | |||||||||||||||||||||
| S Crawford | 6 | 6 | S Crawford | 6 | 4 | 6 | |||||||||||||||||||||
 S Arvidsson | 2 | 4 | S Crawford | 6 | 5 | 1 | |||||||||||||||||||||
| LL |  K Kramperová | 1 | 1 | WC | K Stewart | 3 | 7 | 6 | |||||||||||||||||||
| WC | K Stewart | 6 | 6 | WC | K Stewart | 6 | 4 | 6 | |||||||||||||||||||
| J Boserup | 4 | 2 | 5 | J Konta | 1 | 6 | 3 | ||||||||||||||||||||
| 5 | J Konta | 6 | 6 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 7 | M Sanchez | 4 | 3 | ||||||||||||||||||||||||
| PR | J Pegula | 6 | 6 | PR | J Pegula | 7 | 6 | ||||||||||||||||||||
| WC |  M Drake | 3 | 6 | 2 |  C-y Hsu | 5 | 2 | ||||||||||||||||||||
| C-y Hsu | 6 | 3 | 6 | PR | J Pegula | 3 | 6 | 3 | |||||||||||||||||||
| B Pera | 77 | 6 | 4 | L Chirico | 6 | 3 | 6 | ||||||||||||||||||||
| Q | E Ianchuk | 65 | 3 | B Pera | 4 | 5 | |||||||||||||||||||||
| A Kiick | 3 | 64 | 4 | L Chirico | 6 | 7 | |||||||||||||||||||||
| 4 | L Chirico | 6 | 77 | 4 | L Chirico | 63 | 6 | 6 | |||||||||||||||||||
| 6 | PM Țig | 6 | 6 | J Jakšić | 77 | 3 | 0 | ||||||||||||||||||||
| Q | J Cako | 2 | 2 | 6 | PM Țig | 6 | 3 | 1 | |||||||||||||||||||
| C Whoriskey | 67 | 6 | 5 | J Jakšić | 3 | 6 | 6 | ||||||||||||||||||||
| J Jakšić | 79 | 2 | 7 | J Jakšić | 6 | 6 | |||||||||||||||||||||
| Q |  P Rampre | 2 | 0 | 2 | M Larcher de Brito | 3 | 1 | ||||||||||||||||||||
| Q |  J Moore | 6 | 6 | Q | J Moore | 2 | 0 | ||||||||||||||||||||
| WC | TA Black | 3 | 6 | 2 | 2 | M Larcher de Brito | 6 | 6 | |||||||||||||||||||
| 2 | M Larcher de Brito | 6 | 2 | 6 | |||||||||||||||||||||||
Grace Min was the defending champion, having won the event in 2011, but did not compete.
Maria Fernanda Alves and Jessica Moore were the defending champions, having won the event in 2012, but they lost in the quarterfinals to Jan Abaza and Louisa Chirico.
Lucie Šafářová was the defending champion, but decided not to participate this year.
Anna Tatishvili was the defending champion, but lost in the first round to Bernarda Pera.
Heather Watson was the defending champion but chose not to participate.
Anna Tatishvili and Heather Watson were the defending champions, but Watson chose not to participate. Tatishvili partnered with Louisa Chirico, but they withdrew before playing their first round.
Dominika Cibulková was the defending champion, but she chose not to defend her title.
Taylor Townsend was the defending champion, but she chose not to participate.
Taylor Townsend was the defending champion, but lost in the first round to wildcard Erica Oosterhout.
Klára Koukalová was the defending champion, but chose not to participate this year.
Anna Tatishvili was the defending champion, but she lost to Julia Boserup in the quarterfinals.
Tatjana Maria was the defending champion, but lost in the first round to Catherine Bellis.
Timea Bacsinszky was the defending champion, but chose to compete in Doha instead.
Karolína Plíšková was the defending champion, but lost in the semifinals to Lucie Šafářová.
Petra Kvitová was the two-time defending champion, but lost in the semifinals to Agnieszka Radwańska.
Irina-Camelia Begu was the defending champion, but lost in the second round to Jana Čepelová.
Agnieszka Radwańska defeated Johanna Konta in the final, 6–4, 6–2 to win the women's singles tennis title at the 2016 China Open.
Yanina Wickmayer was the defending champion, but chose not to participate this year.
This was the first edition of the tournament.
Iga Świątek defeated Donna Vekić in the final, 6–3, 3–6, 6–0 to win the women's singles tennis title at the 2022 San Diego Open. It was her eighth title of the 2022 season. By winning the title, Świątek became the first player since Serena Williams in 2013 to win more than 10,000 ranking points in a single season.