| Singles | |
|---|---|
| 2016 Amex-Istanbul Challenger | |
| Champion |  Malek Jaziri |
| Runner-up |  Dudi Sela |
| Final score | 1–6, 6–1, 6–0 |
Karen Khachanov was the defending champion but chose not to participate.
Malek Jaziri won the title after defeating Dudi Sela 1–6, 6–1, 6–0 in the final.
Malek Jaziri (champion) Dudi Sela (final)
Tobias Kamke (semifinals)
Marco Chiudinelli (semifinals)
Marius Copil (quarterfinals)
Adrián Menéndez-Maceiras (second round)
Aldin Šetkić (first round)
Nikola Milojević (first round)| Semifinals | Final | ||||||||||||
| 1 | Malek Jaziri | 6 | 6 | ||||||||||
| 3 | Tobias Kamke | 3 | 4 | ||||||||||
| 1 | Malek Jaziri | 1 | 6 | 6 | |||||||||
| 2 | Dudi Sela | 6 | 1 | 0 | |||||||||
| 4 | Marco Chiudinelli | 3 | 3 | ||||||||||
| 2 | Dudi Sela | 6 | 6 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | M Jaziri | 6 | 77 | ||||||||||||||||||||||||
 D Kuzmanov | 4 | 63 | 1 | M Jaziri | 3 | 6 | 6 | ||||||||||||||||||||
| WC |  Muhammet Haylaz | 6 | 4 | 6 | WC | M Haylaz | 6 | 3 | 2 | ||||||||||||||||||
 C Hemery | 4 | 6 | 1 | 1 | M Jaziri | 6 | 6 | ||||||||||||||||||||
| WC | A Çelikbilek | 7 | 6 | M Sieber | 4 | 0 | |||||||||||||||||||||
 F Horanský | 5 | 4 | WC | A Çelikbilek | 6 | 1 | 4 | ||||||||||||||||||||
| Marc Sieber | 5 | 77 | 6 | M Sieber | 4 | 6 | 6 | ||||||||||||||||||||
| 7 | A Šetkić | 7 | 63 | 2 | 1 | M Jaziri | 6 | 6 | |||||||||||||||||||
| 3 | T Kamke | 6 | 6 | 3 | T Kamke | 3 | 4 | ||||||||||||||||||||
 S Griekspoor | 4 | 3 | 3 | T Kamke | 6 | 6 | |||||||||||||||||||||
| Q |  DE Galán | 6 | 77 | Q | DE Galán | 3 | 2 | ||||||||||||||||||||
 V Manafov | 3 | 61 | 3 | T Kamke | 6 | 6 | |||||||||||||||||||||
| WC | A Yüksel | 6 | 77 | 5 | M Copil | 2 | 4 | ||||||||||||||||||||
| Q | José Francisco Vidal Azorín | 2 | 62 | WC | A Yüksel | 6 | 62 | 4 | |||||||||||||||||||
| Y Hanfmann | 63 | 6 | 1 | 5 | M Copil | 3 | 77 | 6 | |||||||||||||||||||
| 5 | M Copil | 77 | 4 | 6 | |||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 8 | N Milojević | 77 | 65 | 1 | |||||||||||||||||||||||
| M İlhan | 65 | 77 | 6 | M İlhan | 6 | 6 | |||||||||||||||||||||
 Y Mertens | 6 | 6 | Y Mertens | 3 | 4 | ||||||||||||||||||||||
| WC | Barkın Yalçinkale | 0 | 0 | M İlhan | 4 | 2 | |||||||||||||||||||||
 A Pavić | 6 | 6 | 4 | M Chiudinelli | 6 | 6 | |||||||||||||||||||||
| PR |  D Matsukevich | 1 | 2 | A Pavić | 1 | 2 | |||||||||||||||||||||
| Q | Vitaly Kozyukov | 5 | 0 | 4 | M Chiudinelli | 6 | 6 | ||||||||||||||||||||
| 4 | M Chiudinelli | 7 | 6 | 4 | M Chiudinelli | 3 | 3 | ||||||||||||||||||||
| 6 | A Menéndez-Maceiras | 77 | 6 | 2 | D Sela | 6 | 6 | ||||||||||||||||||||
| Marc Giner | 64 | 1 | 6 | A Menéndez-Maceiras | 6 | 1 | 4 | ||||||||||||||||||||
| Q | C İlkel | 3 | 5 |  M Konečný | 4 | 6 | 6 | ||||||||||||||||||||
| Michal Konečný | 6 | 7 | M Konečný | 1 | 5 | ||||||||||||||||||||||
 A Bega | 62 | 2 | 2 | D Sela | 6 | 7 | |||||||||||||||||||||
| S Doumbia | 77 | 6 | S Doumbia | 2 | 1 | ||||||||||||||||||||||
| T Griekspoor | 2 | 5 | 2 | D Sela | 6 | 6 | |||||||||||||||||||||
| 2 | D Sela | 6 | 7 | ||||||||||||||||||||||||
Benjamin Becker was the defending champion, however he chose to compete in Rome instead.
Dudi Sela defeated Rainer Schüttler in the final. He defeated him 7–6(3), 6–3.
Marcos Baghdatis was the defending champion, but chose to compete in ATP 500 in Washington instead.
Dudi Sela won the title, defeating Ričardas Berankis 7–5, 6–2 in the finals.
Malek Jaziri is a professional Tunisian tennis player. He reached the final of Istanbul in 2018, the semifinals of Moscow in 2012, Winston-Salem in 2015, Dubai in 2018 and the quarterfinals of Dubai in 2014.
Lim Yong-kyu was the defending champion, but lost to Greg Jones in the 2nd round.
Dudi Sela defeated Tatsuma Ito 6–2, 6–7(5), 6–3 in the final match.
Dudi Sela was the defending champion, but he lost in the quarterfinals to Grega Žemlja.
Grega Žemlja won the title defeating Karol Beck in the final 7–6(7–3), 4–6, 6–4.
Denis Istomin was the defending champion but decided not to participate.
Uladzimir Ignatik won the final 6–3, 7–6(7–3) against Lukáš Lacko.
Malek Jaziri was the defending champion but was defeated in the second round by Henri Laaksonen.
Marc Gicquel won the title, defeating Matthias Bachinger 3–6, 6–3, 6–4 in the final.
Uladzimir Ignatik was the defending champion, but lost to Radu Albot in the first round.
Dudi Sela won the title defeating Teymuraz Gabashvili in the final 6–1, 6–2.
Mikhail Youzhny was the defending champion but lost to Thomaz Bellucci in the first round.
This is the first edition of the tournament.
Ivo Karlović was the defending champion from when the tournament was last held in 2008, but chose not to participate.
Steve Darcis was the defending champion, but lost in the second round. Malek Jaziri won the title defeating Igor Sijsling in the final 5–7, 7–5, 6–4
Ruben Bemelmans was the defending champion, but decided not to defend his title.
Rajeev Ram was the defending champion, but lost in the second round to Dudi Sela.
Saketh Myneni was the defending champion but lost in the second round to Taro Daniel.
Frédéric Niemeyer was the defending champion, but lost in second round to Peter Polansky.
This was the first edition of the tournament at the Challenger level.
Andy Murray was the defending champion but withdrew with a hip injury before the tournament began.
Dudi Sela was the defending champion but lost in the first round to Hugo Grenier.
Enzo Couacaud was the defending champion but chose not to defend his title.