| Singles | |
|---|---|
| 2016 Istanbul Open | |
| Champion |  Diego Schwartzman |
| Runner-up |  Grigor Dimitrov |
| Final score | 6–7(5–7), 7–6(7–4), 6–0 |
Roger Federer was the defending champion, but chose not to participate this year.
Diego Schwartzman won the title, defeating Grigor Dimitrov in the final, 6–7(5–7), 7–6(7–4), 6–0.
The top four seeds receive a bye into the second round.
Bernard Tomic (second round) Grigor Dimitrov (final)
Ivo Karlović (semifinals) Federico Delbonis (semifinals)
Marcel Granollers (quarterfinals)
Jiří Veselý (quarterfinals)
Teymuraz Gabashvili (first round) Albert Ramos Viñolas (quarterfinals)| Semifinals | Final | ||||||||||||
| Diego Schwartzman | 65 | 6 | 6 | ||||||||||
| 4 | Federico Delbonis | 77 | 3 | 2 | |||||||||
| Diego Schwartzman | 65 | 77 | 6 | ||||||||||
| 2 | Grigor Dimitrov | 77 | 64 | 0 | |||||||||
| 3 | Ivo Karlović | 60 | 62 | ||||||||||
| 2 | Grigor Dimitrov | 77 | 77 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | B Tomic | 2 | 2 | ||||||||||||||||||||||||
| F Bagnis | 1 | 4 | D Schwartzman | 6 | 6 | ||||||||||||||||||||||
| D Schwartzman | 6 | 6 | D Schwartzman | 5 | 77 | 6 | |||||||||||||||||||||
 I Marchenko | 6 | 3 | 6 |  D Džumhur | 7 | 64 | 2 | ||||||||||||||||||||
| LL | M González | 3 | 6 | 1 | I Marchenko | 3 | 7 | 3 | |||||||||||||||||||
| D Džumhur | 6 | 6 | D Džumhur | 6 | 5 | 6 | |||||||||||||||||||||
| 7 | T Gabashvili | 4 | 2 | D Schwartzman | 65 | 6 | 6 | ||||||||||||||||||||
| 4 | F Delbonis | 77 | 3 | 2 | |||||||||||||||||||||||
| 4 | F Delbonis | 6 | 2 | 6 | |||||||||||||||||||||||
 D Sela | 6 | 6 | D Sela | 3 | 6 | 4 | |||||||||||||||||||||
| Q | A Rublev | 3 | 2 | 4 | F Delbonis | 78 | 6 | ||||||||||||||||||||
| WC | K Khachanov | 6 | 64 | 6 | 8 | A Ramos Viñolas | 66 | 4 | |||||||||||||||||||
 A Bedene | 4 | 77 | 4 | WC | K Khachanov | 6 | 1 | 0 | |||||||||||||||||||
 A Mannarino | 5 | 1 | 8 | A Ramos Viñolas | 4 | 6 | 6 | ||||||||||||||||||||
| 8 | A Ramos Viñolas | 7 | 6 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 5 | M Granollers | 6 | 711 | ||||||||||||||||||||||||
| WC |  C İlkel | 1 | 69 | 5 | M Granollers | 6 | 6 | ||||||||||||||||||||
| Q | C Berlocq | 2 | 3 |  H Chung | 3 | 4 | |||||||||||||||||||||
| H Chung | 6 | 6 | 5 | M Granollers | 62 | 77 | 4 | ||||||||||||||||||||
| Q | R Olivo | 5 | 4 | 3 | I Karlović | 77 | 65 | 6 | |||||||||||||||||||
 D Lajović | 7 | 6 | D Lajović | 611 | 67 | ||||||||||||||||||||||
| 3 | I Karlović | 713 | 79 | ||||||||||||||||||||||||
| 3 | I Karlović | 60 | 62 | ||||||||||||||||||||||||
| 6 | J Veselý | 6 | 7 | 2 | G Dimitrov | 77 | 77 | ||||||||||||||||||||
 T de Bakker | 3 | 5 | 6 | J Veselý | 65 | 6 | 6 | ||||||||||||||||||||
| R Carballés Baena | 6 | 6 | R Carballés Baena | 77 | 2 | 2 | |||||||||||||||||||||
| WC | M İlhan | 2 | 4 | 6 | J Veselý | 61 | 1 | ||||||||||||||||||||
| Q |  A Ungur | 6 | 6 | 2 | G Dimitrov | 77 | 6 | ||||||||||||||||||||
| F Krajinović | 3 | 3 | Q | A Ungur | 5 | 6 | 5 | ||||||||||||||||||||
| 2 | G Dimitrov | 7 | 4 | 7 | |||||||||||||||||||||||
Máximo González (qualifying competition, lucky loser) Carlos Berlocq (qualified) Andrey Rublev (qualified)
Radu Albot (first round) Renzo Olivo (qualified)
Alessandro Giannessi (qualifying competition) Marius Copil (qualifying competition) Adrian Ungur (qualified)| First round | Qualifying competition | ||||||||||||
| 1 | Máximo González | 63 | 6 | 6 | |||||||||
| Alt | Tomislav Brkić | 77 | 3 | 4 | |||||||||
| 1 | Máximo González | 3 | 5 | ||||||||||
| 8 | Adrian Ungur | 6 | 7 | ||||||||||
 Hiroki Moriya | 1 | 6 | 2 | ||||||||||
| 8 | Adrian Ungur | 6 | 1 | 6 | |||||||||
| First round | Qualifying competition | ||||||||||||
| 2 | Carlos Berlocq | 6 | 65 | 7 | |||||||||
| WC | Dimitar Kuzmanov | 4 | 77 | 5 | |||||||||
| 2 | Carlos Berlocq | 77 | 6 | ||||||||||
| 6 | Alessandro Giannessi | 63 | 3 | ||||||||||
 Michael Linzer | 0r | ||||||||||||
| 6 | Alessandro Giannessi | 1 | |||||||||||
| First round | Qualifying competition | ||||||||||||
| 3 | Andrey Rublev | 6 | 6 | ||||||||||
| WC | Sarp Ağabigün | 3 | 3 | ||||||||||
| 3 | Andrey Rublev | 4 | 6 | 6 | |||||||||
| 7 | Marius Copil | 6 | 0 | 3 | |||||||||
| Flavio Cipolla | 2 | 4 | |||||||||||
| 7 | Marius Copil | 6 | 6 | ||||||||||
| First round | Qualifying competition | ||||||||||||
| 4 | Radu Albot | 65 | 2 | ||||||||||
| Ivan Nedelko | 77 | 6 | |||||||||||
| Ivan Nedelko | 4 | 3 | |||||||||||
| 5 | Renzo Olivo | 6 | 6 | ||||||||||
| Michal Konečný | 4 | 64 | |||||||||||
| 5 | Renzo Olivo | 6 | 77 | ||||||||||
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